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Musculoskeletal System Dysfunction in Patients in Long-Term Remission of Wilms Nephroblastoma
Šafářová, Marcela ; Kolář, Pavel (advisor) ; Véle, František (referee) ; Eckschlager, Tomáš (referee)
Musculoskeletal System Dysfunction in Patients in Long-Term Remission of Wilms Nephroblastoma Objective: The objective of this retrospective clinical study was to describe the multidisciplinary program of childhood cancer survivors in their young adult age in an adult-based ambulatory medical setting and to report the latent sequelae of the pathology. The hypothesis is that the treatment with all three modalities (chemotherapy, radiotherapy and surgery) causes the development of the latent effects in varying degrees. The goal of this study was to investigate the typical musculoskeletal system changes of survivors of Wilms Nephroblastoma who had previously received their basic treatment more than 5 years ago. Design: 151 subjects underwent clinical assessment of body posture, postural tests and evaluation on BalanceMaster® force plate. These tests were conducted in conjunction with other clinical evaluations, namely, pulmonary and renal function tests, immunology deficiency and exercise capacity to seek its relationship to the diseases' risk factors. The correlation between postural findings and the above clinical tests were investigated. Subjects: Ambulatory patients with a primary diagnosis of nephroblastoma who have undergone treatment greater than 5 years ago. Settings: Clinics at the University...
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