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Natural drugs in cancer treatment and their cytotoxicity
Hájková, Tereza ; Raudenská, Martina (referee) ; Provazník, Ivo (advisor)
The thesis deals with the natural substances in context with the cancer disease. The natural substances have a positive effect on the human organism and they are able to influence the viability and the growth of the cancer cells. The main mechanical device is to influence the mechanisms needed to start the apoptosis of the cancer cells and stopping further proliferation. The cancer cell lines utilization in the cancer disease is discussed in the thesis too. The thesis states common methods of determining the natural substances cytotoxicity. For the experimental part of the thesis it was chosen the MTT test method and the xCELLigence system for monitoring in real time. The mechanical device of the tested substance capsaicin in application on the prostate cell lines, tumorous PC3 and nontumorous PNT1A influence will be observed within the experimental part of the thesis.
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Bioinformatics of human genome
Kupková, Karolína ; Provazník, Ivo (referee) ; Maděránková, Denisa (advisor)
Bachelor thesis deals with DNA segments containing only adenine and guanine. The theoretical part describes the structure and composition of deoxyribonucleic acid, chromosomes and genes. There are basic informations about chimpanzees and the human genome and conformations of the chains containing adenine with guanine. The practical part consists of a program that searches for the required sections in sequence, it displays and saves it. The thesis includes analysis of genes which are common for humans and chimpanzees, which were analyzed to determine randomness, functionality a preserving of these sections.
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Neuroinformatics: calibration methods in multicentric MR studies
Kovalčík, Tomáš ; Říha, Ivo (referee) ; Provazník, Ivo (advisor)
Work deals with methods of calibration of multi-center study of magnetic resonance imaging. Magnetic resonance is the phenomenon of the substance in a magnetic field of induction B0 delivers energy in the form of RF pulse with the Larmor frequency and thus to excite particles to higher energy levels. Calibration can be performed using the distinctive and homogeneous RF phantoms. Furthermore, we can perform calibration using image registration. To calibrate the images by registering the work described in the classical linear (affine) and nonlinear. Listed below are the simulators, which are also useful for modeling various artifacts.
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Security of Biometric Systems
Lodrová, Dana ; Busch, Christoph (referee) ; Provazník, Ivo (referee) ; Drahanský, Martin (advisor)
Hlavním přínosem této práce jsou dva nové přístupy pro zvýšení bezpečnosti biometrických systémů založených na rozpoznávání podle otisků prstů. První přístup je z oblasti testování živosti a znemožňuje použití různých typů falešných otisků prstů a jiných metod oklamání senzoru v průběhu procesu snímání otisků. Tento patentovaný přístup je založen na změně barvy a šířky papilárních linií vlivem přitlačení prstu na skleněný podklad. Výsledná jednotka pro testování živosti může být integrována do optických senzorů. Druhý přístup je z oblasti standardizace a zvyšuje bezpečnost a interoperabilitu procesů extrakce markantů a porovnání. Pro tyto účely jsem vytvořila metodologii, která stanovuje míry sémantické shody pro extraktory markantů otisků prstů. Markanty nalezené testovanými extraktory jsou porovnávány oproti Ground-Truth markantům získaným pomocí shlukování dat poskytnutých daktyloskopickými experty. Tato navrhovaná metodologie je zahrnuta v navrhovaném dodatku k normě ISO/IEC 29109-2 (Amd. 2 WD4).
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Binocular vision
Bršlicová, Tereza ; Provazník, Ivo (referee) ; Kolář, Radim (advisor)
This bachelor thesis deals with the physiology of binocular vision to obtain spatial effects of two-dimensional images. The thesis contains description of the anatomy and physiology of the organ of sight. The work deals with the binocular vision itself and concepts associated with it, the pathology, examination and development of binocular vision. The next chapter concerns the stereoscopy, a technology that enables to perceive two-dimensional objects in 3D space, which is an integral part of the topic. There are also descriptions of individual stereoscopic projection technology, especially passive stereoscopic technology used in the practical part of the thesis. The practical part focuses on design of dynamic and static scenes using a pair of identical video cameras (VCRs) to obtain data for the production of stereoscopic recording. A description of designed scenes and its projection via passive stereoscopic technology to a group of volunteers is provided as well. The questionnaires assessed the quality of spatial effects.
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Methods of processing Oxford Nanopore sequencing data for metagenomics
Barilíková, Lujza ; Provazník, Ivo (referee) ; Kupková, Kristýna (advisor)
The revolutionary sequencing technology introduced by Oxford Nanopore Technologies – MinION holds a great promise in the field of metagenomics. Low cost, produced long reads and portability, due to its small dimensions, represents only one of the many advantages of this technology. Despite the benefits, there is a lack of available computational tools for handling the produced data. The theoretical part of the thesis first introduces current sequencing technologies with main focus on the third-generation sequencing and especially on nanopore sequencing. The recent possibilities of metagenomic data visualization are introduced. The main purpose of the bachelor thesis is to make an algorithm for binning of metagenomic samples based on use of dimensionality reduction techniques straight on raw data produced by nanopore sequencing.
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A Wavelet-Based QRS-Complex Detection
Kocian, Ondřej ; Provazník, Ivo (referee) ; Kozumplík, Jiří (advisor)
This project investigates methods of construction the wavelet-based QRS-complex detector. QRS-complex detection is very important, because it helps automatically calculate heart rate and in some cases it is used for compression ECG signal. The design of QRS detector can be made with many methods, in this project were mentioned and consequently tested only a few variants. The principle of designed detector used a wavelet-based decomposition of the original ECG signal to several frequency-coded bands. These bands are consequently transformed to absolute values and with the help of the threshold value are marked positions of assumed QRS complexes. Then are these assumed positions from all bands compared between themselves. If the position is confirmed at least at one nearby band, then is this position marked as true QRS complex. To increase efficiency of designed detector, two modifications were additionally mentioned. The first one, using the envelope of the signal, had rather negative effect on detectors efficiency. The second modification, using combined signal from three pseudoorthogonal leads, had reversely very good effect on detectors efficiency. In the end, the designed detector and all its modifications were tested on signals from CSE library (exactly on leads II, V2 and V6).
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Evaluation of the Wi-Fi technique for use in a navigated orthopedic surgery
Truhlář, Jindřich ; Sekora, Jiří (referee) ; Provazník, Ivo (advisor)
Following text focuses on use of wireless technologies in OrthoPilot navigation system developed by B.Braun company. Description of OrthoPilot software is followed by overview of available wireless technologies highlighting their both advantages and disadvantages. Practical part consists of two main parts, mostly dealing with electronic circuits. First part describes development process of camera-wireless printed circuit board which substitutes currently used RS-422 cable connection between PC and stereo camera. Part of this chapter covers programming in C++ in order to make interface compatible with the rest of current OrthoPilot software. Second bigger part deals with remote controller development using prototyping board mikroMedia for XMEGA. Besides electrical circuits design, chapter describes also software part - microcontroller programming in C language. Thesis is concluded by discussing system limitations and ideas for future development.
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