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National Repository of Grey Literature

63 records found  54 - 63  jump to record:

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	T-cell response in C57BL/10 mice producing low levels of IgG antibody Šírová, Milada ; Říha, Ivan ; Říhová, Blanka Detailed record
	Antibody response of BCGČr and BCGČs mice Hovorka, Ondřej ; Říhová, Blanka ; Skamene, E. ; Šírová, Milada Detailed record
	Využití protilátek pro in vivo diagnostiku a terapii Říhová, Blanka ; Ulbrich, Karel Detailed record
	T buňky mají zásadní úlohu při vytvoření protinádorové imunity u myší léčených protilátkou směrovanými konjugáty doxorubicinu a HPMA Mrkvan, Tomáš ; Kovář, Marek ; Etrych, Tomáš ; Strohalm, Jiří ; Plocová, Daniela ; Ulbrich, Karel ; Říhová, Blanka Anti-idiotype monoclonal antibody targeted N-(2-hydroxypropyl)methacrylamide copolymer bound doxorubicin is able to completely cure mice with BCL-1 B-cell leukemia. During the treatment the immune system is activated and effective long-term anti-tumor immunity is established. This immune reaction requires CD4+ and CD8+ cells. Detailed record
	Antracyklinová antibiotika na bázi protilátkou směrovaného HPMA Říhová, Blanka ; Strohalm, Jiří ; Jelínková-Ibrahimová, Markéta ; Kovář, Marek ; Šubr, Vladimír ; Etrych, Tomáš ; Mrkvan, Tomáš ; Šťastný, Marek ; Plocová, Daniela ; Šírová, Milada ; Hovorka, Ondřej ; Kubáčková, K. ; Ulbrich, Karel Conjugates based on N-(2-hydroxypropyl)methacrylamide represent a new generation of polymeric anticancer drugs with improved therapeutic potential and considerably decreased nonspecific side effects. Antibody -targeted derivatives show specific active targeting and nonspecific passive accumulation in solid tumors. Detailed record
	Exprese genů pro signalizaci apoptozy u buněk vystavených účinku HPMA konjugátů doxorubicinu Kovář, Lubomír ; Kovář, Marek ; Šťastný, Marek ; Strohalm, Jiří ; Etrych, Tomáš ; Ulbrich, Karel ; Říhová, Blanka We compared influence of hydrolytically and enzymatically cleavable conjugates based on N-(2-hydroxypropyl)methacrylamide on proliferatin activity and expression of mRNA of genes involved in apoptotic signalling pathway. We found elevated expression of Fas and bax mRNA in cells incubated with hydrolytically cleavable conjugates. Detailed record
	Mechanismus působení polymerních léčiv na bázi HPMA Hovorka, Ondřej ; Strohalm, Jiří ; Bouček, Jan ; Etrych, Tomáš ; Šubr, Vladimír ; Ulbrich, Karel ; Říhová, Blanka However cytostatic polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide are in clinical trials, we are still far away from understanding the mechanism of their action. Cleavability of the drug from oligopeptidic side-chains of polymeric carriers seems not to be necessary condition for pharmacological activity and those spacers play most probably a very important role in the accumulation of conjugates in tumor cells. Detailed record
	Protinádorová směrovaná léčba na bázi HPMA: základní principy pro syntézu konjugátů a převod z laboratoře do kliniky Říhová, Blanka ; Strohalm, Jiří ; Prausová, J. ; Kubáčková, K. ; Jelínková, Markéta ; Rozprimová, L. ; Šírová, Milada ; Plocová, Daniela ; Etrych, Tomáš ; Šubr, Vladimír ; Mrkvan, Tomáš ; Kovář, Marek ; Ulbrich, Karel Conjugates of N-(2-hydroxypropyl)methacrylamide with doxorubicin containing human IVIg were used for palliative treatment in patients with advanced cancer. More thena 116 biochemical and immunological parameters were tested. A decrease of some parameters with patological values was seen, and physiological values were occasionally reached, including some TAA. Detailed record
	Směrovaná polymerní léčiva Říhová, Blanka Unwanted side effect of anticancer treatment could be eliminated by affinity therapy. It is necessary to find targeting system which deliver drugs specifically to tumor site. Polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide are new generation polymeric anti-cancer drugs with enhanced cytostatic activity, but minimalized unwanted side effects. Detailed record
	Polymerní protirakovinná léčiva s pH- a enzymaticky závislou aktivací Etrych, Tomáš ; Chytil, Petr ; Strohalm, Jiří ; Jelínková, Markéta ; Kovář, Marek ; Říhová, Blanka ; Ulbrich, Karel Water-soluble synthetic polymers and their conjugates with antibodies, oligopeptides or saccharides proved a potential targetable drug delivery system. Recently, copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) have been developed in our laboratory as polymeric carriers of drugs. Detailed record

National Repository of Grey Literature : 63 records found   54 - 63  jump to record:

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15	Říhová, Barbora

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