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Role of Exosomes in the Progression, Diagnosis, and Treatment of Brain Tumors
Vaníková, Lucie ; Zíková, Martina (advisor) ; Lacina, Lukáš (referee)
Recent studies have confirmed the importance of extracellular vesicles, particularly exosomes, in the development of brain tumors. Considerable attention has been paid mainly to the influence of exosomes on biological processes in brain tumors. Exosomes mediate intercellular communication in the tumor microenvironment by transporting biomolecules. Most often they transmit various types of ribonucleic acids, specifically microRNAs, which affect the signalling pathways related to tumour growth in target cells. Thus, exosomes play an important role in tumor cell proliferation and differentiation, metastasis, and tumor resistance to chemotherapy or radiation. Due to their small size, exosomes can cross the blood-brain barrier and thus promote tumor progression. The topic of the bachelor thesis is a summary of the current knowledge on the role of exosomes in brain tumor progression, diagnosis and treatment.
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The use of PEDI-CAT in occupational therapy in children patients with medulloblastoma. Subtitle: Pediatric Evaluation of Disability Inventory - Computer Adaptive Test
Havejová, Gabriela ; Krulová, Anna (advisor) ; Angerová, Yvona (referee)
The aim of this master thesis is to elaborate the issue of the PEDI-CAT test and to evaluate its contribution in the proces of occupational therapy in patients with medulloblastoma. The theoretical part deals with the test itself, its origin, process of standardization and comparison with the older version of the test. The theoretical part further informs about the possibility of using the test in different areas and in different diagnoses. The last part of the theory analyzes the area of occupational therapy in pediatric patients with diagnosis of medulloblastoma. The practical part contains three case reports of pediatric patients diagnosed with medulloblastoma, which make it described the benefits of practical use of the PEDI-CAT test in occupational therapy in this diagnosis. In the appendices of the thesis is a brief guide to the test, translated by the author of the thesis, which can serve as a guide to facilitate the work with the test, for those who will take the test in practice. The contribution of this thesis is to introduce the PEDI-CAT to the professional public in the Czech Republic. Putting the PEDI-CAT into practice will help facilitate testing and evaluating the outcome of occupational therapy in pediatric patients. Furthermore, the contribution of this thesis is to evaluate the...
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