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Prognostic importance of angiopoietin-2 gene transcription in chronic lymphocytic leukemia.
Gradošová, Iveta ; Pecka, Miroslav (advisor) ; Smolej, Lukáš (referee)
Chronic lymphocytic leukemia (CCL) is the most common leukemia, which is characterised by a high variable progress. According to scientific evidence acquired during several last years, angiogenesis has been proven to play an important role in pathogenesis of CLL. One of the very important cytokines playing role in this process is angiopoietin-2 (Ang-2). Elevated expression of Ang-2 has been reported in several hematological malignancies; however, data regarding Ang-2 in CLL are very limited. I measured Ang-2 transcript levels in purified mononuclear cels of 24 untreated patients with CLL by quantitative real-time PCR and normalized them for differences in RNA concentration in each sample by quantitation of transcript of Abl1 housekeeping gene. Elevated Ang-2 mRNA concentrations were detected in 10 cases (Ang-2 to Abl1 expression ratio > 5x10-3). On the other hand, 14 patients had very low or undetectable levels of Ang-2 mRNA (Ang-2 to Abl1 expression ratio < 5x10-3 or Ang-2 Cp > 35). The association between Ang-2 expression and other prognostic factors, clinical stage according to Rai and clinical course of CLL was evaluated by Chi-Square method. There was a significant association between high Ang-2 mRNA levels and unmutated IgVH genes (n= 21, p = 0.012), but not with CD38 (p = 0.057), ZAP-70 expression (p...
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Perception-cognitive skills of football assistant referees
Suchý, Václav ; Psotta, Rudolf (advisor) ; Zahálka, František (referee) ; Buzek, Mario (referee)
Název: Percepčně kognitivní dovednosti asistentů fotbalových rozhodčích Název v angličtině: Perceptual and cognitive skills of football assistant referees: Systematical review Cíl práce: Metoda: Výsledky: Poukázat na současné poznatky o percepčně kognitivním výkonu asistentů fotbalových rozhodčích při posuzování vzájemných pozic hráčů ve vztahu k pravidlu o ofsajdu. Získávání informací z odborných publikací, databází, vědeckých časopisů a dostupných internetových publikací. Na jejich základě vytvoření systematického přehledu dosavadních poznatků. Práce vymezuJe základní problematické okruhy v posuzování ofsajdových situací, kterými jsou určování vzájemných pozic hráčů, přesouvání zorného pole asistentů rozhodčích a jejich postavení. Dále potvrzuje hypotézu efektu opožděného záblesku a hypotézu efektu optické chyby jako hlavní příčiny chybování asistentů fotbalových rozhodčích při posuzování ofsajdových Klíčová slova: situací. Ukazuje na možnosti redukce těchto chyb a alternativní způsoby posuzování ofsajdových situací. Asistent rozhodčího, ofsajd, efekt opožděného záblesku, efekt optické chyby, percepční a kognitivní dovednost.
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Bone metastases
MELICHAROVÁ, Miroslava
This bachelor's thesis deals with the topic ?Bone metastases?. The topic is split into the theoretical and practical part. To understand better the whole topic, I describe in the theoretical part at first the general anatomy of the bone tissue, subsequently the structure and growth of bones. There are described individual types of bone shapes. Also the process of occurring metastases or primary tumors in surrounding tissue is described, way of spreading and growth of tumor cells in the bone tissue is specified. Moreover I specify the occurrence of bone metastases and their diagnostics. In the diagnostics we notice at first the clinical symptoms bringing the patient to the physician. Three targets were determined for this thesis. The first target was to find out the most frequent places of occurrence of bone metastases. The second target was to find out the most frequent diagnostic method. And the third goal was to find out the most frequently used type of treatment during the occurrence of bone metastases. Also research questions were postulated. Research question No. 1: Do the bone metastases occur most frequently in the parts of red bone marrow with a rich blood circulation? Research question 2: Are the bone metastases diagnosed more frequently at women? To acquire the results, the databases of patients of the hospital České Budějovice a.s. and the hospital Na Homolce in Prague, radio-diagnostics, radiotherapy wards and ward of nuclear medicine were used. In the radio-diagnostic ward in České Budějovice and in Prague it was necessary to go through the records of all the diagnosed patients who underwent X-ray, CT and MR examination in the years 2011, 2012 and the subsequent records of data of patients with described (by physicians) occurrence of meta-static process in skeleton. There are among the necessary recorded data: age, sex, primary diagnosis, location of bone metastases and the applied examination method. In the practical part of the bachelor's thesis, these data were processed in diagrams and subsequently answers to set targets and research questions were formulated. In the radio-therapeutic wards the records of patients with indication of palliative radiation for the year 2011, 2012 were checked and in case of finding a patient radiated by palliative method due to occurrence of bone metastases the information concerning the age, sex, primary diagnosis, location of bone metastases and the applied radiation method (targeted or half-body radiation) were recorded. The acquired information was processed into diagrams in the practical part of bachelor's thesis again. Unfortunately, from the department of nuclear medicine no information about the amount of performed bone scintigraphy for metastatic process in skeleton were acquired, only information about patients treated by radio-nuclides. The answer to the research questions 1, ?whether the most frequent place of bone metastases is the part of red bone marrow with a rich blood circulation? was given already in the information about the most frequent location of bone metastases, as in the adult age, the red bone marrow occurs most frequently in the vertebra bodies, pelvis bones, breast bone, rips, flat bone of scull and long bones, where the red bone marrow occurs in the joint ends and based on my research, the metastases were located most frequently in these places. The answer to the research question 2: ?Are the bone metastases diagnosed at women more frequently?? It followed from my research that more bone metastases were diagnosed at men. Also the information leaflet for lay public was elaborated to my bachelor thesis informing of symptoms, diagnostic methods and treatment of metastatic process in bones.
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Designing mass modification of client contact records and theirs consolidation within financial institution
Převrátil, Martin ; Kunstová, Renáta (advisor) ; Jeřábek, František (referee)
This master thesis deals with management request towards informatics department within front company that provides wide range of financial services. Demand refers to client contact data, particularly correspondence addresses and calls for possibility to mass change such records. There are several relatively separated tasks which need to be discussed in order to fulfill the request. First part introduces the company and analyze current situation. Then continue by describing correspondence addresses issue and supports with reasons for the inevitable change. Company's information system architecture is outlined with emphasis on central database that is being formed. This part also further describes options how data can be stored. Middle part contains reason--based choice where correspondence records should be maintained in company's data architecture. Implementation plan with chosen storage pattern is formed here and connected changes in system are highlighted. As a last processes connected to correspondence addresses mass modification are described and drawn with selected notation. After that user graphic interface is designed as a place where the self request will be served.
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Possibilities of using Caché database system
Brož, Ondřej ; Palovská, Helena (advisor) ; Vedral, Pavel (referee)
Structure of this work is divided into a few main chapters. The biggest part is focused on a creation relational and object schema of a specific example and their realization in Caché database. The next goals are theoretically describe database, object model, its characteristics as well and comparison the object principles in Caché and Oracle database. After a few words whose describe the most important facts in a history of databases the reader can learn something about the Caché database. Mainly its architecture which is the greatest advantage against the competition. Next charter quickly show how to successfully install and access the database. In charter 4 the basic database tools are mentioned such as development environment Caché Studio, command line Caché Terminal and web interface for administration called Caché System Management Portal. The fifth and sixth chapter covers the main goal of this work. In fifth chapter the object model (relational model only in part), its basic principles (defined in ODMG standards) and object characteristics are described. The sixth chapter show the creation process of the object schema "step by step" together with possible ways how to insert data and select them. Final codes for structure and data are placed at the end of work . In last chapter I am trying to compare object characteristics in Caché and Oracle database(version 10gR2). The contribution of this work is in explanation of object principles with the "step by step" processes of creating and realization object schema shown on a concrete example (the official documentation doesn't obtain them).
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The Onset of Normalisation in the Czechoslovak Television
Slunečková, Karin ; Štoll, Martin (advisor) ; Bednařík, Petr (referee)
This thesis tackles the onset of normalisation in Czechoslovak Television between 1969-1975. Firstly the author introduces the reader to the subject through the historical context. Above all, the thesis focuses on dramatic changes that affected Czechoslovak Television in that era. Further, the thesis is dedicated to one of main players and representatives of normalisation in Czechoslovak media, general director of Czechoslovak Television Jan Zelenka, who remained in office between years 1969 and 1989. The author uses not only published sources, but also internal documents and databases of Czechoslovak Television and documents from the National Archive. In the analytical part of the thesis the author describes the function and structure of Ideological Thematic Plans which served as a foundation document for the TV broadcasting for one year to the next. Using the Ideological Thematic Plan of 1973 the author analyses their content. The author carries out an in-depth analysis of three TV programmes chosen from the Ideological Thematic Plan of 1973. These programmes represent three different genres - a broadcast targeting the young Through Young Eyes (Mladýma očima), a television series of nine episodes Mother (Matka), and a feature film, And Give My Love to the Swallows (…a pozdravuj vlaštovky)....
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Development of probabilistic SBRA method and integrated design of structures
Marek, Pavel
The computer revolution allows for considering transition from deterministic and prescriptive structural reliability assessment methods to probabilistic concepts using simulation technique, non-parametric variables, non-traditional criteria and more. The subject of the paper is a draft of Roadmap of the development from current codes to Integrated Design (Performance Based Design, Life Cycle Assessment, Risk Engineering and Monitoring). The attention is given to probabilistic, design (dimensioning) and to the assessment strategy using Simulation-Based Reliability Assessment approach (SBRA) corresponding to the computer era.
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Hranové efekty v rotační viskozimetrii IV. ZZ (Couette) senzory, bez skluzu, skutečná viskozitní funkce.
Wein, Ondřej
Neglect of end effects in Couette rotational viscometry introduces 10-30% error in the estimate of shear stress at spindle surface. Actual deviations depend on the shear-thinning level of a given sample. We tackle the end effect for the standard sensor Z40 DIN according to ISO 3219 by solving the related 2D boundary-value problem for a class of shear-thinning viscosity functions. Pseudosimilarity method of treating the primary data leaves an error in shear stresses about 0.5%. Further reduction of the errors needs a full numerical simulation for each point of primary data, based on a suitable wide-range representation of the viscosity function. To support high accuracy of torque calibrations, the effect of inertia on torque for Newtonian liquids in standard sensor Z40 DIN at Re < 500 is calculated using the FLUENT 6.2 commercial software.
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