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Multicomponent Analysis
Kovářová, Lucie ; Kubíček, Vladimír (advisor) ; Drastík, Martin (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Candidate: Lucie Kovářová Supervisor: Ing. Vladimír Kubíček, CSc. Title of Diploma Thesis: Multicomponent analysis This diploma thesis deals with the determination of concentrations of individual dyes in mixtures by multicomponent spectrophotometric analysis. The method was tested on selected dyes which were divided into two groups. The first group contains methyl orange, methyl red, orange II and phenol red. The second group consists of methylene blue, bromocresol green and thymol blue. Within each group mixtures were prepared containing combinations of two, three and four dyes in various ratio. Spectra of prepared mixtures were measured by diode array UV/VIS spectrophotometer. Absorbance values were read at wavelengths of absorption maxima of the individual dyes. Using the pseudoinverse matrix, concentration ratios of components were calculated from the absorbance values. The determination in determined and over determined systems was performed. On the basis of the results obtained by the method of analysis it is possible to determine the individual concentration of the multi-component dyes mixtures without prior separation. Keywords: spectrophotometry, multicomponent analysis,...
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Determination of Lipophilicity of Drugs by HPLC
Pleváková, Magdaléna ; Kubíček, Vladimír (advisor) ; Nováková, Veronika (referee)
3 ABSTRACT Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of biophysics and physical chemistry Author: Magdaléna Pleváková Supervisor: Ing. Vladimír Kubíček, CSc. Thesis title: Determination of Lipophilicity of Drugs by HPLC In this thesis a RP-HPLC method for fast and reliable determination of lipophilicity was proposed and tested. Stationary phase was selected by using hydrophobic substraction model. Capacity factors of the chosen substances were initially measured on Zorbax ECLIPSE XDB C18 250x4,6 mm, 5µm column, which exhibits almost identical retention characteristics as the column used for this purpose until now. Then the capacity factors of the same substances were determined by using Zorbax ECLIPSE XDB-C18 50x4,6 mm, 1,8µm column that was selected to reduce retention times significantly. A group of newly synthesised drugs based on structure of pyrazine served as samples for the measurement. The reproducibility of the capacity factor values determined using both columns was compared and the independence of the capacity factor on the mobile phase flow was confirmed. The capacity factors of two homologous series and a group of benzimidazols were consequently determined on Zorbax ECLIPSE XDB-C18 50x4,6 mm, 1,8µm column using various compositions of mobile phases. Several...
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Edward Evan Evans-Pritchard - Theory of Witchcraft and Other Mystic Phenomena
Jurásková, Kamila ; Dvořáková, Markéta (advisor) ; Kubišová, Zuzana (referee)
The diploma thesis deals with witchcraft and other mystic phenomena in conception of Edward Evan Evans-Pritchard. It is focused especially on the notion of witchcraft in connection with magic, shamanism and oracles. It describes relation of all these phenomena towards religious belief and various attitudes towards them. It defines respective practices and explains differences between them. Last but not least, it introduces usual reactions to them. Via concrete situation it also shows interconnection of all described phenomena and presents them as a coherent and logical system.
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Intravenous Drug Administration and Dilution
Karlecová, Markéta ; Bartůňková, Pavla (referee) ; Marková, Eva (advisor)
The goal of this elaborate work was to describe the most often medication misconducts, errors and risks during the intravenous drug administration and dilution in the field of primary care in the Intensive Care Unit - ICU. My interest was to find out about local ICU's standards and regulations and to survey how knowledgeable nursing stuff is towards medication hazard regulation and its affect. The first theoretical part concentrates on conception of IV drug administration and dilution. It charts and shows the situation at the current time. Empirical section of my elaborate work shows findings based upon questionnaire. It serves the purpose of hypothesis verification and confirms the goals of my study. Obtained information should be a foundation for future processing and utilization standards regulation or recommendation how to safely administrate intravenous drugs.
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Electronic auction in healthcare
Vyoral, Marek ; Toth, Štefan (advisor) ; Jan, Jan (referee)
Working with the theoretical part focuses on the regulation of electronic auctions in terms of legislation both Czech and foreign, given that we are members of the European Union. Furthermore, the work explains the possible ways to use electronic auctions, which are mostly used in both the Czech Republic and abroad. At work I also am trying to shed light on the current use of auctions on the auction portal Aukro examples, which is widely used by people for personal use. Finally, the theoretical part I try to outline the future development of electronic auctions. The practical part is focused primarily on its activities in the hospital Pardubice Region, Inc. where I introduced the auction. In several examples, visible results, which not only brings centralization entire purchase, but also the use of electronic auctions as a tool for communication and bidding suppliers with the lowest purchase price for a group of hospitals. The work also draws from the Ministry for Regional Development, which is responsible for the preparation of the most important regulations for electronic auctions in healthcare, namely the Public Procurement Act. Electronic auctions are a tool very interesting, because it is the most transparent way of evaluating procurement by parameters rates. Whether if electronic auction in health care and efficient purchase option will be discussed in this work.
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Contemporery state produced infuse pump.
Hubáček, Jan ; Brandejs, Jan (referee) ; Venclík, Jiří (advisor)
The purpose of this bachelor tesis is to make an overwiev about contemporary state of knowledge about infusion pumps. Labour is locate to infusoin pump characteristic and constructional solving of kinetic mechanism. First part is a characterization of products from inland and external producers. Second part is pointed to the opinion poll of infusion pumps use. Close of this labour is oriented to knowledge summary and incoming development of infusion pumps.
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Portfolio of generic pharmaceutical company focused on maximized sales
Kadlecová, Lenka ; Lešetický, Ondřej (advisor) ; Komárková, Lenka (referee)
The diploma thesis deals with definition of the main part of optimal portfolio of pharmaceutical company. The goal of the thesis is to identify top ten anatomical-therapeutic groups by sales, which can set up the main part of maximized sales portfolio. Approach of the diploma thesis is authentic strategic decision of man-agement of generic pharmaceutical company that penetrates Czech market. Dispensable materials for manager decisions consist of common access resources. Materials go with information about competition's sales, figures about the medication's movement in distribution chain and data of payer's costs. The decision will be made in simple one-criterion choice. The significance of the anatomical-therapeutic groups will be confirmed by epidemiological data.
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The specifics of the placement of the selected medicaments in the hospital ward
JEREMIÁŠOVÁ, Lucie
Subject of the thesis "The specifics of the storage medicaments in the hospital department " was chosen for the fact that this issue applies to all hospitals as well as medical staff. The theoretical part is devoted to medicines and their forms , route of administration, general storage options and selected medicaments , information about them and the rules of their storage. The thesis should find out whether the hospital staff know how to treat with medication. This activity should be considered as a possibility of improving the quality of care in hospitals. The hospital staff must meet all the expectation and requirements which bring them a lot of complications. Also the new distributors of medicines , pharmaceutical companies, and everybody who is involved in the production and distribution of drugs complicate their situation. Neither of these people they do not facilitate their work , changes in the inscriptions , names and appearance of the packaging on medicines is one of the other complications in their work, but they must respect the laws and standards based on them. This thesis has two objectives. The first objective should be identified nurses' knowledge of specifics drugs. This objective is: " To determine whether the nurses know the specifics about saving medicaments in the hospital department. " This was determined by the research question : " What are the specifics of the selected medicaments on the ward? " In the second objective we wanted to map out how nurses obtain information about the storage of medications. This objective is: "Find out how nurses acquire information about saving medicaments in the department. " The research question is : " How do nurses get information about saving medicaments ?" The research is devoted to general nurses in the hospital in Jindřichův Hradec. Research assistance to be given to whether nurses have the correct information on how to store the medication and how information is gathered . Their work is not easy. All workers must manage their specific role and other related work. In the research involved 80 nurses from 9 hospital departments of the hospital Jindřichův Hradec. The research used a quantitative survey using questionnaires. The research was conducted at the Hospital in Jindřichův Hradec, 111 questionnaires were distributed , the final number of respondents was set at 80 participants . 80 respondents represent 100 %. Data obtained from the questionnaires were analyzed using graphs. The survey took place in April 2014. Permission to create research was verbally approved by the head of nurses Dana Běhounová. She received a questionnaire which was used to create the research. The staff in each department where the research took place , was verbally asked whether they want to participate in the research . The data from the questionnaires were processed and put into graphs using Microsoft Excel. The graphs are described in detail. Both objectives were met using the results of research and the questions were asked. Respondents answered all required questions correctly and it is obvious that they know how to treat drugs as well as the necessary information can obtain properly. The research results can be used as teaching material in schools for hospital staff and the results can be aware of the institution where the research was conducted , if these results will be point of interest. The results can be provided to nurses who participated in the research . According to the results of this research, the hospital can make further steps to improve the quality of care and help to the staff to improve the handle with medicines .
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Safe Drug Handling In Medical Facilities.
MUSILOVÁ, Marie
Translation Czech ? English Abstract: Safe Drug Handling in Medical Facilities The issue of safety in drug handling in medical facilities creates a significant priority in maintaining and increasing the quality of care. The presented bachelor?s work deals with such problems both in theoretical and practical level. In the theoretical part it explains the methods of safe drug handling in all levels of that process, starting from the delivery of drugs from the hospital?s pharmacy, till their liquidation. In the research part it examines the knowledge level of the above problems of nurses in surgery or internal departments of a smaller, however an accredited hospital. The research has been outlined as a quantitative research through questioning ? a questionnaire. There were two objectives set up. Objective 1: To get an overall picture of the nurses? knowledge of handling, distributing and keeping drugs and Objective 2: To get an overall picture whether the nurses are acquainted with the principles of handling opiates. Both objectives have been fulfilled. Based on the objectives 8 hypotheses (H) have been set up: H 1: The nurses are acquainted with correct safeguarding of drugs ? confirmed; 96 percent of respondents master the principles of correct safeguarding of drugs. H 2: The nurses are acquainted with correct storing of drugs ? confirmed. 76 percent of them master the principles of correct storing. H 3: The nurses are acquainted with correct designation of drugs ? confirmed. 97 percent of them master the correct designation of drugs. H 4: The nurses are acquainted with the preparation of drugs ? confirmed. 88 percent of nurses master the correct preparation of drugs. H 5: The nurses are acquainted with the correct administration of drugs ? confirmed. 83 percent of nurses master the principles of correct drug administration. H 6: The nurses are acquainted with correct documentation maintenance when administrating drugs ? confirmed. 97 percent of respondents master the documentation agenda when handling drugs. H 7: The nurses are acquainted with the correct liquidation of drugs ? confirmed. 83 percent of nurses master the principles of correct liquidation of drugs. H 8: The nurses are acquainted with correct opiate handling ? confirmed. 94 percent of nurses are acquainted with the correct opiate handling. All 8 hypotheses have been confirmed. The results of the research will be granted to the Hospital in Pelhrimov, p. o., as a possible contribution to the continuous process of quality improvements. It is possible to find certain sections in the detailed text and the graphic part of the processing of answers to individual questions of the test, where the answers of nurses appeared slightly worse (although in total very good) and the proposal is to support training of employees, internal seminars and a creation of standards. The research presented the knowledge of a selected group of nurses in the Hospital in Pelhrimov, p.o., in the area of drug handling at a high level of quality. There is a possibility of further examination of possible mutual differences in the knowledge of the safe drug handling problems, between nurses in accredited and non-accredited health facilities.
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