Název:
Phenotypic Analyses of the HD transgenic Minipig Model
Autoři:
Motlík, Jan ; Ellederová, Zdeňka Typ dokumentu: Výzkumné zprávy
Rok:
2016
Jazyk:
eng
Abstrakt: The transgenic model of Huntington’s disease in minipig (TgHD) was created in 2009 and information coding the sequence of N-terminal part of human mutated huntingtin was transferred to subsequent generations from both female and male sides. In each litter, transgenic (TgHD) and wild-type (WT) piglets were born in approximately equal ratio. At present, the Laboratory of Cell Regeneration and Plasticity keeps sets of animals in F2 and F3 generations with identical genetic background and bred in identical conditions of feeding and housing. The present research project was focused on a complex of non-invasive and invasive approaches to WT and TgHD minipigs to achieve the entire phenotypic analysis of HD progression in this large animal model.
Klíčová slova:
minipig Číslo projektu: A-8248 Poskytovatel projektu: CHDI Foundation
Instituce: Ústav živočišné fyziologie a genetiky AV ČR
(web)
Informace o dostupnosti dokumentu:
Dokument je dostupný v příslušném ústavu Akademie věd ČR. Původní záznam: http://hdl.handle.net/11104/0269505