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Optimization of allergic asthma model in rats
Radová, Hana ; Pourová, Jana (advisor) ; Vopršalová, Marie (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Mgr. Hana Radová ABSTRACT (thesis towards the PharmDr. degree) Optimization of allergic asthma model in laboratory rat The aim of this thesis was the optimization of allergic asthma model in laboratory rats as experimental animals. More specifically, based on the determination/quantification of the number of cells (neutrophils, eosinophils, macrophages and lymphocytes) in bronchoalveolar lavage of Wistar rats, we attempted to determine the optimal time interval (1 hour or 24 hours) needed for the manifestation of an adequate allergic reaction after antigen challenge. Subsequently, we compared Wistar rats with Brown Norway rats over this time interval, and more parameters in Brown Norway rats were examined, specifically the level of eosinophil peroxidase and proteins in bronchoalveolar lavage fluid. We evaluated the induction of the tested model in comparison with non-allergic animals. In conclusion, (1) the time interval of 24 hours after the antigen challenge is more appropriate for the assessment of the selected model of allergic asthma; the time of one hour was not sufficient for the development of the allergic reaction. (2) Considering all evaluated parameters, Brown Norway rats are more suitable...
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The Memory of the Lost Cause and White Southern Nationalism: Case Study of the League of the South
Radová, Hana ; Pondělíček, Jiří (advisor) ; Kýrová, Lucie (referee)
Following the end of the Civil War, the revisionist myth of the Lost Cause spread over the South as an apologist narrative for white hegemony and slavery, which protected the former Confederate states from the devastating effects of their loss. Pro-Confederate organizations lobbied to replace real history with this collective memory of the South through education and memorialization. This national myth then served as a legitimization of white Southern nationalism that sought to restore white hegemony of the antebellum racial order. The white nationalist organization League of the South, whose goal is the second secession of the Southern states, embraces and manifests the ideology of the Lost Cause in its textual and audiovisual discourse and use of iconography. This discourse anchors their separatist intentions in the context of postwar collective memory, and aids the organization in the legitimization of their actions on the basis of revisionist history. The League derives its identity from this collective memory as the self-established white Southern ethnicity of Anglo-Celtic origin and the descendants of Founding Fathers as well as Confederate leaders. In doing so, the League identifies itself as the organization of true heirs of America stigmatized by the external aggression of the federal...
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The transformations of graphic design of ABC magazine from 1989 till 2005
Řádová, Hana ; Slanec, Jaroslav (advisor) ; Láb, Filip (referee)
The topic of this bachelory thesis is progress of graphic design of ABC magazine from 1989. First chapters explain the importance of graphic design and principles of visual incidence at readers and expecially child`s reader. Two chapters describes history of ABC magazine and technological progress in creation of graphic design of ABC. Last part reports basic components of graphic design and concerns changes of this components in ABC.
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A critical analysis of the male protagonists in the Brontë sisters' novels
Radová, Hana ; Beran, Zdeněk (advisor) ; Nováková, Soňa (referee)
Thesis abstract The novels of the Brontë sisters share numerous aspects: defiant heroines, male protagonists as the source of the central conflict, 1st-person layered narrative structure, historical settings, and a redeemed morality as the solution to distortion of harmony. Notably, the authors employ the novel as a medium through which they explore not only the themes of individual ethics, but also the possibilities of female self-realization in a society dominated by patriarchy. The authors' incorporation of the Byronic hero as a principle of destruction into their narratives accentuates the typically Victorian concept of doubt and self-searching not only in their male protagonists, but also in their heroines. Therefore, the male protagonists as the representatives of male dominance are crucial in understanding the development of the Brontës' individual narratives. This thesis attempts to analyse three male protagonists of the Brontës' greatest novels: Heathcliff of Wuthering Heights, Edward Fairfax Rochester of Jane Eyre, and Arthur Huntingdon of The Tenant of Wildfell Hall. Heathcliff's foreign origin brings conflict into the moorland microcosm since his character's first arrival. The destruction of his union with Catherine Earnshaw drives Heathcliff to transgress the social sphere in order to...
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Optimization of allergic asthma model in rats
Radová, Hana ; Pourová, Jana (advisor) ; Vopršalová, Marie (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Mgr. Hana Radová ABSTRACT (thesis towards the PharmDr. degree) Optimization of allergic asthma model in laboratory rat The aim of this thesis was the optimization of allergic asthma model in laboratory rats as experimental animals. More specifically, based on the determination/quantification of the number of cells (neutrophils, eosinophils, macrophages and lymphocytes) in bronchoalveolar lavage of Wistar rats, we attempted to determine the optimal time interval (1 hour or 24 hours) needed for the manifestation of an adequate allergic reaction after antigen challenge. Subsequently, we compared Wistar rats with Brown Norway rats over this time interval, and more parameters in Brown Norway rats were examined, specifically the level of eosinophil peroxidase and proteins in bronchoalveolar lavage fluid. We evaluated the induction of the tested model in comparison with non-allergic animals. In conclusion, (1) the time interval of 24 hours after the antigen challenge is more appropriate for the assessment of the selected model of allergic asthma; the time of one hour was not sufficient for the development of the allergic reaction. (2) Considering all evaluated parameters, Brown Norway rats are more suitable...
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