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Controlled laboratory supply
Štibraný, Miroslav ; Petyovský, Petr (referee) ; Macho, Tomáš (advisor)
Master’s thesis deals with design of laboratory supply with precise voltage and current measuring. At the beginning it presents properties, advantages and disadvantages of linear and switching supplies, based on these facts it chooses a linear type of regulator. The design continues with detailed description of power and control analog and digital circuits. The thesis includes description of taking control over the supply from the front panel or through computer. The last part is devoted to measurement results and to presentation of some static and dynamic parameters of the designed supply.
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Alzheimer's disease-related changes in phosphorylation of collapsin response mediator protein 2 (CRMP2) and their effect on neuronal function
Škrlantová, Alice ; Balaštík, Martin (advisor) ; Balík, Aleš (referee)
CRMP2 was first identified in 1995 as a mediator of Sema3A signalization pathway which leads to axon growth cone collapse. Since then CRMP2 was designated as an essential cue during neuronal polarity estabilishment and neuronal growth in embryonic life. CRMP2 was also found hyperphosphorylated in NFT's and this finding led to further research of CRMP2 function in the pathogenesis of AD. The activity and proper function of CRMP2 is regulated by phosphorylation and a deeper look into the mechanism of this modification is necessary for understanding how CRMP2 influences the function of neural cells. In this thesis I focus on signaling pathways, kinases and interaction partners of CRMP2 and describe how aberrant regulation of these interactions leads to Alzheimerʼs disease development.
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Mamabloggers and fans raction on their cooperation with companies
Baltaretu, Iva ; Vochocová, Lenka (advisor) ; Švelch, Jaroslav (referee)
In this diploma thesis I deal with the topic of blogs. My main goal was to introduce the part of blogs called mommyblogs and to define it as a separate category in the theoretical background chapter. In the practical part, I decided to use quantitative methods of data collection through a questionnaire survey. The survey was aimed at both mommy bloggers and their readers. I supplemented the questionnaires with depth interviews with selected mommy bloggers. Which helped me to obtain even more detailed data, which enriched the data obtained from both questionnaires. I found out what motivates mommy bloggers to blog, but also what their attitude is towards cooperation with companies and how they select and label collaborations. Have they ever felt exploited either by companies or by social media? The respondents also touched on the topic of ethics and responsibility - either regarding the placement of photos of children on social media or regarding products whose promotion is bound by regulations. I tried to find out the ability of the readers to recognize advertisements on blogs and social networks of mommy bloggers. And also how the advertising message of mommy bloggers affects their readers. This thesis focuses only on bloggers from the Czech Republic.
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What is the Strategic Impact of Chinese Anti-Access and Area-Denial Capabilities on the Offence-Defence Balance in East Asia? A Comparative Case Study of the United States and Japan
Oldemeier, Niels ; Kučera, Tomáš (advisor) ; Urbancová, Kateřina (referee)
iv ABSTRACT Over the last four decades, the People's Republic of China has modernized its armed forces and acquired the world's largest and most diverse missile arsenal. In light of Beijing's vague yet increasingly assertive stance in the region, China's A2/AD capabilities have sparked a discussion about their offensive potential and threat to the region's stability. This thesis has conducted a qualitative strategic impact of Chinese anti-access and area-denial capabilities on the offence-defence balance in East Asia. Applying Biddle's revised offence-defence theory, this thesis investigated and compared the Sino-American and Sino-Japanese balances. The analyses found that Chinese A2/AD capabilities do not have a uniform impact on the offence-defence balance in the region. Despite its offensive potential, Chinese A2/AD does not provide an effective, sustainable counter to Japan's deep, reserve-oriented force employment strategy. Even though China fields the world's largest fleet, it does not field enough principal surface ships to exploit a temporary offensive advantage. As such, any Chinese attempt to claim the Senkakus would result in a Chinese naval overstretch and create a mutually contested no man's land in the East China Sea. As for the Sino- American balance, Chinese A2/AD creates an...
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Deep Learning for MRI data
Karella, Tomáš ; Pilát, Martin (advisor) ; Blažek, Jan (referee)
The aim of the thesis is the classification of magnetic resonance images by Deep Learning models. The goal was to predict Alzheimer's disease on the dataset created by Alzheimer's Disease Neuroimaging Initiative (ADNI). To prepare the dataset, we built two processing pipelines, which align, normalise and remove irrelevant features from brain scans. We used the processed scans for a 2D and 3D dataset. We designed a few models based on convolutional and previously proposed architectures. Although, many studies published astonishing results on ADNI classification, the results of our experiments do not support previous research in this area. Contrary to what was previously thought, we found that the accuracy strongly depends on the dataset splitting. If we split the dataset by patients, not by scans, the accuracy drops significantly. We presented an overview of several previously published architectures and our experiments showing results of these architectures on the datasets generated by random splitting or subject-based splitting. We also pointed out how the dataset splitting choice changes the performance of our models. The work is a natural extension of study [Fung et al., 2019]. 1
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Role of interneurons and neural circuit dysfunctions in Alzheimer's disease
Rakovets, Yuliia ; Stuchlík, Aleš (advisor) ; Červená, Kateřina (referee)
Alzheimer's disease is one of the most common neurodegenerative disorder that results in altered network activity, in particular cognitive decline. Majority people with AD experience memory impairment, poor judgment, disorientation and learning difficulties. Several hypotheses try to explain the cause of the disease, but it's poorly understood. Due to the fact that changes in brain structure arise years before clinical symptoms emerge, the available therapeutic treatments can only reduce the impact of neurodegeneration, but not to reverse. Interneurons, as a part of neural circuits, play an important role in the formation of cognitive abilities. Most of interneurons in CNS are inhibitory and they effectively control the network synchrony. Network hypersynchrony is an increased synchronization of neural activity and it's linked to AD pathology. Dysfunction of interneurons is resulted in altered network activity in patients with AD. Keywords: AD, brain, rat, interneurons, hypersynchrony.
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Alzheimer's disease-related changes in phosphorylation of collapsin response mediator protein 2 (CRMP2) and their effect on neuronal function
Škrlantová, Alice ; Balaštík, Martin (advisor) ; Balík, Aleš (referee)
CRMP2 was first identified in 1995 as a mediator of Sema3A signalization pathway which leads to axon growth cone collapse. Since then CRMP2 was designated as an essential cue during neuronal polarity estabilishment and neuronal growth in embryonic life. CRMP2 was also found hyperphosphorylated in NFT's and this finding led to further research of CRMP2 function in the pathogenesis of AD. The activity and proper function of CRMP2 is regulated by phosphorylation and a deeper look into the mechanism of this modification is necessary for understanding how CRMP2 influences the function of neural cells. In this thesis I focus on signaling pathways, kinases and interaction partners of CRMP2 and describe how aberrant regulation of these interactions leads to Alzheimerʼs disease development.
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Animal models of sporadic form of Alzheimer's disease
Popelíková, Anna ; Stuchlík, Aleš (advisor) ; Telenský, Petr (referee)
Alzheimer's disease is a severe illness affecting the elderly and its incidence increases markedly every year. To date, there is no effective treatment for this condition available, and the precise mechanism of the pathogenesis remains elusive (apart from the identification of certain genetic mutations as causes in a small percentage of cases). Also, no suitable animal model of this disease has been found so far. This paper provides a summary of non-transgenic models currently in use as well as newly introduced adepts, their characteristics and examples of their use in practice. It covers both rodent models mostly generated by external interventions to the brain tissue homeostasis of the experimental animals, and vertebrate species that have been reported to spontaneously develop Alzheimer's disease-like pathology: the so-called 'natural models'. Thus, this review might provide better orientation in the up-to-date progress of research of this disease.
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Meaning of lion representation in the past and present - semiotic analysis
Řezáčová, Veronika ; Šafaříková, Radana (advisor) ; Svoboda, Aleš (referee)
In my diploma thesis I deal with symbolism of the representation of lion in current marketing. My thesis follows the conviction that animals have been playing the important role since the beginning of human history. On the grounds of this persuasion I suppose that the animal symbolism is very easy to decode for people because of their previous experience. In the first instance I define the relationship between semiotics and marketing in my thesis. After mentioning several types of prior texts I maintain the position that the image of lion and its symbolism are identically perceived on the basis of and according with the symbolism of lion in those prior texts in current marketing as well. During the studying of the "lion" symbolism I use the terminology of some important authors and theoreticians of semiotics - particularly Roland Barthes's levels of denotation and connotation and distinction of a sign to icon, index and symbol according to Charles Sanders Peirce's theory. I also employ the theory of visual rhetorical figures. I end my thesis with a simple questionnaire which is supposed to complete and confirm my assumptions of the comprehension of the image of lion in marketing - hence the lion usually appears as a patriotic symbol, secondly as a protector, thirdly as a strong and fighting animal.
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