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Quality of life of a child with a rare skin disease
KOUBOVÁ, Michaela
This diploma thesis deals with a rare skin condition called Ichthyosis which is, for the majority of the population, unknown. It is a rare genetic disease that is manifested via a different skin look and a bad bodily thermoregulation. The aim of this thesis is to map out the specific needs in the lives of children suffering from this disease and to point out the aspects of life quality for children thus diagnosed and their families, too. The theoretical part deals with the history, diagnosis, symptom description, the causes of origin as well as care for an individual suffering from this illness. To fulfil the aims of the practical part qualitative research was chosen in the design of a case study focused on a description of complex care and subjective understanding of quality of life in addressed individuals suffering from the given illness and their families.
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Person with Teacher Collins syndrom in context with coordinated care and quality of life, case study
KOUBOVÁ, Michaela
Bachelor thesis deals with the issue of Treacher Collins syndrome. Treacher Collins Syndrome is a rare genetic disease that is distinctly manifested by deformities in the face. Due to the different appearance and ignorance of the syndrome, it is difficult, for the public, to integrate individuals into society. These factors impede the mental well-being of both the individual and his family. This work is divided into theoretical and research part. In the theoretical part, the subject of this syndrome is elaborated based on relevant sources, so that the reader be well versed in this issue. It deals with the definition of Treacher Collins syndrome, its history, description of symptoms, and causes. The thesis also mentions methods of prenatal diagnosis and the development of such an individual. The next part focuses on comprehensive care of individuals. It includes special pedagogical care, health and social care. It deals primarily with the education of individuals, surgical interventions, compensatory aids, and the integration of individuals with Treacher Collins syndrome into society. The research part consists of a case study of a specific individual with Treacher Collins syndrome and his family. This part has been aimed to obtain and process information concerning the state of health, personal and family case history, available medical care, education, interests and life quality of the individual and his family. An in-depth interview and analysis of specific documents were used to obtain data. The research revealed a lot of interesting information. It turned out that the quality of life is influenced by levels of parental competencies, quality of health care, and the functionality of integration into the education system.
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Werenwolves in European culture context
Koubová, Michaela ; Czumalo, Vladimír (advisor) ; Opletalová, Lenka (referee)
We have met a motif of the werewolf in the course of the whole European cultural history. Already ancient authors - poets, historians and doctors, as well, devoted themselves to study of this phenomenon. In particular, a zone of Arcadia and its mythical king Lykaon were the most emblazoned with werewolf myths. German ulfhednars and quantity of Slavic superstitions show that belief in werewolves was widespread among the other European nations. Even in Middle Ages werewolves did not fall into oblivion, and there dealt with them not only religious literature, but also belles lettres - of which poem Bisclaveret of Maria de France is probably the most famous. Actual expansion and intensification of belief in werewolves occurred in the early modern age, owing to that many paid life. Werewolfness was particularly in France a widespread crime. Work of religious and other authors on whether and how the metamorphosis of humans in the animal is possible, we can see up to the late modern times. A different view, however, remained doctors, who since antiquity claimed that lykantropia is a kind of melancholy, and therefore a mental illness. Of the many superstitions and myths, the theme was taken over by literature and later by film in 19th and especially in 20th century. Flood of horrors and fantasy, which we can meet...
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Imposing punishments on adults
Koubová, Michaela ; Heranová, Simona (advisor) ; Mulák, Jiří (referee)
Imposing punishments on adults Abstract This thesis deals with the imposition of punishments on adult offenders. The introductory chapters are devoted first to the definition of the concept of punishment and its position in relation to protections measures, and then to the system of punishment, within which the different types of punishment and their classification according to various criteria are discussed. A substantial part of the work is devoted to the interpretation of the issue of the purpose of punishment, which is the starting point for the imposition of punishment. The purpose of punishment is described using the three main theories of punishment, namely retributive, utilitarian and mixed theories. These theories, their approach to the purpose of punishment and their historical development are discussed in more detail, including their various modifications. This chapter also deals with the purpose of punishment in the Czech legal system and, in connection, with the question of the primary and secondary purpose of punishment. This chapter also includes a separate discussion of the issue of general and individual prevention, which is important in terms of distinguishing the different approaches to the purpose of punishment according to the above-mentioned theories of punishment. Closely related to...
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Immunohistochemical analysis of SMAD proteins expression in experimental atherogenesis.
Koubová, Michaela ; Mičuda, Stanislav (referee) ; Nachtigal, Petr (advisor)
Michaela Koubová Immunohistochemical analysis of SMAD protein expression in experimental atherogenesis Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Pharmacy Background: The aim of this diploma thesis was to analyze SMAD 2/3 expression in mice atherosclerosis lesions and find differences in the expression between animals feeding with standard diet and diet with addition of atorvastatin. The aim was demonstrate whether atorvastatin influences SMAD 2/3 expression without hypolipidemic effects. Methods: Female C57BL/6J apolipoprotein E and LDL-receptor double deficient mice were used in the study. Biochemical analysis of blood samples, histological and immunohistochemical analysis of aorta were performed. For identification of SMAD 2/3 expression was used EnVision method with DAB visualization. Results: Biochemical analysis revealed that the eight-week administration of atorvastatin resulted in a statistically significant increase in total cholesterol. Histological analysis showed that administration of atorvastatin resulted in significant reductions in the size of atherosclerotic plaques compared with untreated group.Immunohistochemical analysis showed SMAD 2/3 expression in atherosclerotic plaques in both groups.Significant differences in the expression of SMAD...
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