|
|
Fraud on Seniors - Prevention and Solution of the Problem in Context of Social Work
TURKOVÁ, Tereza
This bachelor thesis deals with fraud against the elderly and prevention from the perspective of social workers and police officers. The aim of the thesis is to find out what the current prevention by social workers and the Police looks like. The aim of the thesis is also to find out what kind of fraud occurs most often. The theoretical part of the thesis contains definitions of basic terms related to this topic. They were defined with the help of professional literature. The known types of under-fraud used by the perpetrators are described. The practical part was prepared in the form of qualitative research. Semi-structured interview was used as a technique. The interviews were conducted with police officers from the Press and Prevention Department of the South Bohemia Region. Furthermore, interviews were conducted with social workers working in social services focused on this issue.
|
|
| |
|
|
SWI2/SNF2 ATPases with a focus on the ISWI subfamily: protein complexes and mouse models for their study
Turková, Tereza ; Stopka, Tomáš (advisor) ; Janoštiak, Radoslav (referee)
In the nucleus the DNA is packed along with proteins into a dynamic structure called chromatin. During cell cycle the chromatin structure becomes a subject to various changes. During interphase chromatin structure becomes loose while shortly before cell division it undertakes the form of highly condensed mitotic chromosomes. Structure of chromatin influences significantly mode of gene expression and its pattern. DNA-binding proteins interacting within chromatin are also necessary during this process. To gain the access to the DNA binding factors, the chromatin has to be in a loosened form. As long as the structure of the chromatin is more condensed it creates a barrier for the DNA binding proteins. Therefore it becomes obvious that the remodeling of the chromatin structure is one of the important regulators of gene expression and that the enzymes, which execute remodeling, are of great importance. One of them is ATPase Smarca5, which belongs to the protein subfamily ISWI and which creates the catalytic subunit for several different ATP-dependent chromatin remodeling complexes. Mutations of members of those complexes disturb regulation of transcription and cellular differentiation. In some cases the incorrect function of these complexes can lead to cellular transformation into a tumours state. This...
|
|
|
Generation of the Mouse Model to Delineate Function of Chromatin Remodeling Gene Smarca5 (Snf2h)
Turková, Tereza ; Stopka, Tomáš (advisor) ; Dobeš, Jan (referee)
The chromatin structure, consisting of DNA and histones, changes dynamically during the cell cycle and cell differentiation. DNA can only be transcribed and replicated when it is packaged loosely, whereas tight packaging allows for more efficient storage. Chromatin remodelling is therefore one of the tools of gene expression control. The chromatin remodelling factors recognise chromatin with varying specificity and have an effect on the interaction between DNA and the histones. One of these factors is the Smarca5 protein. This study investigates the role of Smarca5; its goal is to create a mouse model with the ability to trigger Smarca5 overproduction in specific tissues. This model will be used to study the effect of a high, unregulated dose of Smarca5 on the physiological function of the protein. Previous studies have shown that non-physiological expression of a chromatin-remodelling factor can lead to malignant transformation. Our model can help to understand this process. Another goal of this study is to investigate some phenotype aspects of the mouse model with conditional deletion of Smarca5 in T and B cells, in particular the effects of this deletion on progenitor cell differentiation. Our results show that Smarca5 has an important role in lymphocyte development, and we have observed that...
|
|
|
SWI2/SNF2 ATPases with a focus on the ISWI subfamily: protein complexes and mouse models for their study
Turková, Tereza ; Stopka, Tomáš (advisor) ; Janoštiak, Radoslav (referee)
In the nucleus the DNA is packed along with proteins into a dynamic structure called chromatin. During cell cycle the chromatin structure becomes a subject to various changes. During interphase chromatin structure becomes loose while shortly before cell division it undertakes the form of highly condensed mitotic chromosomes. Structure of chromatin influences significantly mode of gene expression and its pattern. DNA-binding proteins interacting within chromatin are also necessary during this process. To gain the access to the DNA binding factors, the chromatin has to be in a loosened form. As long as the structure of the chromatin is more condensed it creates a barrier for the DNA binding proteins. Therefore it becomes obvious that the remodeling of the chromatin structure is one of the important regulators of gene expression and that the enzymes, which execute remodeling, are of great importance. One of them is ATPase Smarca5, which belongs to the protein subfamily ISWI and which creates the catalytic subunit for several different ATP-dependent chromatin remodeling complexes. Mutations of members of those complexes disturb regulation of transcription and cellular differentiation. In some cases the incorrect function of these complexes can lead to cellular transformation into a tumours state. This...
|
guest ::
RSS feed.