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Up-scaling and further development of matrix liposomes
Skalická, Veronika ; Paraskevopoulos, Georgios (advisor) ; Holas, Ondřej (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate: Veronika Skalická Supervisor: Dr. Georgios Paraskevopoulos, Ph.D.; Michael Binnefeld Title of Diploma thesis: Up-scaling and further development of matrix liposomes The thesis evaluates novel matrix liposomes formed by dual asymmetric centrifugation technology. Particles' parameters (size, size distribution and ζ-potential) were analyzed by dynamic light scattering method using ZetaSizer device. Encapsulation efficacy was determined by size exclusion chromatography using carboxyfluorescein as fluorescent encapsulation marker. The overall results support that the most beneficial formulation parameters are 15 min of speed mixing process with ceramic beads of diameter 1,0-1,2 mm. Up-scaling of the procedure didn't drastically affect liposomal parameters up to a lipid batch load of 700 mg. Furthermore, the usage of different types of gelatin or glycerinated gelatin didn't significantly influenced particles' characteristics. It is noteworthy that the matrix composed of 50% glycerinated gel sustained the ability to form liposomes by dispersion of vesicular phospholipid gels in phosphate buffer saline even after 31 days. Other matrices showed a damage of liposomes as confirmed by size and size...
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Influence of ukrainian crisis on german economy and german russian relations
Skalická, Veronika ; Němcová, Ingeborg (advisor) ; Antal, Jarolím (referee)
The subject of my thesis is the impact of the Ukrainian crisis on German Russian relations and the German economy. Experts say that the deterioration of trade relations between the European Union and Russia caused by the Ukrainian crisis will also affect the economies of individual European countries. The deterioration in trade relations were caused by sanctions imposed in response to the crisis in Ukraine. The degree of impact of the Ukrainian crisis on a given country is directly proportional to the countrys interconnection with the Russia. Before the Ukrainian crisis began, Germany was Russias most active trading partner from the European Union. Germany also plays a significant role in the Ukrainian crisis, as a negotiator between the European Union and Russia. The influence of the Ukrainian crisis on the German economy is defined by the development of Germanys economic relations with Russia an important trading partner to Germany. Two economic indicators were used to assess the relationship: German-Russian commodity trading and German foreign direct investment in the Russian market. The development of trade between Germany and Russia was also analyzed within the individual economic sectors targeted by the sanctions. The impact of the Ukrainian crisis on the German economy was further assessed by the development of Germanys trade relati-ons with Ukraine and Belarus. The results of the analysis of economic indicators, which are in line with the information provided in expert sources, confirmed the negative impact of the Ukrainian crisis on German-Russian relations and the German economy. The negative impacts of the Ukrainian crisis on the German economy manifest in the form of financial losses caused by the decline in German exports to Russia and the poor economic situation of German investors in the Russian market. Due to the sanctions, some long-term projects between Germany and Russia were canceled, German companies operating in the Russian market experienced declining revenues, and these companies were forced to lay off workers.
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The Swiss economy in the early 21st century
Skalická, Veronika ; Jiránková, Martina (advisor) ; Bartušková, Hana (referee)
The bachelor thesis deals with the Swiss economy in the early 21st century. The economy of Switzerland is one of the most developed in the world, but recent events such as the eurozone debt crisis could threaten its position. The aim of this thesis is to analyse the current state of the Swiss economy, while defining the main sources of risks and predicting the future development of the Swiss economy. A significiant part of the thesis also focuses on the characteristics of each sector in Switzerland. The first chapter deals with the general characteristic of Switzerland and analysis of its current economy. The next chapter is focused on the sectors of economy, foreign trade and on the attitude of Switzerland to the issues of economic and politic integrations. The third part is devoted to the description of the prospects of the Swiss economy, within which I define the main sources of risks and suggest the measures to be taken to protect the Swiss economy from these risks. In this part I predict the future development of the Swiss economy, too.
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