Název: Screening of the health risks of biofilms using a battery of in vitro toxicity assays
Autoři: Bláha, Luděk ; Babica, P. ; Sabatier, S. ; Admiraal, W. ; Maršálek, Blahoslav
Typ dokumentu: Příspěvky z konference
Konference/Akce: Regional Meeting of the Central and Eastern European Section /7./, Brno (CZ), 2002-10-14 / 2002-10-16
Rok: 2002
Jazyk: eng
Abstrakt: Traces of microcystin-lika compounds were detected by HPCL in biofilm samples from Netherlands. Half of the tested samples had no significant effect in any of the in vitro assays, other biofilms elicicted weak inhibitory/toxic effects mostly in high concentrations, which are not environmentally relevant. Most of observed weak effect seem to be associated with oxidative stress, an important toxicologicalĺmechanisms, as detected by depletion of intracellular antioxidantĺGHS by several biofilm samples. Potential adverse effects ofĺexterne polutants, which are known to accumulate in theĺperyphyton biomass should not underestimated. Mutagenicity andĺneurotoxicity of biofilm metabolits seems to be negligible. Weekĺadverse effects of biofilm extracts detected in a batery of inĺvitro assays indicate relatively low human health risksĺassociated with biofilm toxicity.
Klíčová slova: HCPL; microcystin
Číslo projektu: CEZ:AV0Z6005908 (CEP), KSK6005114 (CEP), EVKI-CT-1999-00001
Poskytovatel projektu: GA AV ČR, BIOFILMS
Zdrojový dokument: SECOTOX 2002: Trends and advances in environmental chemistry and ecotoxicology, ISBN 80-210-2971-4

Instituce: Botanický ústav AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný v příslušném ústavu Akademie věd ČR.
Původní záznam: http://hdl.handle.net/11104/0027734

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-21746


Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Botanický ústav
Konferenční materiály > Příspěvky z konference