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Production of ceiling light
Kvasnička, Jan ; Řiháček, Jan (referee) ; Císařová, Michaela (advisor)
The manufactured component is the inner part of the ceiling lamp. It is made of 17 240 steel in a series of 100 000 pieces/year. A combination of tool cutting and deep drawing without thinning the wall was chosen from the possible production technologies. The diameter of the blank from which the resulting shape is pulled out was calculated to be 400 mm. It will be cut from an unwound coil of sheet metal, the inner diameter of which is 400 mm and the outer 1000 mm. A drawing tool was designed for forming and it's functional parts were made of 19 436 steel. The tool is placed in hydraulic three-acting press PO 160/100 from company Dieffenbacher. The press is part of a line which includes an unwinding device, a straightening device and a cutting tool.
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Analysis of echocardiographic findings in patients with primary and secondary hypertension using new sophisticated modalities
Kvasnička, Jan ; Holaj, Robert (advisor) ; Wohlfahrt, Peter (referee) ; Danzig, Vilém (referee)
6 Abstract Introduction: Heart damage in essential hypertension (EH) is one of the most serious consequences of high blood pressure. However, in the case of secondary hypertension, multiple pathophysiological effects may apply. For example, pheochromocytomas (PHEOs), which are tumors arising from the chromaffin cells of the adrenal medulla, have the ability to produce, metabolize, and secrete catecholamines. Overproduction of catecholamines leads to cardiac and other impairments by many mechanisms. The aim of our work was to verify this fact and at the same time to investigate whether global longitudinal strain (GLS), measured using speckle tracking echocardiography, can detect this damage earlier and also determine the adjustment of function after adrenalectomy. Methods: We analyzed 17 patients with PHEO and 18 patients with EH with the same hemodynamic parameters. Subsequently, we managed to increase the number of patients with PHEO to 24, and they were also examined 1 year after adrenalectomy. Results: Patients with PFEO did not differ in echocardiographic parameters including left ventricular ejection fraction compared to EH (0.69 ± 0.04 vs. 0.71 ± 0.05; NS), however, they had significantly lower GLS (−14.8 ± 1.5 vs. −17.8 ± 1.7; p < 0.001). One year after adrenalectomy, the GLS parameter improved...
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Production of ceiling light
Kvasnička, Jan ; Řiháček, Jan (referee) ; Císařová, Michaela (advisor)
The manufactured component is the inner part of the ceiling lamp. It is made of 17 240 steel in a series of 100 000 pieces/year. A combination of tool cutting and deep drawing without thinning the wall was chosen from the possible production technologies. The diameter of the blank from which the resulting shape is pulled out was calculated to be 400 mm. It will be cut from an unwound coil of sheet metal, the inner diameter of which is 400 mm and the outer 1000 mm. A drawing tool was designed for forming and it's functional parts were made of 19 436 steel. The tool is placed in hydraulic three-acting press PO 160/100 from company Dieffenbacher. The press is part of a line which includes an unwinding device, a straightening device and a cutting tool.
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Incidence and prevention of first episodes of deep venous thrombosis in patients with mutation factor V Leiden
Chocová, Zdeňka ; Kvasnička, Jan (advisor)
Deep venous thrombosis (DVT) is 3 most cardiovascular disease is one of the most frequent disease at all. In the CR year clinically Diagnosed 15 000-25 000 cases 2 DVT. Despite a number of active tools for the prevention of venous thrombosis is still facing high prevalence of the disease. Epidemiological studies EPI-GETBO 5 of 2000, proves this fact or findings venographically duplex ultrasound proven DVT. By monitoring the 340 000 persons during 1 year was 1.24 cases detected DVT and 0.6 case of pulmonary embolism per every 1000 monitored persons. For people aged over 75 years the incidencesharply increases, DVT has been diagnosed in every hundredth person. In clinical practice still faces many factors that contribute a high incidence of DVT. These include increasing the number ofoccurrence malignant disease that is accompanied by secondary thromboembolism, or mass distribution of some protrombofilních medication. The fault may also be yet undiscovered genetic predisposition for venous thrombophilia or some infectious agents. On the other hand, the total number of detected cases reflect improved diagnosis of these conditions 7 . Advances in diagnosis using modern methods of molecular Genetics reveals another important risk factor - an inherited thrombophilia. These also include the factor V Leiden...
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Comparison of control measurements on different types of analyzers used in ÚKBLD CHLTC of VFN in Prague
Koblasa, Vladimír ; Kvasnička, Jan (advisor) ; Kozák, Tomáš (referee)
Koblasa,Vladimír - Comparison of control measurements on various types of haematology analyzers used by ÚKBLD CHLTC at University Hospital in Prague First Faculty of Medicine, Charles University in Prague, Praha 2, Kateřinská 32 Head of the work: prof. MUDr. Jan Kvasnička, DrSc. Supervisor -consultant: Mgr. Ivana Malíková Blood cell count is essential testing method in hematology, where it is necessary to ensure properquality control. Aim of this study was to compare the results of measurement control materials with defined parameters and the same samples at different haematological analyzers to obtain evidence for the expression of measurement uncertainties. There are used more types of blood analyzers in ÚKBLD CHLTC at University Hospital in Prague, which operate on different principles. For comparsion were selected analyzers using the impedance working principle, where individual blood cell passes between two electrodes controlled by low voltage. Variation of this voltage is recorded and accurately defined for each type of blood cells. It was also chosen analyzer that works with optical detection. Analyzer illuminates the individual blood cell by light beam. A cell that enters into the path of light rays, reduce its optical density incident on the photocell. The change of the light density...
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Public debt and household debt
Kvasnička, Jan ; Gregor, Martin (advisor) ; Schneider, Ondřej (referee)
In this thesis, we analyse both the theoretical and the empirical determinants of household debt and public debt, or, more generally, the determinants of saving of these entities. A short survey of the relevant theoretical and empirical literature is presented in the opening chapters. In the second part of the thesis, the tax smoothing model is extended by abandoning the assumption of a benevolent social planner. The main result of the model is a demonstration of the fact, that voters can vote over public budget decits in order to shift relatively high taxation of income into periods in which their income is relatively low. Through this channel, changes in income inequality can be indirectly reflected in public saving.
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Thrombophilia and thrombotic complications in severe septic patients
Zenáhlíková, Zuzana ; Kvasnička, Jan (advisor) ; Maruna, Pavel (referee) ; Malý, Jaroslav (referee)
Introduction: Thrombotic events are among the most serious complications of sepsis and also the most frequent causes of morbidity and mortality in patients with sepsis. Currently, the administration of low molecular weight heparins (LMWH) is recommended in patients with severe sepsis for prophylaxis of these complications. However, this prophylaxis often fails. Objectives of the study: One of the objectives of our study was to examine changes in haemostasis in relation to the inflammatory response during 15 days of severe sepsis. The next objective was to determine whether a prophylactic inhibition of F Xa in the range from 0.2 to 0.4 IU/mL is achieved in these patients, if they receive the recommended prophylaxis with LMWH. We also recorded the dynamics of changes in the F Xa inhibition during the entire study period. Moreover, we tried to identify the factors that may affect the antithrombotic efficacy of the subcutaneously administered enoxaparin. Patient population and methods: A total of 35 ICU patients meeting the criteria of severe sepsis were enrolled in the study. Only 16 of these patients could be followed throughout the entire 15-day period. Patients were treated according to the current guidelines, including LMWH prophylaxis; enoxaparin (40 mg sc per day) was used in this study....
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název v anglickém jazyce není uveden
Belošovičová, Hana ; Calda, Pavel (advisor) ; Hyánek, Josef (referee) ; Kvasnička, Jan (referee)
Souhrn Cíl: Stanovit hladiny celkového plazmatického cysteinu, homocysteinu, cysteinylglycinu a glutathionu u normotenzních primigravid ve druhém a třetím trimestru a porovnat je s hladinami u těhotných s následným rozvojem preeklampsie. Metodika: Do studie bylo zařazeno 65 zdravých primipar. U každé těhotené byl nabrán vzorek krve v 19.-21. a 30.-32. týdnu těhotenství. Hladiny celkového plazmatického cysteinu, homocysteinu, cysteinylglycinu a glutathionu byly stanoveny HPLC metodou. Hladiny aminothiolů v druhém a třetím trimestru byly porovnány pomocí párového t testu. Hladiny cysteinu u těhotných byly porovnány s hladinami cysteinu u kontrolního souboru netěhotných žen. Výsledky: Hladina celkového plazmatického cysteinu u normotenzních těhotných byla signifikantně nižší ve třetím trimestru v porovnání strimestrem druhým (medián 176.1 |amol/l [163.0, 189.4] versus 187.4 |amol/l [178.7, 205.2], P < 0.001). Hladiny ostatních aminothiolů se nelišily. U třech z 65 těhotných došlo k rozvoji mírné preeklampsie. Hodnoty t-Cys ve třetím trimestru u těhotných s následným rozvojem preeklampsie vykazovaly nárůst nebo menší pokles než u normotenzních těhotných. Závěr: Celkový plazmatický cystein je signifikantně nižší ve třetím trimestru než v trimestru druhém. Tento pokles je pravděpodobně dán spotřebou cysteinu...
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Haemocoagulation changes caused by cardiopulmonary bypass
Šnircová, Jana ; Vaněk, Tomáš (advisor) ; Kvasnička, Jan (referee) ; Kunstýř, Jan (referee)
The aim of preliminary and experimental prospective, randomized study was to search for thromboelastography signs of fibrinolysis, their impact on postoperative blood loss and need of transfusion in coronary surgery. In preliminary study we had compared results in 20 patients scheduled for coronary surgery (10 patients OPCAB, 10 patients conventional CABG). Completely expressed thromboelastographic signs of hyper-fibrinolysis had been detected in 2 on-pump patients and partial signs of increased fibrinolytic activity had been noticed in other 2 patients originating from the same group, unlike OPCAB group, in which no signs of fibrinolysis had been observed. However, differences between the evaluated groups in that trial had not reached statistical significance due to a small number of study subjects. In experimental study, 65 patients scheduled for coronary surgery were randomized into three groups: A - conventional coronary artery bypass grafting, B - off-pump surgery, C - coronary artery bypass grafting with modified, rheoparin coated ardiopulmonary bypass with the avoidance of re-infusion of cardiotomy blood into the circuit. On the completion of peripheral bypass anastomoses, highly significant inter-group differences were found in the thromboelastographic parameter lysis of set time at 60 min of...
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