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Chronic vulvovaginal discomfort and quality of vaginal environment
Kestřánek, Jan ; Špaček, Jiří (advisor) ; Unzeitig, Vít (referee) ; Hořejší, Jan (referee)
"Chronic vulvovaginal discomfort and quality of vaginal enviroment" Vulvovaginal discomfort (VVD) is not a life-threatening disease, however, its impact on quality of life is enormous. The causes of the origins of the chronic form are not provably clarified. OBJECTIVES OF THE THESIS: The first aim of this thesis has been to make an attempt to reveal the etiology of chronic vulvovaginal discomfort (CVD), to characterize a group of patients with CVD and refer it to the quality of vaginal environment. The second aim has been an evaluation of a questionnaire, which had been focused on probable causal factors of CVD. The third part is experimental, focused on the issue of quorum sensing molecule (QSM) and manosa-binding lectin (MBL) polymofrisms. METHODS: The data for all three parts of the study were gained at the outpatient's department for CVD by examinig and following CVD patients. A questionnaire was used when investigating the probable CVD factors. RESULTS: The study has proved that we come across the idiopatic form of CVD in most cases. According to the results, the issue concerns mainly women at productive age, in most cases healthy, without an evident trigger moment. The study has also shown that the most noticeable finding in CVD patients is an absence of lactobacillus proved when performing a...
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Metabolic aspects of the hormone replacement therapy in menopause
Fait, Tomáš ; Cibula, David (advisor) ; Češka, Richard (referee) ; Hořejší, Jan (referee)
The aim of project was to evaluate which of aplication forms of estrogen replacement therapy (in daily doses 2 mg estradiol orally or 0,05 mg estradiol transderma) is better for postmenopausal women from the view of cardiovascular risk. Oral aplication was conected with favourable elevation of HDL-cholesterol level and lowering of prothrombin activator inhibitor (PAI-1). On the other side there were elevation of tigylcerides and high selective C-reactive protein (hs CRP) and lowering of tissue factor pathway inhibitor (TFPI). Transdermal therapy was conjoined with elevation of HDL-cholesterol. Other markers were not influenced by this aplication form. Transdermal estrogen replacement therapy is more favourable than oral estrogen replacement therapy from the view of cardiovascular risks. The choice of hormone replacement therapy must be strongly individual. The knowledge of level lipids and other factors of cardivascular risk, could be helpfull during choice of aplication form, dose and contents of hormone replacement therapy.
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Autoimmune ovarian damage in adolescent girls, the impact antiovarian antibodies to irregular menstrual cycles and fertility
Kosová, Hana ; Hořejší, Jan (advisor) ; Grim, Miloš (referee) ; Fučíková, Terezie (referee) ; Ulčová-Gallová, Zdeňka (referee)
pou~i II "Iaylnr madt: Ihcra ", ledy pouá\ <iní malých, kontrolm':lné individuálních djvek lmg"nú. mbJcuovaných po I. ji ~ li:' lIf pOLdní pl'<Jlilerac \ honnonálni fun kč n í cytol(lgii rroge~lt:rnnCIl1 O ú...pé hu na~ í terapie jsme se pfcw~ dč iJi pn detekl: hladin) antio\'ariálních protilmek. kdy Isme v 40. 16 r l<unamell"li ...níLení a u J ().9~'k pac'ientck ymiLenl protiljtek. lento rakt je Jol ,zen i tim. ze u , ě l šiny paci nt k pi'i této terapii se objekt i vně I.lcpšil ,tav vnitr'ních rodidel, seKundární h p0hlavn ích znakú . Za zcela zjsadoí PO\ 37Ukjc "Ol/čas né Lkpšení koslní d' n, i t~" 8, SHRNUTÍ );,Iedky naší studie a mapování výskytu sérových anlio\'ari:ílních prulil51c:k mis vcde k přesvědče n í. ze výskyt autoprotilátek proli ovariu kore<;pondujc , dříve č i pOldiíji ,e prclcntu jícími klinickými přízn ak y . On ' mocnění múže propuknou v obdohí od puherty po celé reprod u kč ní období. Zavedení adekvátní léč by (v na' i studi i s ' osvědčilo použití HRT) podle našich poznatku vedlo ke snížení autoimunního ro ~ kole ní ovaria na minimum, k L:lchování jeho hormonáln ích funkcí a pIedevším k zachování zdl'avé ovariální tkáně, n.:Lb)lné pro budoucí rertilitu pacientky. Naše tudie tedy potvrdila nepochyhně obrovsky význam vča s n é diagnostiky a léčb y autoimunitního one muc ně ní uvaria, Z...
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Internet in Cuba and Censorship
Hořejší, Jan ; Veber, Jaromír (advisor) ; Luc, Ladislav (referee)
This paper focuses on issues related to Internet in Cuba, their development, current trends and tendencies and nowadays course of events in the Cuban network also with regard to the United States - Cuban thaw. Further on, the methodology of limiting the access to the open Internet including Internet censorship is explained and the analytical part determines how much freedom of an Internet user in Cuba is actually limited.
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