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Proposal for the corporate design of FTVS UK
Lhota, Filip ; Janák, Vladimír (advisor) ; Voráček, Josef (referee)
Title of study: Proposal for the corporate design of FTVS UK Study aim: An analysis of the present situation in the area of the faculty's visual style and proposals for its amelioration by means of a graphic manual. Method: Analysis of internal and external documents and a semi-structured interview are used in this Master's Thesis. Results: A complete graphic manual of FTVS will be presented as a final proposal for an amelioration of the present state. Key words: company communication, company identity, corporate design, logo, graphic manual
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Marketing research of value of the brand Puma
Lhota, Filip ; Voráček, Josef (advisor) ; Šíma, Jan (referee)
My thesis introduces a problem of value identification concerning the brand Puma in the Czech Republic. The main objective of this thesis is to find out how is Puma perceived by the Czech population as well as how satisfied and familiar is the Czech population with its products. The theoretical part of the thesis will deal with obtaining information and defining terms in field of marketing research, brand value and propagation. The practical part will include data collection and its processing, which will enable this research to present concrete results. The techniques I will use are electronic questionnaire and depth interview. Keywords: brand, promotion, sponsorship, marketing research
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Identification of hereditary alterations predisposing to breast cancer development using "next-gen" sequencing
Lhota, Filip
Summary: Breast cancer (BC) is the most frequent cancer type in female population of Europe. Approximately 5 - 10 % accounts for its hereditary form which is characterized by high penetrance, early onset, risen recurrence risk and development of other cancers. Mutational analyses of high risk patients identify a predisposing mutation in one of the most studied genes (BRCA1, BRCA2, TP53, ATM, CHEK2, NBS1, PALB2) only in less than one third of tested breast cancer patients. Lately, with the use of new methods of next-generation sequencing, a number of other susceptibility or candidate genes were characterized, but the incidence of their pathogenic alteration is often geographically different. A notable proportion of high risk patients from families with hereditary BC can represent carriers of population-specific, or private mutations. Most of the to date identified BC susceptibility genes codes for proteins involved in DNA repair, especially repair of double strand break DNA repair. Nevertheless the mutation analysis was conducted only on a small fraction of these DNA repair genes. We can expect that in the group of yet nontested genes coding for DNA repair proteins a rare, but clinically important genetic alterations predisposing to BC in affected families can be discovered. This work describes a...
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Identification of hereditary alterations predisposing to breast cancer development using "next-gen" sequencing
Lhota, Filip
Summary: Breast cancer (BC) is the most frequent cancer type in female population of Europe. Approximately 5 - 10 % accounts for its hereditary form which is characterized by high penetrance, early onset, risen recurrence risk and development of other cancers. Mutational analyses of high risk patients identify a predisposing mutation in one of the most studied genes (BRCA1, BRCA2, TP53, ATM, CHEK2, NBS1, PALB2) only in less than one third of tested breast cancer patients. Lately, with the use of new methods of next-generation sequencing, a number of other susceptibility or candidate genes were characterized, but the incidence of their pathogenic alteration is often geographically different. A notable proportion of high risk patients from families with hereditary BC can represent carriers of population-specific, or private mutations. Most of the to date identified BC susceptibility genes codes for proteins involved in DNA repair, especially repair of double strand break DNA repair. Nevertheless the mutation analysis was conducted only on a small fraction of these DNA repair genes. We can expect that in the group of yet nontested genes coding for DNA repair proteins a rare, but clinically important genetic alterations predisposing to BC in affected families can be discovered. This work describes a...
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Identification of hereditary alterations predisposing to breast cancer development using "next-gen" sequencing
Lhota, Filip ; Kleibl, Zdeněk (advisor) ; Zikán, Michal (referee) ; Mohelníková Duchoňová, Beatrice (referee)
Summary: Breast cancer (BC) is the most frequent cancer type in female population of Europe. Approximately 5 - 10 % accounts for its hereditary form which is characterized by high penetrance, early onset, risen recurrence risk and development of other cancers. Mutational analyses of high risk patients identify a predisposing mutation in one of the most studied genes (BRCA1, BRCA2, TP53, ATM, CHEK2, NBS1, PALB2) only in less than one third of tested breast cancer patients. Lately, with the use of new methods of next-generation sequencing, a number of other susceptibility or candidate genes were characterized, but the incidence of their pathogenic alteration is often geographically different. A notable proportion of high risk patients from families with hereditary BC can represent carriers of population-specific, or private mutations. Most of the to date identified BC susceptibility genes codes for proteins involved in DNA repair, especially repair of double strand break DNA repair. Nevertheless the mutation analysis was conducted only on a small fraction of these DNA repair genes. We can expect that in the group of yet nontested genes coding for DNA repair proteins a rare, but clinically important genetic alterations predisposing to BC in affected families can be discovered. This work describes a...
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Proposal for the corporate design of FTVS UK
Lhota, Filip ; Janák, Vladimír (advisor) ; Voráček, Josef (referee)
Title of study: Proposal for the corporate design of FTVS UK Study aim: An analysis of the present situation in the area of the faculty's visual style and proposals for its amelioration by means of a graphic manual. Method: Analysis of internal and external documents and a semi-structured interview are used in this Master's Thesis. Results: A complete graphic manual of FTVS will be presented as a final proposal for an amelioration of the present state. Key words: company communication, company identity, corporate design, logo, graphic manual
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Marketing research of value of the brand Puma
Lhota, Filip ; Voráček, Josef (advisor) ; Šíma, Jan (referee)
My thesis introduces a problem of value identification concerning the brand Puma in the Czech Republic. The main objective of this thesis is to find out how is Puma perceived by the Czech population as well as how satisfied and familiar is the Czech population with its products. The theoretical part of the thesis will deal with obtaining information and defining terms in field of marketing research, brand value and propagation. The practical part will include data collection and its processing, which will enable this research to present concrete results. The techniques I will use are electronic questionnaire and depth interview. Keywords: brand, promotion, sponsorship, marketing research
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Study of alternatively spliced variants of estrogen receptor alpha in breast cancer cell lines
Lhota, Filip ; Kleibl, Zdeněk (advisor) ; Souček, Pavel (referee)
Filip Lhota: Study of alternatively spliced variants of estrogen receptor alpha in breast cancer cell lines Abstract: Estrogen receptor α (ER-α) is a transcription factor responsible for mediation of the activities of its natural ligand 17-β-estradiol (E2), the hormone that together with progesterone belongs to the key regulators of mammary epithelial as well as breast cancer cells proliferation. Except to the major gene product consisting of all eight coding exons of ER-α, numerous qualitatively and quantitatively different spliced variants originated from primary transcript by activity of alternative splicing is expressed. Despite that some of these spliced variants have been functionally characterized, their precise role on final ER-α cellular activity remains to be elucidated. The functional characterization of individual alternative forms of ER-α and description of its participation on the overall ER-α activity is important for our understanding of their biogenesis and is also critical for the delineation of molecular bases for ER-α regulation during anti cancer chemotherapy. This work aimed to study the influence of alternatively spliced ER-α variants on the growth characteristics of clones constructed from stable mammary tissue cell lines in regulation to cultivation conditions and cellular...
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