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Chemical and microstructural analysis of brick samples from the object of Zákupy castle horse stables
Frankeová, Dita ; Bauerová, Pavla ; Náhunková, Pavla ; Ševčík, Radek ; Mácová, Petra ; Slížková, Zuzana ; Vondráčková, Michaela
As part of the construction-technical survey, historical brick samples were characterized using thermal analysis (TGA), scanning electron microscopy (SEM/EDS), ion chromatography (IC), infrared spectrometry (FTIR) and physical tests. The results of the tests testify to the good production quality of the masonry elements used. Based on the analyzes carried out, it can be assumed that the observed damage to the bricks is caused by high wetting of the masonry in combination with frost cycles, as well as crystallization cycles of water-soluble salts present in the surface layer of some bricks.
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Tumor suppressor NDRG1 and its regulation by iron chelators
Vondráčková, Michaela ; Truksa, Jaroslav (advisor) ; Brábek, Jan (referee)
Iron is an essential trace element required for many processes within a cell, including DNA synthesis and cell cycle progression. Moreover, it is critical for cellular respiration in mitochondria. Due to their proliferative nature, cancer cells are dependent on iron, and depleting this element via iron chelators results in the inhibition of ribonucleotide reductase, leading to cell cycle arrest and apoptosis of cancer cells. Recently, an alternative mechanism for the effect of iron chelators have been proposed, including induction of N-myc downstream regulated gene 1 (NDRG1) expression and its inhibitory effect on c-MET, EGFR, and NF-κB pathways, which can act as oncogenes in a certain context. NDRG1 is a tumour suppressor gene, which is downregulated in many cancers and its downregulation correlates with cancer progression, poor differentiation, and higher metastatic potential. It has been shown that NDRG1 expression can be regulated by intracellular iron - a decrease in intracellular iron leads to upregulation of NDRG1 at mRNA and protein level via the HIF-1-dependent mechanism by inhibiting prolyl hydroxylases. Recently, we have conceived the concept of mitochondrially targeted chelators as an effective anti-cancer agent and in this work, we focused on the evaluation of mitochondrially targeted...
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Neoangiogenesis as a target for tumor therapy
Vondráčková, Michaela ; Sivák, Ladislav (advisor) ; Dibus, Michal (referee)
Neoangiogenesis associated with tumours is formation of new blood vessels from pre-existing quiescent vessels in surrounding tumour tissue and it results from pathological employment of normal angiogenesis. Neoangiogenesis became a promising target for cancer treatment in spite of its complexity and many pro-angiogenic and anti-angiogenic factors involved in this process. Anti-angiogenic strategies are based on neutralization of angiogenic ligands, their receptors or inhibition of signalling pathways employed by such receptors. Other potential strategies include upregulation or delivery of endogenous inhibitors, inhibition of endothelial cell proliferation, stabilization of basement membrane and direct disruption of tumour vasculature. Many anti-angiogenic agents have been identified in past several decades but only a few of them were approved for clinical use. Anti-VEGF-A monoclonal antibody bevacizumab (Avastin® ), soluble decoy VEGF receptor aflibercept (Zaltrap® ), monoclonal antibody directed against VEGFR-2 ramucirumab (Cyramza® ) and tyrosin kinase VEGFR inhibitors sunitinib (Sutent® ) and sorafenib (Nexavar® ) belong among approved agents. Key words: angiogenesis, neoangiogenesis, anti-angiogenic therapy, HIF-1, VEGF, bevacizumab
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Corporation Income Tax in CR and Germany
Vondráčková, Michaela ; Marková, Hana (advisor)
The Bachelor Thesis deals with the concept of international taxation of Permanent Establishment, precisely with the focus on Corporation Tax. Aim of this work is to define and compare how Czech, German and international laws look at Permanent Establishment and its taxation. At the beginning, there is focus on definition of Corporation Tax, afterwards on Permanent Establishment itself. At the end, there is mentioned a judicial case related to this topic.
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