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Functional assessment of motor activities of patients after brain damage before and after intensive rehabilitation intervention (with the goal to obtain restoration of upper arm physiological functions)
Sládková, Petra ; Švestková, Olga (advisor) ; Jeřábek, Jaroslav (referee) ; Süssová, Jana (referee)
Rehabilitation of patients after brain damage is an multidisciplinary, complex, intensive, long- term and individual process. Standardized functional instruments for the assessment of the degree of disability and functional abilities of patients are not usually used in rehabilitation in the Czech Republic. Often, motor disorder post brain damage results in hemiparesis and causes impairment of upper arm movement pattern. Movement ability of the upper arm is vital for self-sufficiency, activities of daily life and maintaining an independent family life. Special rehabilitation therapeutic techniques must involve the training of new activities including the mechanism of motor learning which is responsible for functional reorganization of the motor cortex regions, and the activation of reserve neurons for reparation. The aim of the study is to demonstrate that an accelerometer is a suitable instrumet for objective monitoring of impairment of the upper arm movement pattern. Another aim of the study is to demostrate if the FIM test (Functional Independence Measures) and Jebsen-Taylor (JT) test are appropriate instruments for detecting changes of the upper arm movement pattern after intensive, individual and multidisciplinary rehabilitation brain damage patients. Clinical study was undertaken with selected...
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Functional assessment of motor activities of patients after brain damage before and after intensive rehabilitation intervention (with the goal to obtain restoration of upper arm physiological functions)
Sládková, Petra ; Švestková, Olga (advisor) ; Jeřábek, Jaroslav (referee) ; Süssová, Jana (referee)
Rehabilitation of patients after brain damage is an multidisciplinary, complex, intensive, long- term and individual process. Standardized functional instruments for the assessment of the degree of disability and functional abilities of patients are not usually used in rehabilitation in the Czech Republic. Often, motor disorder post brain damage results in hemiparesis and causes impairment of upper arm movement pattern. Movement ability of the upper arm is vital for self-sufficiency, activities of daily life and maintaining an independent family life. Special rehabilitation therapeutic techniques must involve the training of new activities including the mechanism of motor learning which is responsible for functional reorganization of the motor cortex regions, and the activation of reserve neurons for reparation. The aim of the study is to demonstrate that an accelerometer is a suitable instrumet for objective monitoring of impairment of the upper arm movement pattern. Another aim of the study is to demostrate if the FIM test (Functional Independence Measures) and Jebsen-Taylor (JT) test are appropriate instruments for detecting changes of the upper arm movement pattern after intensive, individual and multidisciplinary rehabilitation brain damage patients. Clinical study was undertaken with selected...
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Multiple sclerosis and the measurement of T2 relaxation time in the central gray matter structures of the brain
Burgetová, Andrea ; Vaněčková, Manuela (advisor) ; Süssová, Jana (referee) ; Lisý, Jiří (referee)
Objective: The aim is to adduce the quantitative evidence of increased iron accumulation in the basal ganglia in multiple sclerosis (MS) patients in comparison with the control group. Another aim is to determine the relationship between iron accumulation and other parameters determined in MS: lesion load (LL), brain parenchymal fraction (BPF). Patients and methods: T2 relaxometry (T2) was used for the measurement. 970 patients with clinically defined MS and 117 controls, incl. the MultiechoGrase sequence, were examined by MR to calculate T2. Patients were then divided into 3 subgroups according to LL value and into 3 subgroups according to BPF. T2 was correlated between groups age matched. Conclusions: This work provided quantitative evidence of the increased accumulation of iron in the basal ganglia in patients with MS in comparison with the healthy controls. We subsequently found a higher accumulation of iron in the basal ganglia in the subgroup with a smaller volume of plaques (according to LL) than in healthy controls and in the subgroup with a larger volume of LL. The hypothesis of a neurodegenerative component to this disease is supported by the changes in iron content in the brain.
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Sec. Progressive Form of Multiple Sclerosis : Brain Atrophy and Leasion Load in MRI
Mašek, Martin ; Seidl, Zdeněk (advisor) ; Süssová, Jana (referee) ; Lisý, Jiří (referee)
Secondary progressive form of multiple sclerosis (SPMS) is characterized by a steady progression of clinical neurological damage with or without superimposed relapses and minor remissions and plateaus. Patients who develop SPMS will have previously experienced a period of RRMS, most of the untreated patients with RRMS will go on to develop SPMS in 10-20 years, time to transition is prolonged with a proper therapy. Based on clinical status alone, it is difficult to precisely establish when RRMS converts to SPMS although it is clearly important for appropriate treatment. The aim of the study was to monitor the interaction between the clinical manifestation of the SPMS expressed in the Expanded Disability Status Scale (EDSS) and abnormal findings in magnetic resonance imaging (MRI) of the brain. Twelve patients diagnosed with SPMS were included in this study, once a year the evaluation of the clinical status of the patient expressed in EDSS was performed, usually at the time of MRI examination. All patients underwent a MRI examination every 12 months for 3 years. Utilizing a special program developed in our Institution , the following parameters were evaluated during each MRI examination: brain tissue volume (brain atrophy status), lesion load in FLAIR sequence, volume of ""black holes"" (volume of...
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