National Repository of Grey Literature 339 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
Metabolism of immunosuppressants in children with inflammatory bowel disease
Pospíšilová, Kristýna ; Bronský, Jiří (advisor) ; Leníček, Martin (referee) ; Dědek, Petr (referee)
Metabolism of immunosuppressants in children with inflammatory bowel disease Abstract Thiopurines are still used as the main immunosuppressants in the maintenance therapy of paediatric Crohn's disease. According to official guidelines, in case of failure, biological therapy (mainly infliximab or adalimumab) is generally commenced. The present thesis focuses on the possibilities of therapy optimization in children in whom the conventional Crohn's disease therapy has failed based on the metabolism of administered immunosuppressive medications. We confirmed that the knowledge of thiopurine metabolites concentration in red blood cells may help to monitor patients' adherence to therapy. However, according to our observations in children on combination therapy of infliximab and thiopurine lower concentrations of 6- thioguanine (the active metabolite of thiopurines) seems to be effective compared to what has been expected. We presented a web application designed to partially substitute for the thiopurine metabolite measurements based on easily available laboratory data. Last, but not least, we confirmed that the clinical effect and safety profile of both adalimumab and infliximab are similar in the treatment of paediatric Crohn's disease. Only in case of family history of atopic dermatitis adalimumab may be preferred.
Clinical and elektrophysiology longitudinal study of children with hereditary neurophathy Charlot-Marie-Tooth type 1A
Haberlová, Jana ; Seeman, Pavel (advisor) ; Syka, Josef (referee) ; Ambler, Zdeněk (referee) ; Vondráček, Petr (referee)
Hereditary peripheral neuropathy, known asCharcot Marie Tooth disease (CMT) and with an incidence of 1:2500 -1:10 000, is the most common hereditary neuromuscular disorder. Type CMT 1A is the most common form of CMT refering to the group of primary demyelinitateing motor and sensory peripheral neuropathies. CMT phenotype is clinically characterized by chronic slowly progressive distal muscle weakness and atrophy with hypo or areflexia and mild to moderate acral sensory loss. The lower limbs are predominantly affected. The aims of this study were to describe the first and most common signs of CMT1A during the first decade of life, to characterize their progression, and evaluate the sensitivity of CMTNS (Charcot-Marie- Tooth neuropath scale) for CMT1A young children. Sixteen children aged 3 to 10 years with genetically proven CMT 1A were examined. All patients were clinically examined, underwent electrophysiological examination, and were scored by CMTNS. Eight were followed for up to two years. Our data shows that CMT 1A in children under the age of 10 years causes only a mild disability. Initial signs of CMT 1A were difficulty in heel walking (15/16, 93%) and lower limb hypo or areflexia ( 13/16, 81%). The test of heel walking can be easily used as a screening test for hereditary neuropathies in pediatrics....
PEDI - Pediatric Evaluation of Disability Inventory: Practical Application in Occupational Therapy
Krulová, Anna ; Haškovcová, Eliška (advisor) ; Nováková, Olga (referee)
Author: Anna Krulová Supervisor: Mgr. Eliška Haškovcová Title: PEDI - Pediatric Evaluation of Disability Inventory: Practical Application in Occupational Therapy The Pediatric Evaluation of Disability Inventory (PEDI) is a standardized assessment developed in the USA. The PEDI samples key functional skills, caregiver assistance and modification in three content domains: self-care, mobility and social function. This thesis is aimed at the characterization of the PEDI and its practical application in occupational therapy. The theoretical part contains introduction of the PEDI, description of cooperation between occupational therapist and parents and brief description of functional skills development to the age of 7. Occupational therapists and parents information value of the PEDI is described in the practical part. The advantages and disadvantages for occupational therapist are also summarized. 20 assessments were used to achieve the aims of this theses. Feedback from the respondents was recieved using the anonymous online questionnaire. The detailed case study and graphs demonstrate the results of the research. Key words:  Pediatric Evaluation of Disability Inventory (PEDI)  occupational therapy  pediatrics  functional skills  assessment  disability  parents
The EACH Charter as an instrument of bolstering and protection of ethical aspects of paediatric hospitalization
Královec, Jiří ; Fošum, Jan (advisor) ; Svoboda, David (referee)
The Charter of rights of children in hospital (the EACH Charter) is an international document authored by the European Association for Children in Hospital (EACH) in the eighties of the twentieth century. The Charter can be perceived as a response to the fact that a child's stay in hospital - and paediatric hospital as an institution - is strongly influenced and formed by economical, technological and administrative aspects prevailing over the ethical ones. The Charter highlights specific situations where the health care profession - by neglecting children's needs and ignoring and/or tolerating avoidable suffering - becomes unethical. The aim of my thesis is to scrutinize the ethical appeal of the EACH Charter and to explore the Charter's ethical implications for contemporary paediatric practice in the Czech Republic.
Design of Digital Baby Scale
Trněná, Eliška ; Sládek, Josef (referee) ; Rubínová, Dana (advisor)
The topic of this bachelor thesis is the design of baby scales for medical facilities. The aim is a design with an unique shape that meets the technical, ergonomic and safety requirements associated with weighing children. The work is based on the analysis of the current state of knowledge, the shape fits into the environment of pediatrics. The design guarantees safety for infants, the possibility of comfortable handling of the device and emphasizes aesthetics and visual friendliness.
The selected acute conditions in pediatrics from the point of view of paramedic
The bachelor thesis deals with the problems of states which can immediately endanger the child's life and are solved in pre-hospital emergency care by emergency squads including paramedics. They must possess the appropriate knowledge and experience. Without their early and effective help, a child patient could experience irreversible health changes or even die. The thesis is divided into theoretical and research part. The theoretical part deals with the differences between pediatric and adult patients because by providing pre-hospital emergency care it is important to think constantly about the fact that a child is not a small adult and that taking care of him or her carries its specifics which must be respected. Furthermore, this part deals with selected acute conditions in paediatrics from the point of view of a paramedic. The research part comprises of a quantitative research based on interviews containing 24 questions and the research group consisted of 12 paramedics performing their profession in the South Bohemian region. It includes analysis of acquired data and their evaluation. The goal of the work is to map the awareness of paramedics about the issue of selected acute states in paediatrics.
The current status of pediatrics nurse field and its impacts on practice
TUŠLOVÁ, Michaela
This thesis: "The current status of pediatrics nurse field and its impacts on practice" deals with actual problem and it means education of pediatrics nurses. There were set two targets: 1. Changes in pediatrics nurses field in time. 2. Detections of problems in education of pediatrics nurses that are caused by new changes in the study program. These targets were specified by four research points and three hypothesis yet. Implementation of research was carried by a combination of qualitative and quantitative research methods. Five head nurses participated to the research and then one hundred nurses from children's unit in hospital as well. Our research was divided in three parts. In the first there were made interviews with head nurses. We used semi - structured form. In second phase we spread our written survey in pediatrics nurses who are working in children's unit. It was created an online survey mainly for students of medical disciplines for comparison. In last phase there were analyzed documents of work load of nurses from children's unit. Results show that in practice there we are able to see many problems. Pediatrics nurses who completed their education in high school grow old. New ones are missed and it means that like pediatrics nurses work general nurses as well. In our survey we found out that nurses with different length of practice are the same opinion on education. Then that pediatrics and general nurses, who are working in children's unit perceive the problems equally. But nurses with different length of practice are different opinion on actual long of study. Final results of this thesis will be published in professional journal.
Radiation protection of pediatric radiodiagnostic
In my thesis I deal with ionizing radiation, its origin, its effects and principles. I also deal with radiation protection and its principles, medical exposure and pediatric radiodiagnostics in terms of imaging methods and specifics of radiation protection in paediatrics. And whether all the methods used to reduce radiation exposure in children undergoing ionizing radiation are used. Part of the work is also devoted to the way of communication in this area and awareness, whether it is paid enough attention or this area is neglected in the Czech Republic.
Radiation protection of pediatric radiodiagnostic
Due to the increase of number of ionizing radiation examinations in the pediatric population, it is important to focus on protecting them, as we assume that children have a long life ahead, and therefore the likelihood of a higher risk of ionizing radiation damage, where repeated use of ionizing radiation can cause irreversible changes of the organism. Therefore, the main objective is to evaluate and investigate the level of radiation protection both of professionals and of the general public.
Nursing care of child with juvenilie idiopathic arthritis
Bobitko, Julia ; Jeřábková, Lenka (advisor) ; Kulhavá, Miluše (referee)
Juvenile idiopathic arthritis is one of the most common rheumatic diseases that affects children less than 16 years of age. The illness is considered irrecoverable because of its unclear aetiology. My work is focused on nursing care of a child with juvenile idiopathic arthritis due to the very low awarness of this disease. The main objective was to describe the nursing care of a child with a given disease and to increase awareness of juvenile idiopathic arthritis. Another objective was to create information material for the public about the illness. I choose a case study method to meet these goals. I described the nursing process of the patient with the disease in the practical part of the bachelor thesis, supplemented by Mary Henderson model. Information was drew mainly from medical records, interviews with parents, medical staff, and by providing nursing care to the chosen patient. The specifics of nursing care of a child with juvenile idiopathic arthritis were described on the basis of the information and knowledge gained during the hospitalization of the patient. These informations were used also for creation the information material for the general public. keywords: juvenile idiopathic arthritis, nursing care, rheumatology, paediatrics nursing, arthritis

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