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Differences between susceptible and resistant strains of Barber's pole worm (Haemonchus contortus)
Bartásková, Lenka ; Svobodová, Hana (advisor) ; Lecová, Lenka (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Departement of Biochemical Sciences Candidate: Lenka Bartásková Supervisor: Mgr. Hana Bártíková, Ph.D. Title of the thesis: Differences between susceptible and resistant strains of Barber's pole worm (Haemonchus contortus) Haemonchus contortus is very common parasite. It can infect a large number of ruminant species and is a very dangerous parasite of sheep and goats worldwide. The infection caused by these worms is called haemonchosis. The symptoms are anaemia, loss of weight and death of the infected sheep and goats. Nowadays we can prevent this disease. The prevention of haemonchosis is available in the form of anthelmintic drugs. The most commonly administered drugs from this category are represented by benzimidazoles. However, the frequent use of anthelmintic leads to development of drug resistance in parasites. The resistance to anthelminthic drugs is caused by mutation at codon 200 of β-tubulin. The worms Haemonchus contortus can be divided into sub-groups according to their anthelmintic resistance. This thesis compares the number of alleles responsible for resistance in sensitive and resistant strains of Haemonchus contortus. A low percentage of the resistant allele is found in the sensitive strain ISE. In the resistant...
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Art spaces in geographical contexts: the case of Karlovy Vary
Adamec, Vítězslav ; Matoušek, Roman (advisor) ; Svobodová, Hana (referee)
This bachelor thesis is devoted to art spaces in Karlovy Vary and geographical contexts related to them. By using interviews with representatives of these spaces is obtained the image of culture of Karlovy Vary from a spaces players' perspective. Geographical context was understood by various levels of the scale, from the close environs to the influence of international events. Next research question was devoted to political and economic influences on the cultural life of the city and eventually it was turned attention to the net of mutual relations between culture players in Karlovy Vary. The thesis pointed to the contradictoriness of contemporary cultural situation of the city, which is the expression of the imbalance between the free activity of art spaces and the pressure to the economic profit. Keywords: cultural geography, urban geography, art spaces, art, cultural policy, geographical context
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Nursing care about patient with uterine prolapse
Chadrabová, Štěpánka ; Svobodová, Hana (advisor) ; Popelka, Jiří (referee)
This work deals with the nursing care about a patient related to uterine prolapse. The theoretical part provides information on anathomy and physiology of female reproduction organs, it summarises possible solutions of the problem of uterine prolapse and it briefly describes possible surgery. The clinical part presents a case report of a patient who underwent vaginal hysterectomy. The nursing process is based on the model by M. Gordon. A special attention is paid to the patient's mental state.
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The effect of green tea polyphenols on antioxidant enzymes in mice in vivo
Kvita, Vojtěch ; Svobodová, Hana (advisor) ; Matoušková, Petra (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Vojtěch Kvita Supervisor: PharmDr. Hana Bártíková, Ph.D. Title of diploma thesis: The effect of green tea polyphenols on antioxidant enzymes in mice in vivo Antioxidant enzymes belong to compounds with proven effects on human organism. Their main purpose is to defend cells against oxidative stress. In order to support this process, we are taking substances called antioxidants either in regular diet or as dietary supplements. Recently there are a lot of companies on the market, offering the supplement, promising wight loss or defence against cancer. Green tea contains many natural substances, such as polyphenolic compounds which include catechins, which have proven effects on our bodies, but the specific way they act on selected antioxidant enzymes is still matter of study. The aim of this work was to determine the effect of green tea polyphenols on antioxidant enzymes in mice. We studied 8 groups (4 normal, obese 4) wherein the two groups were left as a control which means without administration of Polyphenon. Three groups were given a Polyphenon enriched diet and for various period of time (28 days, 3 days) and at different concentrations (0.1%, 0.01%). Activity was studied in liver...
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The impact of cranberry extract and obesity on antioxidant enzymes in mice in vivo
Vášková, Lucie ; Svobodová, Hana (advisor) ; Hanušová, Veronika (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Lucie Vášková Supervisor: PharmDr. Hana Bártíková, PhD. Title of diploma thesis: The impact of cranberry extract and obesity on antioxidant enzymes in mice in vivo The obesity is the worldwide problem nowadays which threatens health of millions of people. The obesity is characterized as an excessive increase in the content of body adipose tissue. Increased quantity of adipocytes produces oxidized LDL particles which are deleterious for the body and damage the tissue of the organism. Fruit of Vaccinium macrocarpon contains range of natural substances. Proven effects of cranberries include action on the urinary tract infections, anti-atherogenic effects in the cardiovascular system, anticancer, antiulcer effect and also acts againts the development of the obesity. Most of these effects are largely determined by antioxidant actions of contained substances, particularly anthocyanidins. Recently, the nutritional supplements containing cranberries which are used frequently as a substitute for a varied diet or weight reduction have became very popular. The first aim of my study was to determine the influence of obesity on selected antioxidant enzymes of mice in vivo. Obesity by monosodium...
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The effect of green tea polyphenols on antioxidant enzymes in mice in vivo
Kvita, Vojtěch ; Svobodová, Hana (advisor) ; Matoušková, Petra (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Vojtěch Kvita Supervisor: PharmDr. Hana Bártíková, Ph.D. Title of diploma thesis: The effect of green tea polyphenols on antioxidant enzymes in mice in vivo Antioxidant enzymes belong to compounds with proven effects on human organism. Their main purpose is to defend cells against oxidative stress. In order to support this process, we are taking substances called antioxidants either in regular diet or as dietary supplements. Recently there are a lot of companies on the market, offering the supplement, promising wight loss or defence against cancer. Green tea contains many natural substances, such as polyphenolic compounds which include catechins, which have proven effects on our bodies, but the specific way they act on selected antioxidant enzymes is still matter of study. The aim of this work was to determine the effect of green tea polyphenols on antioxidant enzymes in mice. We studied 8 groups (4 normal, obese 4) wherein the two groups were left as a control which means without administration of Polyphenon. Three groups were given a Polyphenon enriched diet and for various period of time (28 days, 3 days) and at different concentrations (0.1%, 0.01%). Activity was studied in liver...
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Social Inequalities in the Jakarta Metropolitan Area
Horňáková, Marie ; Temelová, Jana (advisor) ; Svobodová, Hana (referee)
This bachelor thesis deals with social inequalities in the Jakarta Metropolitan Area. It is focused on the problematic of social exclusion in relation with the distribution of different groups of the population in the metropolitan region - especially on the differences between core and peripheral areas. Monitoring of the social differences is set in the context of post-suburbanisation and the entire work is based on theories of postmodern urbanism. In the case of segregation of population it is primarily focused on the main reasons leading to this process - differences in ethnicity and ensuring security. In the context of higher degree of security it focuses on other indicators, which could be expected to be related with it. Data from the Indonesian Bureau of Statistics have been used in the processing. The results indicate that differences exist not only between the core and suburban areas, but also within the edges themselves. Key words: Jakarta Metropolitan Area, post-suburbanisation, postmodern urbanism, social exclusion
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