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The importance of field wetlands in agricultural landscapes
Šumberová, Kateřina ; Vymyslický, T. ; Fabšičová, Martina ; Fránková, Markéta
Field wetlands represent an extremely valuable biotope in agricultural landscapes, not only in terms of water management, but also in terms of biodiversity of various groups of organisms. Species living in these habitats survive adverse periods in the form of seeds, spores and eggs in the soil, many of them belonging to endangered groups of organisms. Our research has yielded in new findings of rare vascular plant species, as well as interesting findings of diverse species of micro- and macroscopic algae. Among the most important findings are some thermophilic and slightly halophilic vascular and algae species, whose occurrence in our country is mainly linked to southern Moravia. Seventeen plant species from the current Red List were found, three species in the critically endangered category (C1: Hibiscus trionum, Pulicaria dysenterica, P vulgaris), six species in the severely endangered category (C2: Lythrum hyssopifolia, Malva pusilla, Rumex tenophyllus, Schoenoplectus tabernaemontani, Veronica anagalloides), five species in the endangered category (C3: Centaurium pulchellum, Cyperus fuscus, Lemna trisulca, Lotus tenuis, Veronica catenata) and five rarer species requiring attention (C4: Bolboschoenus laticarpus, B planiculmis, Butomus umbellatus, Limosella aquatica, Schoenoplectus lacustris). The vegetation at the study sites could be classified into five syntaxonomic classes: Lemnetea, Potametea, Isoëto-Nanojuncetea, Bidentetea tripartitae and Phragmito-Magnocaricetea. Vascular plants were represented by several ecological groups: annual wetland plants, perennial species of reed beds and wet disturbed grasslands, hydrophilous weeds and ruderal species, and aquatic plants. Macroscopic algae were represented primarily by filamentous green algae of the genera Cladophora, Spirogyra and Oedogonium, and to a lesser extent by the genus Vaucheria spp., and by cyanobacteria (Nostoc spp.). The representatives of the genus Chara inhabited wetlands with longer periods of inundation. Diatoms (Achnanthidium, Amphora, Gomphonema, Navicula, Nitzschia, Pinnularia, Surirella and Tryblionella) were the most quantitatively represented and species-rich group of microalgae in the studied wetlands, followed by the genera Colacium, Euglena and Trachelomonas, by green algae (Desmodesmus), and by cyanobacteria (Homoeothrix and Phormidium).There was a high variability in the number of vascular plants and overall species composition, as well as in the representation of different algal groups and their species richness. Large changes were evident between and within years.
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Effect of sunitinib on the expression of P-selectin in normotensive and hypertensive rats
Šumberová, Kateřina ; Nachtigal, Petr (advisor) ; Kovařík, Miroslav (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Mgr. Kateřina Šumberová Consultant: Doc. PharmDr. Petr Nachtigal, Ph.D. Title of Thesis: Effect of sunitinib on the expression of P-selectin in normotensive and hypertensive rats Background: The objective of this thesis was to prove the P-selectin expression as a potential predictive marker of ongoing endothelial dysfunction. The experiments based on the application of cytostatic sunitinib were carried out on the aorta of spontaneously hypertensive rats (SHR) as well as normotensive rats (WKY). Methods: Two groups of rats were subject of testing in this experiment - male SHR and WKY rats - both groups were divided into two subgroups. While the first subgroup of rats was fed by sunitinib from the beginning of the experiment, the second subgroup (a control group) was fed by placebo. The scheme of application of sunitinib to the SHR strain consisted of 8 weeks of application - 5 days without application - 8 weeks of application. In the case of WKY rats, the last stage of the scheme was shortened due to toxicity, thus 8 weeks of application - 5 days without application - 2 weeks of application. We applied imunohistological analysis ABC of the aortic endothels using DAB as a chromogen....
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Influence of transforming growth factor (TGF) beta 1 and endoglin on atherogenesis.
Šumberová, Kateřina ; Kudláčková, Zděnka (advisor) ; Nachtigal, Petr (referee)
Author: Kateřina Šumberová Title of diploma thesis: Význam transformujícího růstového faktoru beta 1 a endoglinu v aterogenezi Diplomová práce Charles University in Prague Faculty of Pharmacy in Hradec Králové Field: Pharmacy Abstract Background: Objective of this diploma thesis is background research using available knowledge about atherosclerosis, TGF - β1 (Transforming growth factor - β1) and endoglin and about their roles in atherogenesis. Main findings: TGF - β1 promotes atherosclerotic plaque stability, acts as antiinflammatory agent and prevents from development and progression of atherosclerosis. However, at the same time TGF - β1 restricts endothelial regeneration, lowers production of vasodilators whereas TGF - β1 promotes production of vasoconstrictors in blood vessel wall. TGF - β1 supports initiation and progression of hypertension contributing to more progressive atherogenesis. Endoglin is a transmembrane protein, a component of the TGF - β receptor komplex and modulates its signalisation. According to recent studies is considered antiatherogenic action of endoglin to blood-vessel endothelium. Conclusions: These results demonstrate that the role of TGF - β1 and endoglin in atherogenesis remains still unclear. Further investigation is neccesary for determination of exact mechanisms and roles of...
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Three years long investigation of fishpond Dehtář - first fishpond in the NETLAKE COST action project
Potužák, Jan ; Šumberová, Kateřina ; Fránková, Markéta ; Fabšičová, Martina ; Ducháček, M. ; Císař, K. ; Duras, J.
In 2014–2016 we monitored basic environmental parameters in the fishpond Dehtář near České Budějovice (Czech Republic) using system of sensors. Among other parametres we studied for instance water chemistry and phyto- and zooplankton community biomass, and species composition. Thank to the method used we recorded strong fluctuations in some of the environmental parameters, parrticularly in oxygen concentrations. Thank to the integration of the auomatic high frequency monitoring using the sensor system along with traditional research methods we were able to interpret the marked ecosystem changes. Several factors participated in the several days long oxygen depletion: warm and calm weather, later interchanged by cold front accompanied with mixing of water column and cloudy sky, fish farming management (high amount of nutrients related to manuring) and changes in biomass of phytoplancton (fast decomposition of high biomass amount of cyanobacteria). Our results enable to prevent similar situations in future, by e.g. lowering of nutrient input.
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Effect of sunitinib on the expression of P-selectin in normotensive and hypertensive rats
Šumberová, Kateřina ; Nachtigal, Petr (advisor) ; Kovařík, Miroslav (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Mgr. Kateřina Šumberová Consultant: Doc. PharmDr. Petr Nachtigal, Ph.D. Title of Thesis: Effect of sunitinib on the expression of P-selectin in normotensive and hypertensive rats Background: The objective of this thesis was to prove the P-selectin expression as a potential predictive marker of ongoing endothelial dysfunction. The experiments based on the application of cytostatic sunitinib were carried out on the aorta of spontaneously hypertensive rats (SHR) as well as normotensive rats (WKY). Methods: Two groups of rats were subject of testing in this experiment - male SHR and WKY rats - both groups were divided into two subgroups. While the first subgroup of rats was fed by sunitinib from the beginning of the experiment, the second subgroup (a control group) was fed by placebo. The scheme of application of sunitinib to the SHR strain consisted of 8 weeks of application - 5 days without application - 8 weeks of application. In the case of WKY rats, the last stage of the scheme was shortened due to toxicity, thus 8 weeks of application - 5 days without application - 2 weeks of application. We applied imunohistological analysis ABC of the aortic endothels using DAB as a chromogen....
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Influence of transforming growth factor (TGF) beta 1 and endoglin on atherogenesis.
Šumberová, Kateřina ; Nachtigal, Petr (referee) ; Kudláčková, Zděnka (advisor)
Author: Kateřina Šumberová Title of diploma thesis: Význam transformujícího růstového faktoru beta 1 a endoglinu v aterogenezi Diplomová práce Charles University in Prague Faculty of Pharmacy in Hradec Králové Field: Pharmacy Abstract Background: Objective of this diploma thesis is background research using available knowledge about atherosclerosis, TGF - β1 (Transforming growth factor - β1) and endoglin and about their roles in atherogenesis. Main findings: TGF - β1 promotes atherosclerotic plaque stability, acts as antiinflammatory agent and prevents from development and progression of atherosclerosis. However, at the same time TGF - β1 restricts endothelial regeneration, lowers production of vasodilators whereas TGF - β1 promotes production of vasoconstrictors in blood vessel wall. TGF - β1 supports initiation and progression of hypertension contributing to more progressive atherogenesis. Endoglin is a transmembrane protein, a component of the TGF - β receptor komplex and modulates its signalisation. According to recent studies is considered antiatherogenic action of endoglin to blood-vessel endothelium. Conclusions: These results demonstrate that the role of TGF - β1 and endoglin in atherogenesis remains still unclear. Further investigation is neccesary for determination of exact mechanisms and roles of...
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