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Case study of the Physiotherapeutic Treatment of a Patient Diagnosed with Nervus Peroneus Paresis
Šímová, Lenka ; Reckziegelová, Petra (advisor) ; Štěpánková, Šárka (referee)
Title: Case study of the Physiotherapeutic Treatment of a Patient Diagnosed with Nervus Peroneus Paresis Aims: Acquisiting theoretical and practical knowledge of peripehral paresis, especially the peripheral paresis of nervus petroneus, followed-up by elaborating a casuistry of a patient diagnosed with a selected diagnosis created over the duration of practical training. Methodology: The general part of this bachelor thesis contains theoretical findings about anatomy of the peripheral nervous system, peripheral paresis clinical image, treatment and follow-up therapy. The special part contains a description of selected physioterapeutic methods in practice. Results: Reduction of a degree of shortening of selected muscles, elimination of reflexive mutations of soft tissues, renewal of joint play and strength enhancement of selected weakened muscles. Conclusion: Physiotheraphy is an integral part of peripheral paresis treatment. Key words: physiotherapy, neurology, paresis, peroneus, rehabilitation
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Effect of cholinesterase inhibitors on monoaminergic system and energic metabolism
Kalinová, Tereza ; Mladěnka, Přemysl (advisor) ; Štěpánková, Šárka (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Tereza Kalinová Supervisor: Assoc. Prof. Přemysl Mladěnka, Pharm.D., Ph.D. Mentor: Assoc. Prof. Jana Hroudová, Pharm.D., Ph.D. Title of diploma thesis: Effect of cholinesterase inhibitors on monoaminergic system and energy metabolism Cholinesterase (ChE) inhibitors play an essential role in the treatment of Alzheimer's disease (AD). They effect positively cognitive, functional and behavior symptoms of AD. Up to date, donepezil, rivastigmine and galantamine represent the only ChE inhibitors approved for AD treatment. The first ChE inhibitor was tacrine, which was withdrawn from market due to its toxicity and adverse effects. Recently, novel tacrine and 7-methoxytacrine (7-MEOTA) derivatives were synthetized and extensively investigated to find less toxic compounds affecting pathological mechanisms associated with development of AD. There is less known about effects of these drugs on mitochondrial functions and cellular energy metabolism. The aim of this project is to examine in vitro effects of ChE inhibitors on energy metabolism and cellular respiration, specifically on mitochondrial electron transport chain complexes and an enzyme of the citric acid cycle - citrate synthase. Inhibitory effects...
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Changes in blood pressure during group remedial exercise in cardiac patients
Štěpánková, Šárka ; Daďová, Klára (advisor) ; Majorová, Simona (referee)
3 Title of the thesis: Changes in blood pressure during group remedial exercise in cardiac patiens Objektive: The aim of this thesis was to describe the changes in blood pressure during remedial exercises. Method: There were 11 females participating in the study, all of senior age and suffering cardiovascular conditions. The exercise unit was intentionally selected to suit treated cardiac patients. The blood pressure readings were taken during the one-hour exercise units at Motol Faculty Hospital. Mercury tonometers were used for the measurements and readings. Results: During the exercise, average systolic blood pressure readings ranged between 137,73 mm Hg and 183 mm Hg, (± SD 28,99) ,diastolic blood pressure ranged between 85,91 mm Hg and 100,45 mm Hg, (± SD 18,88), and pulse rate was between 69 and 77. In four of the tested subjects the systolic blood pressure exceeded 200 mm Hg during the exercise. The highest blood pressure readings were taken when lying down, after a dynamic warm-up, and during lying on the back while moving one leg vigorously. Key words: Blood pressure, cardiovascular disease, remedial exercise, measuring blood pressure.
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Effect of cholinesterase inhibitors on monoaminergic system and energic metabolism
Nowak, Tereza ; Mladěnka, Přemysl (advisor) ; Štěpánková, Šárka (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Tereza Kalinová Supervisor: Assoc. Prof. Přemysl Mladěnka, Pharm.D., Ph.D. Mentor: Assoc. Prof. Jana Hroudová, Pharm.D., Ph.D. Title of diploma thesis: Effect of cholinesterase inhibitors on monoaminergic system and energy metabolism Cholinesterase (ChE) inhibitors play an essential role in the treatment of Alzheimer's disease (AD). They effect positively cognitive, functional and behavior symptoms of AD. Up to date, donepezil, rivastigmine and galantamine represent the only ChE inhibitors approved for AD treatment. The first ChE inhibitor was tacrine, which was withdrawn from market due to its toxicity and adverse effects. Recently, novel tacrine and 7-methoxytacrine (7-MEOTA) derivatives were synthetized and extensively investigated to find less toxic compounds affecting pathological mechanisms associated with development of AD. There is less known about effects of these drugs on mitochondrial functions and cellular energy metabolism. The aim of this project is to examine in vitro effects of ChE inhibitors on energy metabolism and cellular respiration, specifically on mitochondrial electron transport chain complexes and an enzyme of the citric acid cycle - citrate synthase. Inhibitory effects...
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Effect of cholinesterase inhibitors on monoaminergic system and energic metabolism
Kalinová, Tereza ; Mladěnka, Přemysl (advisor) ; Štěpánková, Šárka (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Tereza Kalinová Supervisor: Assoc. Prof. Přemysl Mladěnka, Pharm.D., Ph.D. Mentor: Assoc. Prof. Jana Hroudová, Pharm.D., Ph.D. Title of diploma thesis: Effect of cholinesterase inhibitors on monoaminergic system and energy metabolism Cholinesterase (ChE) inhibitors play an essential role in the treatment of Alzheimer's disease (AD). They effect positively cognitive, functional and behavior symptoms of AD. Up to date, donepezil, rivastigmine and galantamine represent the only ChE inhibitors approved for AD treatment. The first ChE inhibitor was tacrine, which was withdrawn from market due to its toxicity and adverse effects. Recently, novel tacrine and 7-methoxytacrine (7-MEOTA) derivatives were synthetized and extensively investigated to find less toxic compounds affecting pathological mechanisms associated with development of AD. There is less known about effects of these drugs on mitochondrial functions and cellular energy metabolism. The aim of this project is to examine in vitro effects of ChE inhibitors on energy metabolism and cellular respiration, specifically on mitochondrial electron transport chain complexes and an enzyme of the citric acid cycle - citrate synthase. Inhibitory effects...
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Case study of the Physiotherapeutic Treatment of a Patient Diagnosed with Nervus Peroneus Paresis
Šímová, Lenka ; Reckziegelová, Petra (advisor) ; Štěpánková, Šárka (referee)
Title: Case study of the Physiotherapeutic Treatment of a Patient Diagnosed with Nervus Peroneus Paresis Aims: Acquisiting theoretical and practical knowledge of peripehral paresis, especially the peripheral paresis of nervus petroneus, followed-up by elaborating a casuistry of a patient diagnosed with a selected diagnosis created over the duration of practical training. Methodology: The general part of this bachelor thesis contains theoretical findings about anatomy of the peripheral nervous system, peripheral paresis clinical image, treatment and follow-up therapy. The special part contains a description of selected physioterapeutic methods in practice. Results: Reduction of a degree of shortening of selected muscles, elimination of reflexive mutations of soft tissues, renewal of joint play and strength enhancement of selected weakened muscles. Conclusion: Physiotheraphy is an integral part of peripheral paresis treatment. Key words: physiotherapy, neurology, paresis, peroneus, rehabilitation
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Changes in blood pressure during group remedial exercise in cardiac patients
Štěpánková, Šárka ; Majorová, Simona (referee) ; Daďová, Klára (advisor)
3 Title of the thesis: Changes in blood pressure during group remedial exercise in cardiac patiens Objektive: The aim of this thesis was to describe the changes in blood pressure during remedial exercises. Method: There were 11 females participating in the study, all of senior age and suffering cardiovascular conditions. The exercise unit was intentionally selected to suit treated cardiac patients. The blood pressure readings were taken during the one-hour exercise units at Motol Faculty Hospital. Mercury tonometers were used for the measurements and readings. Results: During the exercise, average systolic blood pressure readings ranged between 137,73 mm Hg and 183 mm Hg, (± SD 28,99) ,diastolic blood pressure ranged between 85,91 mm Hg and 100,45 mm Hg, (± SD 18,88), and pulse rate was between 69 and 77. In four of the tested subjects the systolic blood pressure exceeded 200 mm Hg during the exercise. The highest blood pressure readings were taken when lying down, after a dynamic warm-up, and during lying on the back while moving one leg vigorously. Key words: Blood pressure, cardiovascular disease, remedial exercise, measuring blood pressure.
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