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Computer modelling of origin of arrhythmias in myocardial cell
Brožková, K. ; Pásek, Michal
This contribution presents the effect of changes of membrane channel conductivity on the origin of arrhythmias in cardiac cells. The simulations were performed for stimulation frequency 2Hz and compared with results for stimulation frequency 1Hz. It was confirmed that the increase of conductivity of ICa-channels and decrease of conductivity of IK1, INaCa and INaK channels induce single cell arrhythmias.
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Implementation of the Smart Metering Systems in Energetics in Slovakia
Petreová, Adela ; Machek, Ondřej (advisor) ; Tyll, Ladislav (referee)
The goal of the Master´s thesis is to map the actual situation of transformation of power energy sector to smart grid, find answers to some of the major questions concerning the implementation of smart metering systems, evaluate societal and economic costs and benefits, evaluate trends in legislation, compare the situation in Slovakia with other peer countries from the European Union, and create a follow-up recommendations for Slovakia based on this assessment. The thesis includes detailed critical analysis of the CBA, originally created for Slovakia, using benchmarking with countries with a different calculation approach. The used methodology in this work is a research of available resources, qualitative research of case studies, break-down of the CBA, and expert research through interviewing. The outcome is evaluation of economic and societal contributions of smart metering systems and mapping the process and state of the implementation.
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Řízení IS/ICT se zaměřením na sourcing služeb informačního systému
Šebesta, Michal ; Voříšek, Jiří (advisor) ; Havlíček, Zdeněk (referee) ; Příklenk, Oldřich (referee) ; Král, Jaroslav (referee)
Research on outsourcing has been around for several decades, while recent evolution in the information systems discipline towards ICT service commoditization significantly changes the context of decision-making. Services that are available on-demand via the Internet allow organizations implementing functions they demand in a fraction of time. This trend represents a chance for organizations seeking to use advanced ICT services without a need of major investments. Problem is the current lack of guidelines and tools for managing ICT services and their outsourcing. Given the trends on the ICT service market, it is expected that much of the IT management in the future will encompass the ICT services and utilize service-level structures. Methods currently available are either too broad or encompass only small part of the whole problem. Ad-hoc or unsound decisions in this area might cause major complications in terms of quality, usability, integration, and consequently influence total cost of organizational IT. Organizations need to either revise existing models or propose and implement completely new models to manage their IS/ICT. This thesis deals with the management of IS/ICT with focus on the ICT services outsourcing. It discusses available sourcing models in the literature and links them to the various interconnected areas. Based on these areas, it presents an integrated view on IT outsourcing strategies. Most importantly the thesis proposes an original concept for decision-making about outsourcing of ICT services named the SOURCER framework. This approach utilizes the presented outsourcing strategies, and introduces a complex methodology and decision-making criteria that will assist organizations with selection of ICT services in order to maintain and manage a most suitable ICT service portfolio. The decision-making is based on four essential viewpoints: function, costs, time, and quality. These viewpoints are discussed, individually analyzed, and serve as a basis for further research. The whole framework is developed and validated according to Design Science Research Methodology (DSRM). Individual components are evaluated using a survey among a group of selected IT managers. Proof of concept is then established by a case study on framework use in a real organization. This case study covers strategy specification, business--IT alignment, specifying service architecture and its interconnections, outsourcing, and management of the ICT service portfolio.
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Clustering and regression analysis of micro panel data
Sobíšek, Lukáš ; Pecáková, Iva (advisor) ; Komárek, Arnošt (referee) ; Brabec, Marek (referee)
The main purpose of panel studies is to analyze changes in values of studied variables over time. In micro panel research, a large number of elements are periodically observed within the relatively short time period of just a few years. Moreover, the number of repeated measurements is small. This dissertation deals with contemporary approaches to the regression and the clustering analysis of micro panel data. One of the approaches to the micro panel analysis is to use multivariate statistical models originally designed for crosssectional data and modify them in order to take into account the within-subject correlation. The thesis summarizes available tools for the regression analysis of micro panel data. The known and currently used linear mixed effects models for a normally distributed dependent variable are recapitulated. Besides that, new approaches for analysis of a response variable with other than normal distribution are presented. These approaches include the generalized marginal linear model, the generalized linear mixed effects model and the Bayesian modelling approach. In addition to describing the aforementioned models, the paper also includes a brief overview of their implementation in the R software. The difficulty with the regression models adjusted for micro panel data is the ambiguity of their parameters estimation. This thesis proposes a way to improve the estimations through the cluster analysis. For this reason, the thesis also contains a description of methods of the cluster analysis of micro panel data. Because supply of the methods is limited, the main goal of this paper is to devise its own two-step approach for clustering micro panel data. In the first step, the panel data are transformed into a static form using a set of proposed characteristics of dynamics. These characteristics represent different features of time course of the observed variables. In the second step, the elements are clustered by conventional spatial clustering techniques (agglomerative clustering and the C-means partitioning). The clustering is based on a dissimilarity matrix of the values of clustering variables calculated in the first step. Another goal of this paper is to find out whether the suggested procedure leads to an improvement in quality of the regression models for this type of data. By means of a simulation study, the procedure drafted herein is compared to the procedure applied in the kml package of the R software, as well as to the clustering characteristics proposed by Urso (2004). The simulation study demonstrated better results of the proposed combination of clustering variables as compared to the other combinations currently used. A corresponding script written in the R-language represents another benefit of this paper. It is available on the attached CD and it can be used for analyses of readers own micro panel data.
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Assessment of devices used by the Armed Forces of the Czech Republic in case of radiation emergency.
LOŠKOVÁ, Romana
This Thesis deals with the option of employing the Armed Forces of the Czech Republic (ACR) when a radiation emergency is imminent. Primarily, it focuses on evaluation of selected devices designed for radiation reconnaissance; summarising of radiation protection related legislation; and study of approved procedures. At its beginning, this Thesis tracks the origin of early detection systems at the territory of the then Czechoslovak Socialist Republic and their gradual evolution into the the existing form. From the radiation emergency point of view, this nationwide system represents a priceless help for monitoring of radioactive contamination dispersion and for warning. The following part sums up basic information on what is an ionizing radiation, how it comes into being and which basic quantities describe it. This part also contains basic type distinction, description of consequences for human organism and the most significant interactions of sources of ionizing radiation that could be misused with the most probability. This specific topic is introduced here because of the subsequent part of this Thesis being named Radiological Dispersion Device, or the dirty bomb. The significant part of this Thesis is the summary and classification of related legislation. The first documents referred to are two international standards. Publication 103 the 2007 Recommendations of the International Commission on Radiological Protection is dealing, inter alia, with dosing limits determining dose levels in planned exposure situations and reference levels used for emergency exposure situations and existing exposure situations. Publication 96 Protecting People against Radiation Exposure in the Event of a Radiological Attack is more substantial for this Thesis since it partly copes with the protection of front-line units including Integrated Rescue System (IRS) components and it specifies maximum exposure time for intervening personnel. Based on the IRS Catalogue of Typical Activities (STC 01/IZS), Materialised and Verified Use of a Radiological Weapon, the ACR would be one of the intervening components in such an attack. This Thesis analyses in detail individual ACR procedures starting with activities before employment, through threat prevention, event reaction to post-event activities like decontamination followed by monitoring of personnel contamination and their health condition. The practical part deals mainly with one of the Thesis´s goals which was evaluation of selected dosimetric devices used by the military for radiation reconnaissance. For this purpose, the quantitative research processing their main parameters was applied. The analysis within a selected sample was used for comparing and the sumary index IVi then showed the status of device applicability for contemporary use in radiation emergency. The pre-defined goals of this Thesis have been met implementing the above methods. The comparison of individual devices and their evaluation in respect to their applicability in joint radiation emergency operation with other IRS components has been carried out via discussion. It has been found out that some of the devices are obsolete and do not comply with the requirements for this job. This fact reflects the reality that these devices were designed in the period of a potential nuclear war. This corresponds with their robust structure and high level of sensitivity which is not desirable for a radiation emergency. The most severe problem, however, seems to be the fact that some devices measure quantities in old, no more used, units which could cause misinterpretation. On the other hand, other devices are modern, sensitive at low levels of dose input and offer real-time information on a well organised LCD display. To answer the question of ACR´s readiness to intervene in a radiation emergency one has to say that the ACR is ready to meet its rescue and consequence management tasks at a satisfactory level.
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Process Analysis As the Basis for the Implementation of a New Information System
Kmochova, Zdena ; Říhová, Zora (advisor) ; Svatá, Vlasta (referee)
The main objective of this thesis is to analyze the processes in the company POP service, Ltd., also to analyze the current problem in this company and to recommend and propose measures which eliminate the causes of the emergence of the problem. The causes originate from the aspects of the management of people and processes are identified through the analysis of processes associated with the problem and eliminated on the basis of proposals metrics and responsibilities for these processes. The theoretical part of the thesis is devoted to concepts in the field of process management. The theoretical part characterizes these concepts process management, business processes, process analysis and process modeling methods, process maps, graphical notation for writing business processes, business process improvement and analysis organization. In the second part of the thesis is presented the examined organizations POP service, Ltd.. Based on the analysis of the current state are defined vision, mission and goals of the organization. Then there is described a procedure of the analysis of the current state, which is process analysis and proposal of selected processes, metrics and responsibilities for these processes. Methods of analysis are SWOT analysis, analysis of the activities, structured interviews and process analysis. The result of this thesis is to analyze the selection of processes of the company POP service, Ltd., proposal metrics, define jobs and responsibilities and suggestions for improving the selected process.
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Position of Czech Documentary Photography During the Normalization Era
Folk, Čeněk ; VANČÁT, Pavel (advisor) ; Ledvina, Josef (referee)
The subject of my thesis is the position of Czech documentary photography during the normalization era in Czech territory. The term "position" encompasses several aspects of review: political and creative conditions under which the Czech documentary photography was originating; its status within the photography as artistic discipline and within other artistic disciplines; thinking about documentary photography and its changes over time; social application of documentary photography and its impact on society and, last but not least, its impact on political events. In the 70s and 80s the Czech documentary photography reached the greatest expansion, despite the uneasy political background. My thesis examines (among other things) how, why and under what circumstances this boom occurred.
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Scream and Silence
Štefaňák, Ondřej ; NEBESKÝ, Jan (advisor) ; KORČÁK, Jakub (referee)
The work aims to examine the artistic expressionist tendency, manifested in expressionist drama and theater practice. In the first part, the author focuses on the origin and the direction of its general manifestations in arts and the historical context of expressionism. The author also attempts to highlight the features of expressionism in drama and contemplates the methods of expressionist artists in theater. In the second part, the author reflects his own experience of the production of an early expressionist text ''Spring’s Awakening''. He analyzes the text's dramaturgical potential and creates the basis for the theatrical production. He describes the creation of the staging as an audio-visual and scenic solution, where the particular focus is on the stylization of actors. Finally, the author tries to capture the essence of expressionism in a broader sense, as a peculiar way of expression for the artist.
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The journey of polka to the opera The Bartered Bride
Adams, Tereza ; FRIČOVÁ, Marie (advisor) ; GREMLICOVÁ, Dorota (referee)
This diploma thesis contains the description of the polka dance, its origin and short history. The next part belongs to the opera of Bedřich Smetana „The Bartered Bride“ from its creation through to the next presentations in the National theatre in Prague until the actual performance. In the last part there are descriptions of three chosen choreographies of polka from this opera and their analysis according to the model of Janet Adshead – Lansdale. Supplements contain biographies of Bedřich Smetana and choreographers of chosen inscenations – Otto Šanda, Pavel Šmok and Ladislava Košíková.
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Microbiota of the digestive tract of bees and related insect and the influencing facftors
Hroncová, Zuzana ; Havlík, Jaroslav (advisor) ; Kalous, Lukáš (referee)
This thesis consists of six research chapters, out of which, five have already been published in research journals, 1 is in the process of submission and the last chapter presents original unpublished confidential data in the process of manuscript preparation.
The research presented in this thesis concerns the complex mechanisms of bees and wasps immune system focused on microbiota as component of immunity. As shown in the introduction, highly social and managed species of bees like honey bees and bumble bees, play key roles in natural and agricultural ecosystems worldwide. Recent losses of bees have been attributed to pesticide exposure, poor nutrition, increased parasite loads and habitat degradation. Over the past several years, governments, beekeepers, and the general public worldwide have become concerned by increased losses of honey bee colonies, calling for more research on how to keep colonies healthy. Our main aim was to explore the complex mechanisms of bees and related species gut bacterial populations, their links to insect immunity and investigate the opportunities for an intervention. Part of our aim was to characterise the bumble bee and wasp gut microbiota using 16S RNA sequencing in a search for potentially novel bacterial species.
We have tried to explain how microbiome interacts with the host and showed that major members of these communities appear to benefit the host. The simple gut communities of social bees present ideal model systems to investigate the underlying evolutionary and genetic processes of such interactions. Information based on our results may help in the design of proper probiotic supplementation strategies with respect to physiological conditions in the honey bee gut.
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