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Spectrometry of neutron field based on p(20)+Be source reaction
Kozic, Ján ; Štefánik, Milan
The research deals with a spectrometry of neutron field based on the p(20)+Be source reaction. The p(20)+Be interaction stands for a nuclear reaction where protons accelerated to energy of 20 MeV bombard Be target. Produced neutron field has broad energy distribution up to 18 MeV. The research was carried out at the Nuclear Physics Institute of the Czech Academy of Sciences and was motivated by extension of experimental possibilities of the NG-2 target station. To determine the neutron spectrum, the activation foil technique was used. During the experiment, ten activation foils were irradiated. Activated foils were measured using the HPGe detector to determine the reaction rates of observed reactions. The neutron field was simulated in the MCNPX code, and the simulation served as a priori information for the unfolding of the neutron spectrum in the SAND-II code. A determined neutron spectrum is essential for various experiments, e.g., material research, measurements of nuclear data, etc.
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The characterization of the collimated beams of fast neutrons with the CLID detecion system
Ansorge, Martin ; Novák, Jan ; Majerle, Mitja ; Kozic, Ján
A new detection device for the measurements of light ions (p, d, t, α) emitted as the products of the nuclear reactions induced by fast neutrons (5-33 MeV) was recently developed at the Nuclear Physics Institute of the Czech Academy of Sciences. The main objective of the Chamber-for-Light-Ion-Detection (CLID) is to produce new differential nuclear data of high interest for the material applications related to fusion and aerospace technologies and to potentially test and validate models of nuclear reactions. Hereby the experimental set-up for the measurements with the CLID is described in detail. The experimental characterization of the collimated fast neutron beams produced by the cyclotron-driven converter (p(35 MeV)+Be(2.5 mm)) is presented. In particular, the implementation of the Proton-Recoil-Telescope technique used for neutron energy spectra determination with the CLID is described.
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Synthesis of antimicrobial active anilides
Kozic, Ján ; Vinšová, Jarmila (advisor) ; Imramovský, Aleš (referee)
This work is talking about antimycobacterial salicylanilides and their thioxo analogues. In the introduction of this work there is a short review of biological activities of salicylanilides and description of mechanism of their action against bacterials. In details are analysed relationships between the structure and activity. There are compared antibacterial and antimycobacterial modifications of molecule of salicylanilide. The following part of this work brings the synthesis of five salicylanilides, their characteristics and the results of antimycobacterial activity. Unexpected is the relatively high activity of methoxyderivates. There is analysed also the other possibilities of synthesis of salicylanilides. Keywords: salicylanilides, antimycobacterial compounds, antituberculotics activity, relationship between the structure and activity
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Synthesis and Design of Potentially Antibacterial Active Compounds
Kozic, Ján ; Vinšová, Jarmila (advisor) ; Doležal, Martin (referee) ; Hanusek, Jiří (referee)
University: Charles University in Prague Faculty: Faculty of Pharmacy in Hradec Králové Department: Department of Inorganic and Organic Chemistry Candidate: Ing. et Mgr. Ján Kozic Supervisor: Prof. RNDr. Jarmila Vinšová, CSc. Title of Doctoral Thesis: Synthesis and Design of Potentially Antibacterial Active Compounds This work deals with the synthesis of benzanilides and their analogues as the potentially antimycobacterial active compounds. In the theoretical part of the work there is a description of tuberculosis (TBC) as a mycobacterial infectious disease and a short characteristic of recent antituberculotic drugs. The most important features of both, which determine the imperfection of recent antitubeculotics and the long-term multidrug TBC treatment, are emphasised. Further, some of the potential targets, useful for the development of new and more effective antituberculotics, are reviewed. Finally, there is a short overview of biological properties of benzanilides and thiobenzanilides and a more in depth characteristic of stereochemical properties of these compounds. In the experimental part of the work there are presented 100 benzanilide derivatives and their analogues. Ninety-two of these compounds are original, which have not been described in literature yet. For all of the compounds there...
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Synthesis of antimicrobial active anilides
Kozic, Ján ; Imramovský, Aleš (referee) ; Vinšová, Jarmila (advisor)
This work is talking about antimycobacterial salicylanilides and their thioxo analogues. In the introduction of this work there is a short review of biological activities of salicylanilides and description of mechanism of their action against bacterials. In details are analysed relationships between the structure and activity. There are compared antibacterial and antimycobacterial modifications of molecule of salicylanilide. The following part of this work brings the synthesis of five salicylanilides, their characteristics and the results of antimycobacterial activity. Unexpected is the relatively high activity of methoxyderivates. There is analysed also the other possibilities of synthesis of salicylanilides. Keywords: salicylanilides, antimycobacterial compounds, antituberculotics activity, relationship between the structure and activity
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