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Solid based note-taking application
Horák, Jan ; Klímek, Jakub (advisor) ; Škoda, Petr (referee)
With the ongoing shifting of user-generated content from many independent small websites to several complex web applications run by worldwide commer- cial corporations, the question of data ownership becomes significantly more relevant. This trend has been noticed by sir Timothy Berners-Lee and his team of researchers at the MIT Computer Science & Artificial Intelligence Lab, who introduced Solid, a system for building decentralized social applications, aiming to decentralize power on the web. A web application developed as a part of this thesis aims to contribute to the Solid project by creating a user-friendly note-taking application based on the Solid system. Several methods have been utilized to analyze the requirements and lead the application design and development in the right direction. During and after implementation, the application was thoroughly tested using various approaches. 1
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The influence of PAP phenomenon on performance indicators in sprint from crouch start
Horák, Jan ; Hojka, Vladimír (advisor) ; Šťastný, Petr (referee)
Title: Evaluation of post-activation potentiation effect on performance indicators of sprint following crouch start Objectives: The main objective of this thesis is to evaluate the influence of post- activation potentiation phenomenon on sprinter step performance indicators following crouch start by using Optojump system. Secondary objectives are firstly - to complile systematic up-to-date review based on recently published evidence, and secondly - to compare acquired results with current trends described in this review. Methods: Fifteen (n = 15) moderate to well trained male athletes completed the experimental procol of controlled sprints (20 m), activation of post-activation potentiation / post-activation performance enhancement elicited by series of squats (3 series, 5 repetition, load of 75 % of 1RM, resting interval 2 mins). Following the activation, all participants completed 1x20 m of sprinting performance from crouch start at 5 min, 10 min, 20 min and 40 min. All measurments were made by using the Optojump system. Acquired measurments were further analyzed and statistically evaluated. Results: Evaluation of acquired data did not result in significant positive effect of activation protocol on measured variables. Furthemore, series of squats were associated with decreased peak velocity and...
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Myocardial regeneration after intracoronary injection of autologous bone marrow-derived mononuclear cells in patients with large anterior acute myocardial infarction and late reperfusion
Skalická, Hana ; Horák, Jan (advisor) ; Vojáček, Jan (referee) ; Málek, Ivan (referee)
Myocardial regeneration after intracoronary injection of autologous bone marrow-derived mononuclear cells in patients with large anterior acute myocardial infarction and late reperfusion Objective and background: Despite the use of reperfusion therapies, outcomes in patients with large ST elevation myocardial infarction (STEMI), late reperfusion and left ventricular (LV) dysfunction is poor. We investigated longterm safety and efficacy of intracoronary injections of autologous bone marrow-derived mononuclear cells (BMNCs). Methods: 27 patients with anterior STEMI (age 59 ± 12 yrs, mean baseline LV ejection fraction (LVEF) 39±5%), who underwent percutaneous coronary intervention 4-24 hours after the onset of symptoms, were randomly assigned either to intracoronary BMNCs injection (n = 17, BMNCs group, out of which 14 underwent longterm follow-up), or to standard therapy (n = 10, Control group). The LVEF, the LV end-diastolic and end-systolic volumes (LVEDV, LVESV) and diastolic function (transmitral flow, pulmonary vein flow) were assessed by echocardiography at discharge, month 4 and 24. Myocardial perfusion was assessed using SPECT at baseline and month 4. Results: At 24-month, there was no difference in rates of serious clinical events (36% vs. 50%, p=0,54). At Month 4 LVEF improved to similar extent in...
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Brand Development of the selected Company
Horák, Jan ; Fait, Petr (referee) ; Chlebovský, Vít (advisor)
This master’s thesis analyses a brand of selected company Engineering Test Institute, public enterprise (SZU), which offers services of testing, inspection and certification. Theoretical part of the thesis is focused on literature research of marketing and branding theories. The key part is the analytical part, which contains a detailed analysis of the current state of the brand "Engineering Testing Institute". The thesis also contains a questionnaire survey focused on both the internal environment of the company and its customers. The research is followed by a final part with possible suggestions on how to further develop the brand.
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Documentation of the historical buildings for hops processing: thematic survey of hop dryers
Podroužek, Kamil ; Eismann, Šimon ; Horák, Jan ; Kaláb, Jiří ; Papoušek, Miroslav ; Kuprová, Renata ; Radová, Lucie ; Skalický, David ; Švec, Roman
The main focus of this project NAKI DG16P02B021 Documentation of the historical buildings for hops processing was to perform a basic documentation of the historical buildings for hops processing. These buildings are part of architectual assets bound to the specific natural conditions occuring only in some regions. These conditions constitute an important part of the urbanism of towns and cultural countriside. There has not been given any scientific attention to the development, function, constructions or the technological equipment used on these buildings. In addition, these buildings (except several) are not historically protected. With respect to size, these buildings are of a great financial burden to their owners and have lately been subject to a large scale of demolition. Out of more than 5500 of these buildings listed in the beginning of the 20th century in Zatec hops region itself only hundreds have been preserved. Hence, the documentation is the last possibility of recording these buildings for the future. As part of the basic documentation of the buildings, undoubtful identification, photo-documentation, the documentation of the specific contruction solutions, technological equipment and technological state of proving the hops processing, the land surveying, the construction measurements and sample collection for dendro-chronical dating of selected buildings was performed. The archive research was part of the study as well. Based on this evidence a special map and IISPP/GIS NPÚ based database was created. A highly easy-to-use system was created using sophisticated technology - phones with cameras and GPS modules, tablet PCs, remote network access to the external scanned document storage and remotely accessible GIS and MIS map databases. This system enables operational field documentation and based on this experience a methodology was created that describes the use of this widlely available technology in basic field architectural documentation.
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Sepsis and Sepsis-associated Acute Kidney Injury: Molecular Mechanism and Lovel Aspects of Treatment
Horák, Jan ; Matějovič, Martin (advisor) ; Šrámek, Vladimír (referee) ; Balík, Martin (referee)
Sepsis is the most common cause of death in the intensive care units worldwide. Despite the undeniable progress in pre- and clinical research, the effective causal therapeutic strategy still does not exist. Given to extremely complex and heterogenic host response to presence of infection, the paradigm "one disease, one drug" is obviously flawed and combination of multiple targets that involves early immunomodulation and cellular protection are needed. Cellular therapy using mesenchymal stem cells represents strategy that brought positive results in experiments with rodent septic models. Part of this thesis is dedicated to evaluation of safety and efficacy of stem cells intravenous administration to well-established large animal model of progressive peritoneal sepsis. Affecting of the neuroinflammatory reflex through the vagus nerve stimulation showed potential to attenuate sepsis in rodents. Rest of the text is dedicated to evaluation of vagus nerve stimulation effectivity in our model. KEYWORDS Sepsis, sepsis-associated acute kidney injury, mesenchymal stem cells, vagus nerve stimulation
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Web Editor and Simulator of Logic Gate Networks
Horák, Jan ; Kruliš, Martin (advisor) ; Bulej, Lubomír (referee)
One of the topics taught in computer science is the principles of logic gates. An application that allows students to experiment with logic gates and gate networks can be used as a tool to provide better understanding of the topic. However, in order for the application to be usable, it should be available inde- pendently of the software on the user's computer. As a part of this thesis, we were able to implement such application. It provides users with the function- ality of constructing circuits from logic gates interconnected with wires. The application is able to simulate the network and display logic values on each of the wire. Additional functionality has been provided to make the application more enjoyable - unlimited canvas for circuit construction, a simple tutorial introducing new users to the basics of the application, import and export func- tionality and a library of logic circuits that can be imported onto the editing canvas in the form of gate networks or as single components. The application is easily expandable and the source code is available under an open-source license. 1
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Post-activation potentiation (PAP) phenomenon - review and experimental verification
Horák, Jan ; Hojka, Vladimír (advisor) ; Červinka, Pavel (referee)
Title: Post-activation potentiation (PAP) phenomenon - review and experimental verification Objectives: Firstly, to compile the systematic review of up-to-date literature. Secondly, to develop method using force platform that will be applicable for PAP measurment during the counter-movement jump. Thirdly, to verify PAP by using the developed method in small group of volunteers. Methods: Review part of the thesis was complied according to analysis of up-to-date literature accessible from Charles University electronic system. The data from the analysis were used to develop method for measurment of PAP by using the force platform (Kistler) and activation of PAP phenomenon by series of squats with specific weight. The peak force and rate of force developement were the monitored parameters. This method was applied on a group of volunteers. Results: Results of experimental part of the thesis showed significant changes in monitored parameters and this change is consistent with current literature. Keywords: post-activation potentiation, peak force, rate of force developement, force platform
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