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Chiral recognition by mass spectrometry
Kosíková, Lenka ; Roithová, Jana (advisor) ; Bednář, Petr (referee)
Title: Chiral recognition by mass spectrometry Author: Bc. Lenka Kosíková Department: Department of Organic Chemistry Supervisor: doc. Mgr. Jana Roithová, Ph.D. This work is focused on the use of mass spectrometry as the analytical method for chiral recognition in the gas phase. We have examined formation of complexes (S and R) isomers [dimethyl-2,2'-dihydroxy-1,1'binaphthalene-3,3'-dicarboxylate] with sodium. Chiral effect for the fomation of sodium dimers is 1,34±0,06 and that for formation of trimers 2,38±0,22 in favor of the formation of homochiral complexes. Part of the work is devoted to the preparation of isotopically labeled ester [(R)-(−)- di(D3-methyl)-2,2'-dihydroxy-1,1'binaphthalene-3,3'-dicarboxylate]. Mixing of equimolar amounts of D3-(R) and unlabeled (S) isomers leads to the artificial racemate, while we can still distinguish the enantiomers using mass spectrometry. Another part represents the study of the complex formation between (S and R) isomers of [dimethyl-2,2'-dihydroxy-1,1'binaphthalene-3,3'-dicarboxylate] with the metal complex [(S,S)-1,5-diaza-cis-decalin]Cu(OH)I depending on the molar ratios in the solution. I have showed that the molar concetration of the catalyst in the solution plays an important role in the complex formation and that the ESI source spectra of...
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Project management in a selected corporation
Košíková, Lenka ; Švecová, Lenka (advisor) ; Tóthová, Lucia (referee)
The aim of the dissertation is to analyze the project management processes in a specific corporation from the point of view of a selected department. The introduction is dedicated to a closer view on the definition of the project. The following section, the presentation of the individual methodologies -- IPMA, PMBoK and PRINCE2 along with their comparison, is a knowledge-based input for the practical section. The introduction of the practical section focuses on the explanation of the project's origin, its scope and benefits. The project management is subsequently described within its life cycle. Each phase is concluded with a short chapter which summarizes the monitored process and contains a recommendation for improvements in the company's management. The conclusion is a personal summary of the project operation as it is and the project management in the selected department along with major points that would be convenient to implement.
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