Original title: Novel conformationally locked nucleosides and nucleotides
Authors: Nencka, Radim ; Šála, Michal ; Hřebabecký, Hubert ; Procházková, Eliška ; Mackman, R. ; Barauskas, O. ; Lee, Y. J. ; Tian, Y.
Document type: Papers
Conference/Event: Symposium on Chemistry of Nucleic Acid Components /16./, Český Krumlov (CZ), 2014-06-08 / 2014-06-13
Year: 2014
Language: eng
Abstract: We report on a synthesis of two novel types of conformationally locked nucleoside analogues. We prepared 7 membered ring 3’,5’-bridged nucleoside analogs locked in a Southern conformation. These nucleoside analogues were converted in one pot to appropriate phosphoramidate prodrugs using boronate methodology. We also devised and prepared a novel carbocyclic nucleoside by replacing furanose with cyclohexene that resulted in a locked Northern conformation similar to LNA monomers. Further details on the biological activity and application for oligonucleotide synthesis will be discussed in detail.
Keywords: locked nucleoside analogues; oligonucleotide synthesis
Project no.: GPP207/12/P625 (CEP), VG20102015046 (CEP)
Funding provider: GA ČR, GA MV
Host item entry: Chemistry of Nucleic Acid Components. 16th Symposium, ISBN 978-80-86241-50-0

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0234281

Permalink: http://www.nusl.cz/ntk/nusl-174425


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers