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Cardiovascular Risks in Chronic Airway Disease in Childhood
Kreslová, Marcela ; Sýkora, Josef (advisor) ; Fila, Libor (referee) ; Kopřiva, František (referee)
1 Cardiovascular risks in chronic airway disease in childhood The aim of this thesis was to evaluate cardiovascular risk by using a combined diagnostic approach by measuring RHI and specific biochemical markers in patients with chronic respiratory disease, where we could assume a possible risk of CVD. A total of 119 probands were examined, including 22 patients with cystic fibrosis (CF) and 52 asthma patients. We evaluated RHI using a new plethysmographic method that has a number of advantages over the ultrasonographic methods used in other studies, including non-invasiveness, high sensitivity, low biological variability and objectivity due to automatic processing. Of the biochemical parameters, we measured 4 biomarkers in relation to endothelial dysfunction (ED): hsCRP, ADMA, E-selectin, and VCAM-1. We compared RHI and biomarkers in CF and asthma patients with healthy controls and sought mutual correlations. We did not prove a statistically significant difference in RHI between the test groups with CF children but we confirmed the decreasing trend of RHI since adolescence and significantly lower RHI values in CF adults, confirming the progressive development of atherogenesis and worsening of ED with age. Biochemical parameters showed significantly higher levels of hsCRP, sVCAM-1 and E-selectin in CF...
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Observation of postural and respiratory functions in adult patients with cystc fibrosis
Yaghi, Ammar ; Smolíková, Libuše (advisor) ; Fila, Libor (referee)
Thesis objective: This thesis focuses on postural and respiratory functions in adult patients with cystic fibrosis. Furthermore, it studies observations of common features in body posture. Finally, this thesis tries to evaluate life quality of patients with cystic fibrosis despite the fact of small experimental sample group used. Methods: between the years 2013 and 2014, 10 adult patients with cystic fibrosis diagnosis who were hospitalized at the department of tuberculosis and respiratory diseases at Motol hospital were examined. All examined patients belonged to the age category 18 to 30 years old. Methods used in examining the patients included spirometry, spine dynamic test, posture assesment software and at the end of all examinations a standardized questionnaire was given to all patients to evaluate the life quality of patients with CF (questionnaire of cystic fibrosis). Results: a common manifestation was the barrel-shaped thorax that increases its size in the anteroposterior direction, which causes thoracic kyphosis, shoulder protraction, stiffness of the ribcage and hyperlordosis of the lumbar spine. Conclusion: Patients with cystic fibrosis are to be found in all ranges of pulmonary functions. The most common complaint is the cough that distinctly affects their life quality (sleep...
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The importance of determination of oxidative stress markers in exhaled breath condensate for the assessment of lung disease progression in patients with cystic fibrosis
Fila, Libor ; Kolář, Pavel (advisor) ; Macek, Milan (referee) ; Vondra, Karel (referee)
The aim of this study was to evaluate the relationship of oxidative stress (OS) marker s in exhaled breath condensate (EBC) in adult patients with cystic fibrosis (CF) to the severity of lung disease, nutritional status and systemic antioxidants and inflammatory markers, as well as to short - and medium - term development of pulmonary function and nutritional status, and finally to assess the response to treatment with inhaled corticosteroids (ICS). Methods: CF patients were examined in a stable phase of the disease during routine outpatient controls. EBC was collected using E C oScreen device (J aeger) in CF patients and in control group members. Nitrites and nitrates and 8 - isoprostane were examined using liquid chromatography and competitive enzyme immunoanalysis, respectively, in EBC as OS markers. Demographic data including the dominant pathogen of airway colonization and ICS treatment were recorded in CF patients. Lung function tests, chest X-ray s, nutritional statuses and systemic antioxidants and inflammatory markers were also examined using standard methods. The values of OS markers in EBC in patients with CF were compared with the control group and correlated to clinical parameters. Lung function tests and nutritional status es in CF patients were examined in one, three and five years intervals...
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