Název:
Determination of enantiopurity of new types of acyclic nucleoside phosphonates by capillary electrophoresis with cyclodextrins-based chiral selectors
Autoři:
Šolínová, Veronika ; Kaiser, Martin Maxmilian ; Lukáč, Miloš ; Janeba, Zlatko ; Kašička, Václav Typ dokumentu: Příspěvky z konference Konference/Akce: Advances in Chromatography and Electrophoresis & Chiranal 2014, Olomouc (CZ), 2014-02-10 / 2014-02-14
Rok:
2014
Jazyk:
eng
Abstrakt: Capillary electrophoresis with neutral and cationic cyclodextrins as chiral selectors was applied for determination of enantiopurity analysis of new types of six acyclic nucleoside phosphonates, nucleotide analogues bearing ((3-hydroxypropan-2-yl)-1H-1,2,3-triazol-4-yl)phosphonic acid, 2-((diisopropoxyphosphonyl)methoxy)propanoic acid or 2 (phosphonomethoxy)propanoic acid moieties attached to adenine, guanine, 2,6-diaminopurine, uracil and 5-bromouracil nucleobases. All these compounds were found to be synthesized in pure enantiomeric forms. Employing the UV-absorption detection at 206 nm, their detection limits were in the low micromolar level.
Klíčová slova:
acyclic nucleoside phosphonates; capillary electrophoresis; enantiopurity analysis Číslo projektu: GAP206/12/0453 (CEP), GA13-17224S (CEP), VG20102015046 (CEP) Poskytovatel projektu: GA ČR, GA ČR, GA MV Zdrojový dokument: Acta Universitatis Palackianae Olomucensis. Facultas Rerum Naturalium. Chemica 51S, ISBN 978-80-244-3950-1, ISSN 0232-0061
Instituce: Ústav organické chemie a biochemie AV ČR
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Informace o dostupnosti dokumentu:
Dokument je dostupný v příslušném ústavu Akademie věd ČR. Původní záznam: http://hdl.handle.net/11104/0235088