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Lineage plasticity of leukemic cells
Slámová, Lucie ; Mejstříková, Ester (advisor) ; Brdička, Radim (referee) ; Machová Poláková, Kateřina (referee)
So far, the lymphoid to myeloid lineage switch during the treatment of B cell precursor acute lymphoblastic leukemia (BCP ALL) was identified only rarely in patients with the MLL gene rearrangement. We discovered a novel BCP ALL subset switching to monocytoid lineage during an early phase of the treatment - swALL ("switching" ALL) with no MLL gene rearrangement. The proportion of swALL cases among BCP ALLs was unexpectedly high (3-4%). All swALLs have expressed the CD2 antigen (LFA-2). The upregulation of C/EBPα gene and hypomethylation of the CEBPA promoter were significant in blasts already at diagnosis, proceeding the lineage switch in the majority of the cases. SwALL patients were characterized by unique subpopulation of the cells coexpressing B lymphoid and monocytoid markers. Changes in the gene expression of M-CSFR, GM- CSFR and other genes accompanied the lineage switch. The lineage switch could be recapitulated in vivo and in vitro. Even if the children patient with swALL respond slowly to initial therapy, the prognosis is comparable to "other" BCP ALLs. Risk-based ALL therapy appears to be the treatment of choice for swALL. Powered by TCPDF (www.tcpdf.org)
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Lineage plasticity of leukemic cells
Slámová, Lucie ; Mejstříková, Ester (advisor) ; Brdička, Radim (referee) ; Machová Poláková, Kateřina (referee)
So far, the lymphoid to myeloid lineage switch during the treatment of B cell precursor acute lymphoblastic leukemia (BCP ALL) was identified only rarely in patients with the MLL gene rearrangement. We discovered a novel BCP ALL subset switching to monocytoid lineage during an early phase of the treatment - swALL ("switching" ALL) with no MLL gene rearrangement. The proportion of swALL cases among BCP ALLs was unexpectedly high (3-4%). All swALLs have expressed the CD2 antigen (LFA-2). The upregulation of C/EBPα gene and hypomethylation of the CEBPA promoter were significant in blasts already at diagnosis, proceeding the lineage switch in the majority of the cases. SwALL patients were characterized by unique subpopulation of the cells coexpressing B lymphoid and monocytoid markers. Changes in the gene expression of M-CSFR, GM- CSFR and other genes accompanied the lineage switch. The lineage switch could be recapitulated in vivo and in vitro. Even if the children patient with swALL respond slowly to initial therapy, the prognosis is comparable to "other" BCP ALLs. Risk-based ALL therapy appears to be the treatment of choice for swALL. Powered by TCPDF (www.tcpdf.org)
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Proposal of the Company's Financial Plan
Slámová, Lucie ; Poláček, Josef (referee) ; Sághy Estélyi, Kristína (advisor)
The Master´s thesis is concentrated to create long-term financial plan in the selected company. There are determined the goals of thesis in the first chapter, next part is focused on the theoretical basis of financial planning. The third part contains an analysis of the company and in the last part is described creation of the financial plan for years 2014 – 2016 and its evaluation.
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Baby after the weding - anachronism of nowadays
Slámová, Lucie ; Langhamrová, Jitka (advisor) ; Krbcová, Daniela (referee)
The thesis is focused on a family behavior in the Czech lands during past six decades. A reader learns the meaning and function of the family. Further attention is paid to fertility behavior with the emphasis on marital and extramarital fertility. This task answers the question whether the Czech society still respects classic family behavior, first wedding and after that a baby, using the theoretical background and data from the Czech Statistical Office. Supported by the data analysis we can recognize that the conservative behavior subsides. Influence of women income respectively the highest reached educational level has not been demonstrated.
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Analysis of fertility in the Czech Republic in selected periods within the context of political and social development
Slámová, Lucie ; Miskolczi, Martina (advisor) ; Šimková, Martina (referee)
The objective of the thesis is to analyze development of fertility in Czech Republic in selected time periods. There is a question of whether the important political and social changes affect the reproductive behavior of the population or not. The task is divided into two main parts. The first, theoretical part describes the historical background, political and social changes that occurred from 1940 to 2012. Also the theories of family policy and state support for families with children are described. The second part, practical one, is prepared by using data from Czech Statistical Office. Here are graphically illustrated demographic indicators mainly fertility, the average age of mothers and first-time mothers and the net reproduction rate. The observed data are then confronted with the historical context. The work suggests that significant social and political changes actually affect fertility. This effect, however, is only temporary. In the observed period, there was not such a strong impulse, which would affect the behavior of young families permanently.
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