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Comparison of Leoncavallo’s and Puccini’s opera La Bohéme
Škandera, Adam ; DOLEŽAL, Vladimír (advisor) ; MELNIK, Natalija (referee)
Bachelor thesis focuses on important figures of the great opera world of the 19th and 20th centuries, Giacomo Puccini and Rugger Leoncavallo. It focuses on the life of both composers and a summary of their opera works. Great emphasis is placed above all on La Bohéme opera, which the two composers wrote almost simultaneously. The work describes the story of both of Bohém, which, although written on the same subject of the novel by Henry Murger Scènes de la Vie de Boheme, are different and each highlights the other components of the story.
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Working on the character of Aljeja in the opera From the house of dead
Bragagnolo, Michal ; HAJÓSSYOVÁ, Magdaléna (advisor) ; DOLEŽAL, Vladimír (referee)
This Master´s thesis titled „Working on the character of Aljeja in opera From the house of the dead is intended to familiarize the reader with the author´s work on the role – play in the staging of the opera From the house of the dead. It also shows the reader how such preparation of the singer should ideally look like.
The autor focuses on Leoš Janáček and also on circumstances that influenced his work. The author also describes the whole proces of rehearsing – singing staging, stage rehearsing and rigours of this creative proces.
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THE COMPARISON OF TWO WORLD-CLASSES THEATERS WITH FOCUS ON ITS OPERA STUDIOS
Hořejšová, Tereza ; DOLEŽAL, Vladimír (advisor) ; HAJÓSSYOVÁ, Magdaléna (referee)
This work compares two of the biggest opera houses – La Scala and the Metropolitan opera New York and focuses on its Opera Studios. The main goal is to collect as many information as possible and to get to know which one of these institutions provides better possibilities for beggining singers. Besides finding new information I have used my connections with current participants in these institutions, so I could compare their experiences with mine. I have found out two ways of getting into opera studios in general and got to a conclusion which one is more efficient for me personally. Besides practical tips, this work includes historical facts as well as data on notable operatic performers. My thesis should be primarily useful for singers who aspire to have an international carreer.
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Healthy lifestyle in the educational reality of a selected schoo
Doležal, Vladimír ; Čevela, Rostislav (advisor) ; Kovaříková, Miroslava (referee)
TITLE: Healthy lifestyle in the educational reality of a selected school AUTHOR: Vladimír Doležal DEPARTMENT: Department of Education SUPERVISOR: MUDr. Bc. Rostislav Čevela, Ph.D. ABSTRACT: This diploma thesis deals with the education and healthy lifestyle in the category of teenagers. The aim of the diploma thesis is to map out the important issues that affect the lifestyles of teenagers, mainly in relation to the secondary school environment, school documents, such as ŠVP, RVP and the effects of high-risk behavior. The diploma thesis also focuses on the important aspect of this topic, the interaction teacher - pupil, the aim of this section is to document and analyze whether the students perceive their teacher's approach to a healthy lifestyle and whether it's something that personally affects them. The current approaches to the education and healthy lifestyle in the secondary school environment are documented and analyzed in the diploma thesis. A brief excursion into the history of these key concepts is also included in the diploma thesis. KEYWORDS: Education, lifestyle, high school, student, teacher, ICT.
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Education impacts on the health of teenagers and teaching of mathematics
Doležal, Vladimír ; Čevela, Rostislav (advisor) ; Kovaříková, Miroslava (referee)
TITLE: Theimpatofeducation on healthofteenagers and teachingofmathematics AUTHOR: Vladimír Doležal DEPARTMENT: Department of Education SUPERVISOR: MUDr. Bc. Rostislav Čevela, Ph.D. ABSTRACT: This diploma thesis deals with the education and healthy lifestyle in the category of teenagers. The aim of the diploma thesis is to map out the important issues that affect the lifestyles of teenagers, mainly in relation to the secondary school environment, school documents, such as ŠVP, RVP, high-risk behavior and the influence of subcultures. The special topic of this diploma thesis is to analyze the teaching mathematics at a particular secondary school related to the healthy lifestyles of the current student's population. The diploma thesis also focuses on the important aspect of this topic, the interaction teacher - pupil, the aim of this section is to document and analyze whether the students perceive their teacher's approach to a healthy lifestyle and whether it's something that personally affects them. The current approaches to the education and healthy lifestyle in the secondary school environment are documented and analyzed in the diploma thesis. A brief excursion into the history of these key concepts is also included in the diploma thesis. KEYWORDS: Education, lifestyle, subcultures, high school, student,...
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The role of charged residues in the activation and modulation of the TRPA1 ion channel
Zímová, Lucie ; Vlachová, Viktorie (advisor) ; Doležal, Vladimír (referee) ; Rokyta, Richard (referee)
Important receptor for sensing painful stimuli is ion channel TRPA1, which is expressed in peripheral endings of nociceptive neurons, where it serves as transducer of physical and chemical environmental signals to the language of the nervous system. The effort to understand the mechanisms of its activity on a molecular level is driven by the vision of progress in treatment of chronic pain in humans. Our work focused on C-terminal cytoplasmic domain of TRPA1 receptor, where we described i.a. the probable binding site for calcium, which is the most important TRPA1 modulator. Using the combination of homology modeling and molecular dynamic simulations with electrophysiological measurements we were able to explain molecular basis of familial pain syndrome caused by TRPA1 point mutation. We contributed to the understanding of the TRPA1 voltage-dependent activation mechanism by describing the amino acids in proximal C-terminus and in S4-S5 linker of transmembrane domain that are directly involved in voltage-dependent gating. Powered by TCPDF (www.tcpdf.org)
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Activation mechanisms of muscarinic M1 receptor by atypical agonists
Randáková, Alena ; Doležal, Vladimír (advisor) ; Mysliveček, Jaromír (referee) ; Krůšek, Jan (referee)
Atypical agonists of muscarinic receptors bind to individual receptor subtypes with comparable affinity but activate them selectively to a certain extent. Molecular mechanism underlying this "functional selectivity" is not known and its elucidation may contribute to development of new atypical functionally selective agonists suitable for therapeutic use. Functional selectivity of atypical muscarinic agonists may be caused by a distinct molecular mechanism(s) of how these compounds activate the receptor. Agonist-specific conformations induced by structurally complex atypical agonists may lead to utilization of a parallel activation mechanism that is different than the activation mechanism induced by non-selective classical agonists. In order to examine this possibility we investigated whether the M1 receptor preferring atypical agonists xanomeline and N-desmethylclozapine, and the classical orthosteric agonists carbachol and oxotremorine, activate the M1 receptor through a common cascade of transmission switches. To this end we mutated key amino acids of the M1 receptor that are essential for ligand binding to the orthosteric binding site (D1053.32 , D993.26 ), receptor activation (transmission switch, D712.50 ), or interaction with G-protein (ionic lock switch, R1233.50 D1223.49 ). We compared...
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Mechanisms of signal transduction via the muscarinic receptors
Dolejší, Eva ; Doležal, Vladimír (advisor) ; Kršiak, Miloslav (referee) ; Vlachová, Viktorie (referee)
Muscarinic acetylcholine receptors (mAChR) belong to the family of G-protein coupled receptors. There are five subtypes of mAChR denoted M1 to M5 that are widely and differentially distributed in both the central nervous system and periphery and play an important role in many specific physiological functions. Impairment of muscarinic neurotransmission occurs in serious disorders such as Alzheimer's disease, schizophrenia or Parkinson's disease that are accompanied by cognitive decline mainly due to the disruption of M1 receptor signaling in the brain. Unfortunately, the high degree homology of the orthosteric binding site among muscarinic receptor subtypes makes it very difficult to obtain subtype- selective agonists. One of the few known selective agonists is xanomeline that preferentially activates the M1 and M4 subtypes. Xanomeline exerts unique interactions with muscarinic receptors comprising reversible binding to the orthosteric domain, and wash-resistant allosteric interaction with a secondary binding site. The basis of xanomeline functional selectivity remains largely unknown. In an attempt to probe into such mechanisms we investigated the immediate and long-term effects of xanomeline on activation of muscarinic receptors, using intact Chinese hamster ovary (CHO) cells expressing individual...
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