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National Repository of Grey Literature

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	Imunologické aspekty rozvoje kolorektálního karcinomu na bezmikrobních modelech Vannucci, Luca ; Štěpánková, Renata ; Pospíšil, Miloslav ; Kozáková, Hana ; Tlaskalová, Helena ; Kuldová, Markéta ; Fišerová, Anna Our data support the finding that mild chronic inflammation sustained by commensal flora in the bowel of conventional animals may be the cause of an effective anticancer response by both mucosal and general immunity Detailed record
	Imunologické aspekty rozvoje kolorektálního karcinomu na bezmikrobních modelech Vannucci, Luca ; Štěpánková, Renata ; Kozáková, Hana ; Tlaskalová, Helena ; Fišerová, Anna ; Pospíšil, Miloslav Our data support the findings that mild chronic inflammation (“physiologic inflammation”) sustained by commensal flora in the bowel of conventional animals may be the cause of an effective anticancer response by both mucosal and general immunity Detailed record
	Interakce glycodendrimérů s nádorovým mikroprostředím Pospíšil, Miloslav ; Vannucci, Luca ; Luptovcová, Martina ; Svoboda, Jan ; Huliková, Katarína ; Kuldová, Miloslava ; Bezouška, Karel ; Krist, Pavel ; Pešta, M. ; Fišerová, Anna Potentiation of immunological parameters by multivalent glycodendrimers (PAMAM-GlcNAc8) against experimental mouse melanoma and rat colon or glioma cancer. PAMAM –GlcNAc8 induce biological effects at different levels of cancer microenvironmental components and concern both, effector and cancer cells Detailed record
	High affinity ligands for human lymphocyte receptor CD69 Pavlíček, J. ; Ettrich, R. ; Novák, Petr ; Man, Petr ; Vodrážková, J. ; Bezouška, Karel CD69 is one of very important activating receptors expressed on the surface of human lymphocytes. Detailed record
	Imunomodulační glykodendrimery mají afinitu k endoteliím nádorových a embryonálních cév. Mikroskopické průkazy a perspektivy využití Vannucci, Luca ; Fišerová, Anna ; Krist, Pavel ; Křen, Vladimír ; Huliková, Katarína ; Luptovcová, Martina ; Rossmann, Pavel ; Difato, F. ; Mosca, F. ; Pospíšil, Miloslav Glycodendrimers coated with N-acetyl-glucosamine and labeled with a fluorescent dye demonstrate special tropism to neogenerated endothelia in cancer capillaries. Same distribution was observed by confocal microscopy in the new vessels of rat embryo abdominal wall, as in placenta and yolk sack endothelia. Results suggests the presence of a commun target on evoluting endothelia, the nature of which is under investigation. Detailed record
	Úloha sacharidových struktur v NKR-P1 zprostředkované interakci efektorových a cílových buněk Fišerová, Anna ; Svoboda, J. ; Kuldová, Markéta ; Pucová, Alexandra ; Bezouška, Karel ; Pesta, M. ; Vannucci, Luca ; Pospíšil, Miloslav Masking oligosaccharide sequences can assist transformed cells to escape immune surveillance. N-acetyl-glucosamine coated dendrimers have binding affinity for NKR-P1 receptor and can also modify cancer cell glycosylation profile. Effects of treatment on immune cell subpopulations were analyzed in blood, lymphoid tissues and organs, and inside tumor in B16F10 melanoma bearing mice. Treatment enhanced tumor cell immunogenicity, and induced maturation,differentiation and homing of cytotoxic cells to tumor microenvironment. Detailed record

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