Home > Conference materials > Papers > Electrochemical Methods for Determination of Three Tumor Biomarkers for Neuroblastoma: Homovanillic Acid, Vanillylmandelic Acid, and 5-Hydroxyindoleacetic Acid
Original title:
Electrochemical Methods for Determination of Three Tumor Biomarkers for Neuroblastoma: Homovanillic Acid, Vanillylmandelic Acid, and 5-Hydroxyindoleacetic Acid
Authors:
Makrlíková, A. ; Ktena, A. ; Fischer, J. ; Navrátil, Tomáš ; Vyskočil, V. Document type: Papers Conference/Event: Moderní elektrochemické metody /36./, Jetřichovice (CZ), 20160523
Year:
2016
Language:
eng Abstract:
Tumor biomarkers – homovanillic acid, vanillylmandelic acid, and 5-hydroxyindoleacetic acid – have been determined at a screen-printed carbon electrode in small volume samples. For all measurements, Britton-Robinson buffer (0.04 moll−1, pH 3.0) was used as an optimum medium for all three analytes. Dependences of the peak current on the concentration were linear for all compounds, with the limits of quantification 0.8 μmol∙l–1 for homovanillic acid, 0.2 μmol∙l–1 for vanillylmandelic acid, and 0.2 μmol∙l–1 for 5-hydroxyindoleacetic acid. Depending on the results of the measurements, the future experiments should be performed in human urine.
Keywords:
Differential pulse voltammetry; Homovanillic acid; Screen-printed carbon electrodes Host item entry: XXXVI. Moderní elektrochemické metody. Sborník přednášek, ISBN 978-80-905221-4-5
Institution: J. Heyrovsky Institute of Physical Chemistry AS ČR
(web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0259897