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The influence of sertraline treatment on the metabolic and antropometric parameters in people with depression
Podlipný, Jiří ; Beran, Jiří (advisor) ; Filipovský, Jan (referee) ; Jirák, Roman (referee)
Introduction: Pharmacotherapy with antidepressants can cause a metabolic risk, can be neutral in terms of metabolism or can perform a metabolic benefit for the treated patients. Objective: The aim of the presented study is to assess the effects of long-term use of sertraline on the particular laboratory and anthropometric parameters in somaticaly healthy or compensated outpatients treated for unipolar depression. Methods: The study was performed in cooperation of Centre of Preventive Cardiology (CPC) of 2nd Department of Internal Medicine and Department of Psychiatry of Charles University in Prague, Faculty of Medicine in Plzeň (Pilsen) and University Hospital Plzeň, Czech Republic. A screening of risk factors in relation to the development of cardiovascular (CV) diseases and metabolic syndrom was carried out in 350 people from the cohort Pilsen Longitudinal Study III (PILS III) at CPC. The participants filled in a Czech version of the Zung Self-Rating Depression Scale (SDS) simultaneously with the screening. Those of them scoring up the threshold set for the suspicion of depression in SDS were invited to the department of psychiatry outpatient's office in order to undertake a psychiatric examination. There were 31 persons in total fulfilling the following criteria: (1) aduld patients diagnosed with...
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Cognitive remediation using virtual reality in neuropsychiatric disorders
Plechatá, Adéla ; Hocko Fajnerová, Iveta (advisor) ; Podlipný, Jiří (referee) ; Nikolai, Tomáš (referee)
Theoretical background: This dissertation investigates the feasibility of virtual reality (VR) for cognitive remediation in neuropsychiatric patients. The main goal was to create VR tasks appropriate for this purpose, assess the characteristics of the applied VR media, and investigate the validity and efficacy of the developed program in the target population. Method: In Study 1, healthy seniors (n = 36) and young adults (n = 25) participated in a newly developed Virtual Supermarket Shopping Task (VSST) in immersive VR (IVR) or non-immersive VR (non-IVR) to investigate their characteristics. Study 2 assessed validity (n = 21) and reliability (n = 8) of a novel VR task focused on psychomotor speed called Flies. In Study 3, VSST was administered to 20 patients with schizophrenia (SZ) and 20 healthy controls (HC) to investigate its validity. Finally, in Study 4, 28 patients with schizophrenia or depression participated in the proposed VE program and standard paper-pencil remediation approach to investigate feasibility and efficacy. Results: In Study 1, the seniors performed significantly worse in IVR than in non-IVR, cognitive performance in young adults was stable across different VR media, the young adults preferred IVR over non-IVR. Study 2 found a significant correlation between the Flies and...
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The influence of sertraline treatment on the metabolic and antropometric parameters in people with depression
Podlipný, Jiří ; Beran, Jiří (advisor) ; Filipovský, Jan (referee) ; Jirák, Roman (referee)
Introduction: Pharmacotherapy with antidepressants can cause a metabolic risk, can be neutral in terms of metabolism or can perform a metabolic benefit for the treated patients. Objective: The aim of the presented study is to assess the effects of long-term use of sertraline on the particular laboratory and anthropometric parameters in somaticaly healthy or compensated outpatients treated for unipolar depression. Methods: The study was performed in cooperation of Centre of Preventive Cardiology (CPC) of 2nd Department of Internal Medicine and Department of Psychiatry of Charles University in Prague, Faculty of Medicine in Plzeň (Pilsen) and University Hospital Plzeň, Czech Republic. A screening of risk factors in relation to the development of cardiovascular (CV) diseases and metabolic syndrom was carried out in 350 people from the cohort Pilsen Longitudinal Study III (PILS III) at CPC. The participants filled in a Czech version of the Zung Self-Rating Depression Scale (SDS) simultaneously with the screening. Those of them scoring up the threshold set for the suspicion of depression in SDS were invited to the department of psychiatry outpatient's office in order to undertake a psychiatric examination. There were 31 persons in total fulfilling the following criteria: (1) aduld patients diagnosed with...
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