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Design of Modernization of Bohuslavice nad Vláří Railway Station
Štěpán, Jan ; Pur, Kamil (referee) ; Plášek, Otto (advisor)
The focus of the thesis is to design a modernization of the Bohuslavice nad Vláří train station. The reconstruction design includes an adjustment of the station head and the geometrical layout of the track for an increase of the track speed to the highest possible value. The design also contains a renewal of the railway superstructure and the structure of the sleeper subsoil, new drainage and platforms. The designed layout ensures a safe access for people with reduced mobility.
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Design of Optimization of Track Section Bylnice - Vlárský Průsmyk
Štěpán, Jan ; Mráz, Martin (referee) ; Plášek, Otto (advisor)
The focus of the thesis is to design a optimization of the geometrical layout of the track for an increase of the track speed to the highest possible value and a reconstruction of the permanent way superstructure between railway stations Bylnice - Vlárský Průsmyk. The work also includes a design of sleeper subsoil, renewal of the drainage and a design of the construction technology and procedures. Necessary view triangles will be added for unsecured level crossings.
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Vascular Calcification and Bone Demineralization in Patiens with Chronic Renal Failure
Mareš, Jan ; Opatrná, Sylvie (advisor) ; Topolčan, Ondřej (referee) ; Spustová, Viera (referee) ; Štěpán, Jan (referee)
Background: Patients treated with chronic dialysis show extreme mortality, particularly due to cardiovascular disease. Renal failure is associated with different risk factors of cardiovascular complications than those defined for non-renal population. One of these factors, currently considered most important, are vascular calcifications. At the same time, patients on dialysis regularly suffer from derrangements of calcium-phosphate metabolism, including skeletal demineralization. As a consequence, both incidence and prevalence of bone fractures are high. Aims: This study therefore investigates vascular calcifications and skeletal demineralization, their clinical implications and associations in patients treated with long-term dialysis. Methods: Two groups of patients were examined in a prospective manner (follow-up > 1 year); 32 patients treated with peritoneal dialysis and 72 treated with regular hemdodialysis. Treatment parameters and biochemical markers of calcium-phosphate metabolism were monitored throughout the study. Bone mineral density of lumbar spine (together with vertebral fractures) as well as coronary artery, valvular and aortic calcifcations were determined repeatedly. All radiological parameters were measured during one computed-tomography scanning session. Results: A significant...
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Bone remodeling in rheumatic diseases: Bone loss in juvenile idiopathic arthritis
Brábníková Marešová, Kristýna ; Štěpán, Jan (advisor) ; Blahoš, Jaroslav (referee) ; Hrnčíř, Zbyněk (referee)
Introduction: The inflammation plays the essential role in the bone loss in juvenile idiopathic arthritis (JIA). Proinflammatory cytokines and also glucocorticoids (GCs) may activate bone resorption by osteoclasts. Simultaneously, bone formation can be attenuated, especially by inhibitors of proteins, which control the osteoblast differentiation. The aim was to verify the hypothesis that in patients with highly active JIA, reduction of bone formation via Wingless (Wnt) proteins inhibitors - Dickkopf 1 (Dkk-1) and sclerostin could be found. Except the densitometry measurements of bone and lean mass, we assessed markers of disease activity, bone metabolism and remodeling in young adult patients with JIA before and during 2 years of anti TNFα (tumour necrosis factor α) treatment, which decreases disease activity. Results: In patients with JIA before antiTNFα treatment, bone mineral density (BMD, g/cmš) was significantly reduced compared to controls. Values of BMD and body composition in JIA significantly depended on disease duration and GCs treatment. Serum concentration of sclerostin was significantly elevated in JIA compared to values in healthy controls. Values of the other monitored markers did not differ between JIA and controls. In patients with JIA, Dkk-1 correlated positively with C-reactive...
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Changes of landscape structure and scattered greenery in the Jistebnicko region
Štěpán, Jan ; Lipský, Zdeněk (advisor) ; Romportl, Dušan (referee)
The landscape has been profoundly affected by human activity for centuries and the consequences of this interference have been growing in scale with the rising demands of modern society. The processes leading to the landscape's homogeneity, or, on the other hand, its fragmentation, have been focus of many studies which then allow us to understand how the landscape functions in its entirety and are also significant for the process of spatial planning on the local level. The aim of this theses is to assess the changes done to land cover an landscape's (micro)structure with special focus on scattered greenery (non-forest woody vegetation), as well as to examine how these changes have been mapped into the cadastral municipality of Cunkov, located in the Jistebnická vrchovina highlands, throughout the last 180 years. It is then possible to analyze these changes using the GIS and historical materials from three time periods which were beforehand selected - the years 1840, 1953 and 2019. Microstructure of the landscape plays an essential role in landscape's dynamics and for its ecologic stability.
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Hepatitis E infection in hunters from wild cloven-hoofed game animals
Štěpán, Jan ; Kudlová, Jana (advisor) ; Chvojková, Kateřina (referee)
Introduction: In the last ten years there has been a rapid increase of hepatitis E cases (hereinafter as HEV) in the Czech Republic and European Union. In accordance with findings from recent years the prevalence of this infection in boars, deer, roe deer, fallow deer and other cloven-hoofed game has risen too. Under Czech law these animals can be hunted by hunters who are the first ones to come into contact with the hunted animals in the greatest extent which entails the highest risk of infection. This Diploma Thesis deals with viral hepatitis E as an acute zoonotic virus transmissible from wild cloven-hoofed animals to hunters. The author sought to determine the level of awareness of the hunting society of the risks of infection, their awareness of this infection and protection against it to improve possible protection. The theoretic part of the Diploma Thesis deals with, including, but not limited to, basic information about viral hepatitis. Materials used to prepare the theoretic findings of this Diploma Thesis were obtained from a research made by the National Medical Library, from sources found in expert databases (ResearchGate, ScienceDirect, Scopus, PubMed, Web of Science, Google Schollar and others), from the opinions of professional organisations and associations about HEV and their...
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Návrh dvougeneračního rodinného domu
Štěpán, Jan
This diploma thesis deals with design of house for living of two generations. The house is designed with the form of wooden frame structure with the extensive green roof system. In the first part, the thesis is focused to issues of energy efficiency and passive house standard of living. In the next part is described topic of the green roof. In the practical part is described selection of structural system, design of composition structures including requirement for implementation of construction works. Furthermore is performed thermal technical assessment of composition structures and calculation of energy balance according to PHPP. In the end is a brief description of static design of ceiling structure. The drawing part includes project and manufacturing documentation including solutions of important construction details.
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Bone remodeling in rheumatic diseases: Bone loss in juvenile idiopathic arthritis
Brábníková Marešová, Kristýna ; Štěpán, Jan (advisor) ; Blahoš, Jaroslav (referee) ; Hrnčíř, Zbyněk (referee)
Introduction: The inflammation plays the essential role in the bone loss in juvenile idiopathic arthritis (JIA). Proinflammatory cytokines and also glucocorticoids (GCs) may activate bone resorption by osteoclasts. Simultaneously, bone formation can be attenuated, especially by inhibitors of proteins, which control the osteoblast differentiation. The aim was to verify the hypothesis that in patients with highly active JIA, reduction of bone formation via Wingless (Wnt) proteins inhibitors - Dickkopf 1 (Dkk-1) and sclerostin could be found. Except the densitometry measurements of bone and lean mass, we assessed markers of disease activity, bone metabolism and remodeling in young adult patients with JIA before and during 2 years of anti TNFα (tumour necrosis factor α) treatment, which decreases disease activity. Results: In patients with JIA before antiTNFα treatment, bone mineral density (BMD, g/cmš) was significantly reduced compared to controls. Values of BMD and body composition in JIA significantly depended on disease duration and GCs treatment. Serum concentration of sclerostin was significantly elevated in JIA compared to values in healthy controls. Values of the other monitored markers did not differ between JIA and controls. In patients with JIA, Dkk-1 correlated positively with C-reactive...
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