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Effect of administration of drugs from the group of statins on the atherogenic process / / in an experimental model of atherosclerosis.
Koutníková, Jitka ; Nachtigal, Petr (advisor) ; Trejtnar, František (referee)
The effects statins administration on atherogenic process in the experimental model of atherosclerosis. Mgr. Jitka Koutníková The aim of this rigorous work was to detect and quantify the changes of endothelial expression of VCAM - 1 (the marker of endothelial dysfunction) and endoglin (the marker of angiogenesis) in vessel wall of apoE deficient mice. Endoglin is a part of the receptor complex of the transformation growing factor beta (TGF - beta). Statins are the most considerable substances for the treatment of hyperlipidemia and blood - vessel complications (atherosclerosis). Statins decrease levels of LDL cholesterol and also of triglycerides. Moreover, pleiotropic effects take important part in statin's benefit: the decrease of activity of inflammatory and prothrombotic processes. We used apoE deficient mice as the model of atherosclerosis, fed by standard laboratory diet. We analyzed the levels of total cholesterol in blood and we observed expression of VCAM - 1 and endoglin in aortic sinus and part of aortic arch in all mice. Total cholesterol concentrations were assessed enzymatically by conventional diagnostic methods and spectrophotometric analyses. To display VCAM-1 and endoglin expression in aortic sinus and part of aortic arch we used imunohistochemical methods and for quantification of VCAM-1...
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Monitoring antidepressants consumption in pharmacy in 2003-2005
Borská, Anna ; Vopršalová, Marie (advisor) ; Trejtnar, František (referee)
7. SUMMARY 87 The subject of this thesis is the research of medicine consumption in the selected pharmacy. We focused on the quantification of medication consumption between years 2003 - 2005 in Pharmcentrum Budějovická, Prague 4. In theoretical part of our thesis we summarized the recent knowledge and the best recommendation for the curing of depression. Key attributes of the active principles used at pharmacotherapy of depressions are mentioned as well. In the following part we worked with the figures of single medicine annual consumptions gained from the pharmacy software. Using the DDD/ATC system we have computed the total consumption of each individual medicine. We also tried to learn whether there are any differences in prescriptions of various doctors according to their expertise or age. The consumption of antidepressants in Pharmcentrum Budějovická in the years 2003 - 2005 had been permanently increasing. It corresponds with the numbers published by the VZP (General Medical Insurance Company). There is the significantly growing consumption of so called 3rd generation antidepressants (SSRI) with the most preferred substance Citalopram. With only minor exceptions the consumption of substances of the other new generations has been also increasing. Such trend complies with the recommendations of...
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