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National Repository of Grey Literature

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	Imunologické aspekty rozvoje kolorektálního karcinomu na bezmikrobních modelech Vannucci, Luca ; Štěpánková, Renata ; Pospíšil, Miloslav ; Kozáková, Hana ; Tlaskalová, Helena ; Kuldová, Markéta ; Fišerová, Anna Our data support the finding that mild chronic inflammation sustained by commensal flora in the bowel of conventional animals may be the cause of an effective anticancer response by both mucosal and general immunity Detailed record
	Imunologické aspekty rozvoje kolorektálního karcinomu na bezmikrobních modelech Vannucci, Luca ; Štěpánková, Renata ; Kozáková, Hana ; Tlaskalová, Helena ; Fišerová, Anna ; Pospíšil, Miloslav Our data support the findings that mild chronic inflammation (“physiologic inflammation”) sustained by commensal flora in the bowel of conventional animals may be the cause of an effective anticancer response by both mucosal and general immunity Detailed record
	Involvement of NK1.1 receptor in GlcNAc8-conjugate in regulation of antibody formation Huliková, Katarína ; Pospíšil, Miloslav ; Svoboda, Jan ; Kuldová, Markéta ; Fišerová, Anna GlcNAc8-glycoconjugates modulates antigen presentation and B lymphocytes antibody production through NK1.1 receptor triggering Detailed record
	Toll-like receptors -2, -4 and the CD14 molecule in intestinal biopsies of patients with nonspecific intestinal inflammation Frolová, Lenka ; Drastich, P. ; Klimešová, Klára ; Rossmann, Pavel ; Tlaskalová, Helena Expression of TL-2 and TL-4 receptors and of their transmembranes coreceptor CD14 was detected immunohistochemically in biopsies of ileum, colon caecum and rectum of patients suffering from ulcerous colitis or Crohn´s disease. All these three were significantly enhanced in epithelial cells and macrophages of propria in inflammatory bowel disease as compared to the control samples Detailed record
	Multivalentní glykokonjugáty ve studiu interakce lektinových receptorů NK/NKT buněk Vannucci, Luca ; Pospíšil, Miloslav ; Rossmann, Pavel ; Chernyavskiy, Oleksandr ; Kubínová, Lucie ; Křen, Vladimír ; Luptovcová, Martina ; Svoboda, Jan ; Kuldová, Markéta ; Bezouška, Karel ; Fišerová, Anna The events following the administration of GN8 in vitro, in vivo and ex vivo, lead to increased expression of CD69. The CD69-dependent IFNg production is modulated by co-activation of NKG2D and Ly49 receptors. Glycodendrimers can assist the dissection of activation network of NK/NKT cell lectin-like receptors in rat and murine models Detailed record
	Multivalentní glykomika v imunoterapii experimentálních nádorů Vannucci, Luca ; Pospíšil, Miloslav ; Krist, Pavel ; Křen, Vladimír ; Huliková, Katarína ; Luptovcová, Martina ; Svoboda, Jan ; Kuldová, Markéta ; Bezouška, Karel ; Rossmann, Pavel ; Difato, Francesco ; Mosca, F. ; Fišerová, Anna Lectin-like receptors can modulate the cytotoxic, regulatory and dendritic cell responses by their interactions. GN8 multivalent glycoconjugates are able to internalize inside and activate NKR-P1 positive cells inducing production of IFN-gamma and expression of CD69. The final effect is a modulation of anticancer immunity with reduction of cancer growth Detailed record
	Rozvoj kolorektálního karcinomu u konvenčních a bezmikrobních potkanů: imunologické a enzymatické aspekty Vannucci, Luca ; Štěpánková, Renata ; Pospíšil, Miloslav ; Kozáková, Hana ; Tlaskalová, Helena ; Kuldová, Markéta ; Fišerová, Anna Environmental conditions cooperate to colorectal carcinogenesis. In an experimental model in the rat was evaluated the impact of the commensal intestinal flora on cancer development, and consequent general variations of the immunity, versus germ-free (GF) conditions. Less and smaller tumors developed in GF rats and a better developed immune response appeared to be able to be elicited in absence of intestinal bacteria Detailed record

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