Original title: IL 57 - Sporadic colorectal cancer: From genetic make-up to complex phenotypic measurement, from risk determination to prognostic markers
Authors: Vodička, Pavel ; Slyšková, Jana ; Pardini, B. ; Naccarati, A. ; Souček, P. ; Vodičková, Ludmila ; Vymetálková, Veronika ; Svoboda, Miroslav ; Foersti, A. ; Hemminki, K.
Document type: Papers
Conference/Event: Annual Meeting European Environmental Mutagenesis and Genomics Society /44./, Prague (CZ), 20150823
Year: 2015
Language: eng
Abstract: Colorectal carcinogenesis (CRC), is a complex process, resulting in both genomic and chromosomal instabilities. The valid theories of carcinogenesis accent either the role of somatic mutation or the surrounding microenvironment, however neither of them explains all features of cancer. Uncontrolled proliferation and genomic instability point to the DNA damage response and repair as to the key players. In the present study, we will overview several biomarkers in mapping heterogeneous complex CRC disease and providing prognostic information.\nVariants in genes involved in important pathways, such as DNA repair, cell cycle control, folate metabolism and methylation, insulin resistance and obesity, ABC transporters, selenoprotein genes, genes involved in inflammatory/immune response have shown various degree of association with CRC risk. We present also the data on mutations in high risk genes involved in colorectal carcinogenesis. Gene expression levels were determined in relevant pathways and complemented with other important parameters (epigenetic regulators of transcription by methylation). Additionally, the role of post-transcriptional regulation via miRNA or lncRNA was investigated in relation to the risk of CRC and the efficacy of chemotherapy. We have discovered several genetic and epigenetic markers affecting independently the prognosis of CRC. Functional DNA repair tests (complex phenotype) have been implemented as markers of individual susceptibility to sporadic CRC and its prognosis.\nAn application of the whole set of various biomarkers is inevitable to define the phenotypic landscape of the disease and to delineate the individual response to the therapy.\n
Keywords: cancer risk determination; colorectal cancer; prognostic markers
Project no.: NT14329 (CEP), NT14056 (CEP), LH13061 (CEP), GAP304/12/1585 (CEP), NT13424 (CEP)
Funding provider: GA MZd, GA MZd, GA MŠk, GA ČR, GA MZd
Host item entry: 44th Annual Meeting EEMGS 2015. Final Programme and Abstract Book

Institution: Institute of Experimental Medicine AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0272305

Permalink: http://www.nusl.cz/ntk/nusl-361673

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Research > Institutes ASCR > Institute of Experimental Medicine
Conference materials > Papers
 Record created 2017-08-18, last modified 2019-10-20

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