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The Role of MicroRNAs in the Progression of Cardiovascular Diseases
Černá, Václava ; Pešta, Martin (advisor) ; Vítovec, Jiří (referee) ; Chottová Dvořáková, Magdaléna (referee)
Current applied research of microRNA molecules is focused on the identification of their roles in the pathogenesis of various types of diseases, including cardiovascular (CV), with the assumption of their use as biomarkers or treatment targets. Cardiovascular diseases have a high incidence and prevalence in the population, are predominantly chronic, and are also a leading cause of hospitalization and death, and therefore represent a major burden on patients and the health system. Many metabolic parameters are currently used in the diagnosis of cardiovascular diseases and cardiovascular risk assessment, mostly proteins and lipids, while parameters from the group of nucleic acids, whether in the form of mutations in DNA molecules, or various RNA molecules, are very limited so far. Despite the undeniable importance and contribution of metabolic biomarkers in the diagnosis and prognosis of cardiovascular diseases, these markers still do not allow effective identification of all patients at high risk, and therefore additional molecules are being sought that could contribute to the accuracy of this identification. Finding other potential diagnostic and prognostic markers to contribute to the more precise CV risk assessment, and subsequently also to the more effective treatment of patients at high risk,...
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Reflection on the works of Bronius Radzevičius in Lithuanian literary criticism
Dvořáková, Magdaléna ; Kusá, Mária (advisor) ; Šeferis, Vaidas (referee)
FILOZOFICKÁ FAKULTA UNIVERZITY KARLOVY V PRAZE Ústav východoevropských a slavistických studií Magdaléna Dvořáková REFLEXE DÍLA BRONIUSE RADZEVIČIUSE V LITEVSKÉ LITERÁRNÍ KRITICE Vedoucí: Prof. PhDr. Mária Kusá, CSc. Oponent: Mgr. Vaidas Šeferis, PhD Prohlašuji, že jsem diplomovou práci pouze uvedenou literaturu. vypracovala samostatně a že jsem použila 2 iV I .Z-{U./ Jtw~L,~) ÚVOD LITERÁRNÍ KRITIKA V OBECNĚJšíCH RYSECH 1.1 1.2 1.3 Úvod V. Kubilius: Problém hodnot v kritice Život Broniuse Radzevičiuse 1.4 Literární a mimoliterární kontext tvorby B. Radzevičiuse REFLEXE DÍLA B. RADZEVIČIUSE V LITERÁRNÍ KRITICE 2.1 PRVNÍ KRITIKY 70. LET 2.1.1 3.1 M. Sluckis: Mladí prozaici a současná situace LITERÁRNÍ KRITIKY OSMDESÁTÝCH A POZDĚJšíCH LET 4 6 7 10 13 15 17 20 3.1.1 R. Šilbajoris: B. Radzevičius v detailu, světle, smrti 23 3.1.2 S. Žukas: Člověk ve sněhu 26 3.1.3 A. Zalatorius: O lidskosti v novelách B. Radzevičiuse 33 3.1.4 R. Braženaite: Hledání ztraceného času 37 3.1.5 S. Žukas: O vztahu tvorby Broniuse Radzevičiuse s biliunaskou tradicí 42 3.1.6 J. Spindyte: Lyrika v současné litevské próze 49 3.1.7 L. Gutauskas: O hodnotě románu Priešaušrio vieškeliai 51 3.1.8 V. Kelertiene: Metafyzika svítání 52 3.1.9 A. Nyka-Niliunas: Fragmenty z deníku. 1971 - 1998 53 4.1 FILOZOFICKÉ STATĚ 4.1.1 A. Šliogeris:...
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Morphology of the Křížový potok river channel in the Eastern Krkonoše Mountains
Dvořáková, Magdalena ; Engel, Zbyněk (advisor) ; Kliment, Zdeněk (referee)
This master thesis deals with the morphology of mountain river channels - with structures, patterns and shapes resulting from fluvial processes. The findings are documented on the Křížový potok river channel in the Eastern Krkonoše mountains. There are several specifics which influence the evolution of mountain river channels. The first one is high elevation change and big slope of the river, which determinate the formation of typical structures, such as waterfalls, cascades and steps, often related with pools. Plane bed, riffle-pool and dune-ripple also represent typical structures of mountain river channels. Specific microstructures are represented by potholes. River channels in forested mountain basins are affected by logs and wood debris, which create local barriers where fine-grained material accumulates. In the Křížový potok river channel, a high diversity of the channel structures can be seen. The most common structures are step-pools and cascades. The stream is influenced by large accumulation of delluvial sediments and wood debris which create obstacles to the flow.
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Study of morphological and functional alternations of autonomic cardiac and vessels innervation and its causes in chronic diseases
Mistrová, Eliška ; Chottová Dvořáková, Magdaléna (advisor) ; Vančura, Vlastimil (referee) ; Adamcová, Michaela (referee)
Within the span of few decades, there has been a significant increase in diabetes mellitus and chronic stress in developed countries, such as the Czech Republic. These conditions have a significant negative effect on physical and mental health. Repeated and long-term exposure to raised levels of glucose, overactivity of the sympathetic nervous system and the increase in plasma levels of stress hormones affects most of the organs in the body, including the heart. The cardiovascular system is regulated by a broad number of neurotransmitters, hormones and neuropeptides. Alterations in the innervation of the cardiovascular system, as a result of both diseases, can affect its physiological functions. The present thesis focuses not only on the role of the classic, but primarily on the peptidergic innervation of the heart. The aim was to contribute to the explanation of the impact of neuropeptides and their shared receptor systems on the genesis and the development of heart damage due to diabetes mellitus and/or exposure to stressors. Knowledge of the physiological characteristics of neuropeptides and their involvement in the pathogenesis of both diseases and related complications could be helpful in determining the optimal treatment method or alternatively allow us to use the cardio protective effect of...
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Study of morphological and functional alternations of autonomic cardiac and vessels innervation and its causes in chronic diseases
Mistrová, Eliška ; Chottová Dvořáková, Magdaléna (advisor) ; Vančura, Vlastimil (referee) ; Adamcová, Michaela (referee)
Within the span of few decades, there has been a significant increase in diabetes mellitus and chronic stress in developed countries, such as the Czech Republic. These conditions have a significant negative effect on physical and mental health. Repeated and long-term exposure to raised levels of glucose, overactivity of the sympathetic nervous system and the increase in plasma levels of stress hormones affects most of the organs in the body, including the heart. The cardiovascular system is regulated by a broad number of neurotransmitters, hormones and neuropeptides. Alterations in the innervation of the cardiovascular system, as a result of both diseases, can affect its physiological functions. The present thesis focuses not only on the role of the classic, but primarily on the peptidergic innervation of the heart. The aim was to contribute to the explanation of the impact of neuropeptides and their shared receptor systems on the genesis and the development of heart damage due to diabetes mellitus and/or exposure to stressors. Knowledge of the physiological characteristics of neuropeptides and their involvement in the pathogenesis of both diseases and related complications could be helpful in determining the optimal treatment method or alternatively allow us to use the cardio protective effect of...
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New Options of Social Inclusion and Prevention of Recurrence of Criminal Offenders
Dvořáková, Magdalena ; Arnoldová, Anna (advisor) ; Jelínek, Jiří (referee)
Trend of declining crime rates in recent years, on the other hand rising recidivism raises many questions for the existing criminal justice system. High return to prison gives the impression that the purpose of a sentence of custodial sentence lose at the beginning of the third millennium its meaning. The challenge not only for the state apparatus, but the whole society is more than ever becoming reintegration of offenders, which is a predictor of risk of recidivism. The aim of this thesis is therefore description and evaluation aspects of the process of social reintegration, taking into account current possibilities to prevent reoffending. Empirical part extends the intention of re-socialization efforts charting selection of innovative programs in social work with offenders. Theoretical material consists of key concepts weighing the Criminology and Penology, which is completed at the end of work formulating recommendations for social work with offenders as a possible guide changes in the life of each individual offender.
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