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Performance measuring of individuals with physical handicap
Vít, Ondřej ; Kálal, Jan (advisor) ; Radvanský, Jiří (referee)
The thesis is focused on the measurement of the energy consumption during the locomotion of the mobility disabled (riding a wheelchair a walking with 2 point support - crutch). The probands were handicapped by partial amputation of lower limb based on the vascular cause which represents approximately 90 percent of all amputations done in the Czech Republic. The thesis also presents a brief classification of amputations according to the extent of the separation, the history of amputations and the main etiologic factors leading to amputation. In the result section the measured data are discussed. In the last part of the thesis, the conclusions are discussed and compared to information available from similar studies. Powered by TCPDF (www.tcpdf.org)
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Studies of minor capsid proteins of the mouse polyomavirus
Vít, Ondřej ; Němečková, Šárka (referee) ; Forstová, Jitka (advisor)
Mouse polyomavirus (MPyV) is a small non-enveloped virus. Its capsid consists of 72 pentamers of the major capsid protein VP1. The central cavity of each VP1 pentamer contains one minor capsid protein, either VP2, or VP3. The minor capsid proteins are dispensable for capsid formation, but their presence is required for infection of the host cell, presumably because of their anticipated functions during virus entry. After internalization, MPyV virions traffic to endoplasmic reticulum (ER). VP2 and VP3 have been proposed to function as factors responsible for penetration of ER membranes, which is required for subsequent delivery of the viral DNA into the nucleus, a key step of the early phase of MPyV infection. Three hydrophobic domains were predicted in the sequence of VP2 and VP3. First in the unique Nterminal part of VP2, second and third in the common part of VP2 and VP3. The third domain corresponds to C-terminal VP1binding alpha-helix. It has been previously found in our laboratory, that VP2 and VP3 fused to N-terminus of EGFP, when expressed in mammalian cells, display properties similiar to the wild-type VP2 and VP3, namely affinity to intracellular membranes and high cytotoxicity. Expression plasmids carrying mutated VP2 and VP3 fused to Nterminus of EGFP were prepared to determine the hydrophobic...
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Effect of taxes on economic growth in developed countries after 1945
Vít, Ondřej ; Ježek, Tomáš (advisor) ; Vebrová, Ludmila (referee)
The most discussed topics in economics is the relationship between economic growth and taxes. The aim of this study is to evaluate the influence of different types of taxes on economic growth of Organisation for Economic Co-operation and Development (OECD) member countries after World War II. The thesis is based on extended neoclassi-cal growth theory from 1992 by Mankiw - Romer - Weil. Regression Analysis of Panel Da-ta is used as technique for verification of the correlation of economic growth and taxation. The impact of taxation is integrated to the model through its effect on accumulation of physical capital, development of human capital and technology. The source of panel data used in the analyses is statistical databases of OECD, World Bank, Maddison historical data and Penn World Table. For better comparison of the results more different methods of measuring tax burden were used. It was share of tax income on GDP, share of income from different types of taxes on total tax revenue, labor tax and compound tax quota. Results than differ by measurement of tax incidence. It is too complex to set clear recommendation for growth, nevertheless it is obvious, that the goal of economic and political authorities is to shift the tax burden from direct to indirect taxes.
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Bitcoins: Inception of New Era in Monetary Policy?
Vít, Ondřej ; Doležal, Ondřej (advisor) ; Sunega, Petr (referee)
This work presents an economic analysis of virtual currency and a system of payment known as Bitcoin. From many goals of this work, the main is to answer a question, whether the Bitcoins are to cause revolution at financial markets. To solve this I applied theoretical knowledge of Austrian school on the Bitcoin currency. Given this facts it has turned out, that the nature of Bitcoin truly is revolutionary. However, it would be wrong to assume, that the Bitcoins are to actually spark significant changes in current monetary system. For a better understanding of all circumstances, the development of an exchange and the evolution of money was involved in this work. From an economical perspective, it is obvious, that the Bitcoins certainly are a new kind of currency that flows beside money but also cannot replace it. It is the specificity of the system what creates barriers preventing Bitcoins from becoming more widespread and used more often. The benefits of this thesis lie in a complex economic analysis of Bitcoin currency and a prediction of its future development.
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