Original title: Electrochemical Methods for Determination of Three Tumor Biomarkers for Neuroblastoma: Homovanillic Acid, Vanillylmandelic Acid, and 5-Hydroxyindoleacetic Acid
Authors: Makrlíková, A. ; Ktena, A. ; Fischer, J. ; Navrátil, Tomáš ; Vyskočil, V.
Document type: Papers
Conference/Event: Moderní elektrochemické metody /36./, Jetřichovice (CZ), 20160523
Year: 2016
Language: eng
Abstract: Tumor biomarkers – homovanillic acid, vanillylmandelic acid, and 5-hydroxyindoleacetic acid – have been determined at a screen-printed carbon electrode in small volume samples. For all measurements, Britton-Robinson buffer (0.04 moll−1, pH 3.0) was used as an optimum medium for all three analytes. Dependences of the peak current on the concentration were linear for all compounds, with the limits of quantification 0.8 μmol∙l–1 for homovanillic acid, 0.2 μmol∙l–1 for vanillylmandelic acid, and 0.2 μmol∙l–1 for 5-hydroxyindoleacetic acid. Depending on the results of the measurements, the future experiments should be performed in human urine.
Keywords: Differential pulse voltammetry; Homovanillic acid; Screen-printed carbon electrodes
Host item entry: XXXVI. Moderní elektrochemické metody. Sborník přednášek, ISBN 978-80-905221-4-5

Institution: J. Heyrovsky Institute of Physical Chemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0259897

Permalink: http://www.nusl.cz/ntk/nusl-204436


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Research > Institutes ASCR > J. Heyrovsky Institute of Physical Chemistry
Conference materials > Papers