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Functional differentiation in the hippocampus
Vondráková, Kateřina ; Telenský, Petr (advisor) ; Stuchlík, Aleš (referee)
This work has been focused on anatomical and functional differentiation of the hippocampus. Hippocampus, as one of the most studied structures in the brain has an irreplaceable role in encoding, consolidation and recall of memories. In the early 20th century, Ramon y Cajal has divided hippocampus into 3 subregions, Ammon's horn (CA1-CA3 region), dentate gyrus and subiculum. Diferences in gene expresion, principal cell features and organization of connections with other structures suggests further division of the hippocampus according to septo-temporal axis, into ventral, dorsal and intermedial zone. Most importantly, the efects of impairment or inactivation of the individual subregions of the hippocampus, allow us to determine their prospective functions.
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Physiological significance of pain
Zámostná, Kateřina ; Vaculín, Šimon (advisor) ; Telenský, Petr (referee)
Pain is defined as a physiological process associated with negative emotional experience which warns our body about impending damage. Apart from neuropathic pain, which by definition has no purpose, pain in effect provides a defensive function. However, this role is already being fulfilled by a different mechanism - the defensive reflex, which is evolutionarily older. Therefore we can ask, whether pain is only an emotional experience attached to this reflex, or if it has its own functions. To determine the physiological purpose of pain a rare syndrome of congenital analgesia, characterized by complete absence of pain, will be used. Based on a comparison of clinical cases of the syndrome with a population without pain disorders individual functions of pain will be described and connected to the individual components of pain - sensory- discriminatiory and affective-motivational. The sensory-discriminatory component provides a defensive, diagnostic and an informative function. The defensive function is analogous to the defensive reflex. The informative function transmits information about a physiological process, where pain plays a key role - labour. Diagnostic function applies in medicine and is based on verbal description of the defensive function. Functions of the SD component are involved at the time of...
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Hyperthermia effects in immature brain
Starý, Robert ; Kubová, Hana (advisor) ; Telenský, Petr (referee)
In this work basic concepts of epileptology are explained first. Next the issue of experimental study is pointed out. The rest of the work is then devoted to febrile seizures, their generation, spread and effect on the organism. Confrontation of seizures associated with increased body temperature and other experimental models are placed at the end.
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Rats of the genus Rattus: their biology and food preferences
Voráčková, Petra ; Frynta, Daniel (advisor) ; Telenský, Petr (referee)
Genus Rattus falls into the most extensive mammalian family Muridae, concretely to subfamily Murinae. The Norway rat (Rattus norvegicus) and black rat (Rattus rattus) are the best known species of genus Rattus. Although the laboratory rat is widely used as model organism, the wild species of genus Rattus cause huge economic losses in agriculture, especially in South East Asia. These commensal rodents are also vectors of zoonotic deseases which can cause human infection. One of the way how to reduce their populations is to study the transmission of food preferences. Well known phenomenon of genus Rattus is the social learning and sharing the experience about food to other individuals. Not only due to this fact is this kind one of the most successful in the animal kingdom.
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Effect of stress on expression of glucocorticoid receptors and enzymes of glucocorticoid metabolism in specific structures of rat brain
Kvapilová, Pavlína ; Pácha, Jiří (advisor) ; Telenský, Petr (referee)
Stress response is trigerred by a number of factors, which, depending on the type of response they generate, involve different brain structures. These structures then relay the information to the paraventricular nucleus of hypothalamus (PVN), which is the main integration center for information about the imbalance of homeostasis induced by stressors. If it meets a sufficient number of excitatory signals, the PVN activates the hypothalamic pituitary adrenal axis, which ultimately triggers the secretion of stress hormones glucocorticoids, which then act back on the brain. This action is influenced by several factors, mainly the presence of local metabolism of glucocorticoids. Local metabolism is provided by the enzymes 11-hydroxysteroid dehydrogenases, which can locally activate or deactivate the hormone molecules and thus amplify or attenuate their effects.
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Pain perception in elders
Vítková, Jana ; Vaculín, Šimon (advisor) ; Telenský, Petr (referee)
The aging of the population is one of the problems of the current period. With increasing age, we have to deal with the accompanying phenomenon more and more - the pain which significantly inconveniences the life and makes normal integration of elderly people into society impossible. This bachelor thesis summarises the present knowledge of pain in elderly people. It addresses the mechanism of pain perception, physiology of aging and types of pain which occur in elderly people. Some types of pain are accompanying diseases which occur during old age - neuropathic, chronic and oncologic pains. The higher occurrence of these types of pain could be explained by the progressive degeneration of nerve system during aging, either due to demyelization and reduction of the number of nerve fibres or due to accumulation of free radicals in the organism. On the other hand, there are some types of pain which elderly people feel with lower intensity - visceral and postoperative pain. At the same time, the pain threshold is increasing in the elderly people. This paradox, i.e. on one hand higher occurrence of chronic pain at higher intensity and on the other hand reduction of visceral pain and postoperative pain could be explained by diffuse noxious inhibitory controls. The current knowledge of the pain in the elderly is...
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Neuropeptide Y and food intake regulation
Váchová, Barbora ; Telenský, Petr (referee) ; Nedvídková, Jara (advisor)
Neuropeptide Y (NPY) is a 36-amino acid member of NPY family. Its biosynthesis occurs in the hypothalamus and its expression also in adipose tissue was described in 2007. NPY is an ubiquitous hormone with central and peripheral effects which lead to the maintenance of homeostasis; NPY is also one of the most significant orexigenic hormones. NPY utilizes G-protein coupled receptors Y1, Y2 and Y5 for its food intake regulation; owing to serious side effects of currently used anti-obesity drugs, the ligands of these receptors (Y1R and Y5R antagonists and Y2R agonists) are considered as targeting molecules for a new therapeutic strategy for obesity treatment. This work is focused on the characteristic of NPY as an orexigenic agent and the possibility of using NPY-based drugs for obesity treatment.
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