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Simulation of action potentials and membrane currents by solving Hodgkin and Huxley equations
Bugnerová, Pavla ; Provazník, Ivo (referee) ; Chmelíková, Larisa (advisor)
The thesis deals with the analysis of the resting membrane potential and action potential mainly on the cell membrane of cardiac cells. Attention is given to the electrical schematic layout of the cell membrane and distribution of current part on the main components. The basis for the creation of a mathematical model and simulation is the differential equations of Hodgkin and Huxley. To the description them of calcium and potassium channel leakage from other models are added. The project explores the possibilities of reproducing the known development of membrane currents in two basic modes (voltage clamp and current clamp). All in user interface MATLAB GUI.
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Robotic hand control by myopotentials
Jablonská, Dominika ; Janoušek, Oto (referee) ; Bubník, Karel (advisor)
The thesis deals with the measurement of myopotecials and their using in controlling the robotic arm. First, it is theoretically described electromyographic signal, his scanning and subsequent processing. There is also described an arm which it is used here. The next aim of this project is paying attention scanning signal on human hands using Biopac system and signal processing in MATLAB with Robotic Toolbox. Also was created a computer model in the user interface GUI.
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Vectorcardograms - long term signals
Sedlář, Martin ; Janoušek, Oto (referee) ; Kolářová, Jana (advisor)
This project deals with anatomy and electrophysiology of heart. It describes the structure of cardiac muscle, mechanism of myocard's contraction, heart work, the origin and registration of electric signals of heart – electrocardiogram (ECG) and vectorcardiogram (VCG). Part of the work is design and creation of a software application for calculation and graphical presentation of vectorcardograms, useful for experimental data available on ÚBMI VUT in Brno.
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Simulation of electrophysiological experiments
Kubáček, Svatopluk ; Provazník, Ivo (referee) ; Rychtárik, Milan (advisor)
Simulation of electrophysiological experiments enables to gain valuable data about bioelectrical processes occurring on isolated cells. This thesis deals with basic principals allowing the creation of bioelectrical phenomenons and measuring techniques that need to be used in order to collect information about these phenomenons. The outcome of the thesis is a programme that serves as an instrument for simulation of measuring techniques applied on Luo-Rudy model. The programme contains basic measuring techniques – current clamp and voltage clamp – providing the possibility to change basic parameters of the model. The results of this work are later compared with the accessible literature.
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3D Model of Cardial Tissue Electrical Propagation
Míková, Monika ; Mézl, Martin (referee) ; Hejč, Jakub (advisor)
The aim of this master thesis is to create a simple 3D electro-anatomical model of cardiac tissue that will be able to simulate the electrical activation in both a healthy heart and a heart with arrhytmogenic substrate. The model of electrical activation is realized in the COMSOL Multiphysics, simulation software for modelling using the finite element method. The Fitzhugh-Nagumo equation was used to model the excitatory feature of the myocardium and 2D models of myocardial tissue describing the propagation of action potential in healthy tissue, ischemic tissue, spontaneous action potential formation in the SA node, and spiral wave formation were first developed based on appropriate parameters. Subsequently, simplified 3D models of the heart describing the spread of excitement in a healthy heart, in the presence of accessory pathway and in third-degree atrioventricular block were created. The simplified 3D heart model offers a compromise between computational load and model complexity and can be used as a diagnostic tool for tissue and whole heart adjustment with appropriate equation parameter settings.
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Fuzzy Neural Networks for Pattern Classification
Ollé, Tamás ; Kontár, Stanislav (referee) ; Vágnerová, Jitka (advisor)
Práce popisuje základy principu funkčnosti neuronů a vytvoření umělých neuronových sítí. Je zde důkladně popsána struktura a funkce neuronů a ukázán nejpoužívanější algoritmus pro učení neuronů. Základy fuzzy logiky, včetně jejich výhod a nevýhod, jsou rovněž prezentovány. Detailněji je popsán algoritmus zpětného šíření chyb a adaptivní neuro-fuzzy inferenční systém. Tyto techniky poskytují efektivní způsoby učení neuronových sítí.
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Electromyography
Svobodová, Eva ; Bubník, Karel (referee) ; Chmelař, Milan (advisor)
The first part of this bachelor´s thesis is focused to elements of the muscle and nerve structures and spreading of excitation (signal) through them. Second part is concerned to electromyography as an investigative method that is used in medical diagnostics and basic requirements for the electromyography and its components. In this thesis is described examinational techniques motoric and sensitive nerve conduction. There are described requirements of recording, stimulation and also evaluation of constituent elements of signal. The final part is focused on specific laboratory exercises with specific instructions.
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Modeling of calcium dynamics in excitable and non-excitable cells
Tkáč, Jan ; Čmiel, Vratislav (referee) ; Rychtárik, Milan (advisor)
This bachelor thesis deals with electrophysiologic phenomenons on molecular and cellular level. The aim is to provide basic information for better understanding of simple cellular models. This work also discusses principles of calcium dynamic modelling in cells. In Matlab environment the Lou-Rudy model from 1991, Lou-Rudy model from 1994 and the phantom burster model for pancreatic ß-cells are implemented. Using the GUI interface a clear program for simulation electrophysiologic phenomenons is created.
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Fuzzy Neural Networks for Pattern Classification
Ollé, Tamás ; Raida, Zbyněk (referee) ; Vágnerová, Jitka (advisor)
Práce popisuje základy principu funkčnosti neuronů a vytvoření umělých neuronových sítí. Je zde důkladně popsána struktura a funkce neuronů a ukázán nejpoužívanější algoritmus pro učení neuronů. Základy fuzzy logiky, včetně jejich výhod a nevýhod, jsou rovněž prezentovány. Detailněji je popsán algoritmus zpětného šíření chyb a adaptivní neuro-fuzzy inferenční systém. Tyto techniky poskytují efektivní způsoby učení neuronových sítí.
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Biosignal processing - clusetr analysis
Příhodová, Petra ; Maděránková, Denisa (referee) ; Kolářová, Jana (advisor)
This thesis deals with the problem with cluster analysis and biosignal classification options. The principle of cluster analysis, methods for calculating distances between objects and the standard process in the implementation of clustering are described in the first part. For biosignals processing,it is necessary to get familiar with the primary parameters of these signals in the following sections of thesis, process biosignals and methods for recording of action potentials described. Based on studying different clustering methods is presented a program with the applied method kmedoid in the next section of this thesis. The steps of this program are described in detail and in the end of thesis functionality is tested on a database of signals ÚBMI.
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