|
Data standard of the health information systems
Krátká, Lucie ; Dvořák, Miroslav (referee) ; Fedra, Petr (advisor)
This work attempts at exploring the data standard of the Ministry of Health of the Czech Republic and the possibilities of access to the hospital information system CLINICOM. At the beginning basic information about data standards in the health care, international classification of diseases and diagnosis related groups are described. The next part is focused at the database platform Caché and possibilities of word wide web access into the system via Caché server pages. Then it describes valid legislature for nation medicine registries and for mandatory reports to the Nation Medicine Registry of Inpatients. In the end of work it describes the realized program in Cache server pages for on-line data message reports about anonym patients into the National Registry of Inpatients. Patients are sort in agreement with time period and diagnosis related groups. Program utility and Internet data transfer security are discussed.
|
|
Intracranial Aneurysms - Treatment Options and Natural Course. Safety and Efficacy of Treatment Strategies for Posterior Inferior Cerebellar Artery Aneurysms.
Petr, Ondřej ; Beneš, Vladimír (advisor) ; Haninec, Pavel (referee) ; Přibáň, Vladimír (referee)
BACKGROUND: Posterior inferior cerebellar artery (PICA) aneurysms are an uncommon, heterogeneous group of aneurysms with poorer neurological outcomes compared to other intracranial aneurysms. At first, as part A, we conducted a systematic review of the literature to evaluate the safety and efficacy of treatment strategies for PICA-aneurysms. Subsequently, as part B, we performed a multicenter retrospective study to analyze the outcome in a large series of patients treated with contemporary microsurgical and endovascular techniques. METHODS: For the meta-analysis, a systematic search of Medline, EMBASE, Scopus and Web of Science was done for studies published through November 2015. We included studies that described treatment of PICA-aneurysms with ≥10 patients. Random-effects meta-analysis was used to pool the following outcomes: complete occlusion, technical success, periprocedural morbidity/mortality, stroke rates, aneurysm recurrence/rebleed, CN-palsies rates, and long-term neurological morbidity/mortality. As the second part, aiming to report the current trends and results in treatment strategies for PICA-aneurysms, records of 94 patients treated for PICA-aneurysms between 2000 and 2015 at 3 large referral neurovascular centers were retrospectively reviewed. RESULTS: In the meta-analysis, we...
|
|
Acipimox during Short-Term Exercise Exerts A Negative Feedback of Growth Hormone on Ghrelin Secretion in Patients with Bulimia Nervosa and in Healthy Women: The Role of Lipolysis
Smitka, Kvido ; Nedvídková, Jara (advisor) ; Kršek, Michal (referee) ; Čáp, Jan (referee)
Title: Acipimox during Short-Term Exercise Exerts A Negative Feedback of Growth Hormone on Ghrelin Secretion in Patients with Bulimia Nervosa and in Healthy Women: The Role of Lipolysis Objective: Eating disorders, such as bulimia nervosa (BN) and anorexia nervosa (AN), are characterized by abnormal eating behavior. The main features of BN are binge-eating and inappropriate compensatory methods to prevent weight gain. The appetite-modulating peptide ghrelin is secreted by the stomach and shows a strong release of growth hormone (GH). A potential GH-ghrelin feedback loop between stomach and the pituitary has been recently reported. Acipimox (Aci), an analogue of nicotinic acid, inhibits lipolysis in adipose tissue (AT) and reduces plasma glycerol and free fatty acids (FFA) levels. Exercise and Aci are stimulators of GH secretion. We suppose that a negative feedback from increased GH levels during exercise may play a role in reducing plasma ghrelin levels. We surmised that altered baseline activity and exercise-induced activation of the sympathetic nervous system (SNS) results in excessive stimulation of lipolysis associated with negative energy balance and may lead to abnormal AT metabolism in patients with BN. Disruption of the gut-brain-AT axis might be involved in the pathogenesis of BN. The...
|
|
Analýza finančních toků spojených se zdravotnictvím a spokojenost pacientů se zdravotní péčí poskytovanou v soukromě vlastněných nemocnicích v České republice
Supová, Aneta ; Štěrbová, Ludmila (advisor)
This Master Thesis focuses on the structure of health related financial flows and patient satisfaction with privately owned hospitals in the Czech Republic. The main aim was to provide a general overview of health care system in the Czech Republic, to describe how the health care system is financed, and to find out if patients hospitalized in privately owned hospitals are more satisfied with the care provided in this type of hospitals. Having analyzed the major statistical reports from the WHO, EU, and the Institution of Health Information and Statistics of the Czech Republic, the theoretical part provided a comprehensive summary of health care, health financial flows, and pricing of health treatments. The practical part, on the other hand, shows distribution of health costs among differently aged people in the form of contribution/expenditure ratio. Finally, the results of the questionnaires conducted among patients in privately owned hospitals enabled to conclude that patients in the Czech Republic are still not fully aware of the difference between privately and publically owned hospitals.
|
|
Computational modelling of human voice propagation through the vocal tract and in space around the head
Švarc, Martin ; Pellant, Karel (referee) ; Švancara, Pavel (advisor)
The following master thesis deals with creating a computational model for acoustic wave distribution by the human vocal tract and then the space around a human head. Detailed mapping of the sound field around the human head is important for more accurate measurement of the human voice. Part of this work is the creation of three-dimensional finite element model of the human head and the vocal tract during phonation of the vowel /:a/ based on the data from the computational tomography. Further the literature search of the function of the vocal tract, biomechanics of the making of the human voice, an overview of the computational models so far published in the literature and in literature reported measurements of the distribution of the human voice by the vocal tract and then in the space around the head . The following is the actual numerical solution of the acoustic waves distribution from the vocal cords through the vocal tract and then the space around the human head when thinking of acoustic absorption on the walls of the vocal tract and on the skin of the head for different types of waking of the model. The results are compared with previously published measurements of the distribution of the human voice and mainly the distortion of the frequency spectra at each specific node in the space around the head and in its vicinity of where the sensor microphones are typically placed are analyzed. Results of the computational modeling will eventually be used for frequency correction for various positions of the microphones scanning the voice distribution in its diagnosis, speech or singing.
|
|
Finalisation of development and verification of Flow123d software within the DECOVALEX 2015 project
Blaheta, Radim ; Maryška, J. ; Březina, J. ; Stebel, J. ; Šembera, J. ; Balvín, A. ; Bruský, I. ; Hasal, Martin ; Michalec, Zdeněk ; Staš, Lubomír ; Sysala, Stanislav
This final report summarizes the progress of work and results for the whole period of the project. The subject is modelling of tasks within the project Decovalex-2015, development of Flow123d software, and preparation of documents for its standardization using the comparison results with foreign teams. TUL team participated in Task C1 (THMC processes in a single fracture) using the software Geochemist’s Workbench and their own tool TrAper for connecting chemistry and deformation and Task C2 (flow and transport in the vicinity of the tunnel Bedřichov) using Flow123d software. Task C2 also includes the formulation of the assignment and coordination of the solution of other teams. The ÚGN team participated in Task A, focusing on saturation of bentonite seals in clay rock and closing the gap, with the help of the COMSOL Multiphysics software. The outputs are the joint report by international teams and papers in a special issue of a journal. The developed models and lessons learned contribute to the ability to predict phenomena in the deep geological repository. Another result is a set of documents for the Flow123d software. All of which are attached to the report as attachments.
|
| |
|
The language of medical reports and its information-lexical analysis
Přečková, Petra ; Zvárová, Jana (advisor) ; Hanzlíček, Petr (referee) ; Skalská, Hana (referee)
The objective of the dissertation thesis has been the information-lexical analysis of Czech medical reports and the usability of international classification systems in the Czech healthcare environment. The analysis of medical reports has been based on the attributes of the Minimal Data Model for Cardiology (MDMC). Narrative medical reports and structured medical reports from the ADAMEK software application have been used. For the thesis SNOMED CT and ICD-10 classification systems have been used. There has been compared how well attributes of MDMC are recorded in narrative and structured medical reports. The language analysis of the Czech narrative medical reports has been made. A new application for measuring diversity in medical reports written in any language is proposed. The application is based on the general concepts of diversities derived from f-diversity, relative f- diversity, self f-diversity and marginal f-diversity. The thesis has come to the conclusion that using a free text in medical reports is not consistent and not standardized. The standardized terminology would bring benefits to physicians, patients, administrators, software developers and payers and it would help healthcare providers as it could provide complete and easily accessible information that belongs to the process of...
|
|
Regulation of Cathepsin D Activity and Activation
Máša, Martin ; Mareš, Michael (advisor) ; Jonáková, Věra (referee) ; Holada, Karel (referee)
PhD Thesis ABSTRACT REGULATION OF CATHEPSIN D ACTIVITY AND ACTIVATION Martin Máša supervisor: Michael Mareš Department of Biochemistry Faculty of Science Charles University Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic PRAGUE 2009 Introduction Cathepsin D (CD) is an aspartic peptidase located in the lysosomes of all mammalian cells, its main role is catabolic degradation of proteins. More over CD is known to participate in a range of physiological processes such as apoptosis and tissue homeostasis, as well as in the regulation of angiogenesis and the production of peptidic antigens. The role of CD in pathophysiology is associated with several diseases such as Alzheimer's disease and cancer. Alzheimer's disease is a neurodegenerative disorder, which is generally considered to be the most common form of dementia. Progression of this disease is accompanied with the deposition of amyloid plaques (AP) in the brain, which leads to neurodegeneration. The AP is a fragment released from amyloid precursor protein (APP) cleaved by secretases1 . High levels of CD were found in cerebrospinal fluid of the Alzheimer's patients2 . It was demonstrated that CD is able to cleave APP and produce the pathogenic AP. A genetic polymorphism in the CD gene was reported, which changes...
|
|
The use of taping and kinesiotaping in physiotherapy
Ševečková, Tereza ; Polavková, Radka (advisor) ; Brožová, Kamila (referee)
This thesis is focused on the possibilities of using taping and kinesiotaping at physiotherapy. Application of the methods was provided in three different diagnoses. These were instability of the knee joint after plastic operation LCA, hallux valgus and backpain in the third trimester of pregnancy. The thesis is divided into the theoretical and practical part. The theoretical part describes the methods taping and kinesiotaping and it refers to the problems of the individual diagnoses. The practical part uses the qualitative research where three case reports are processed. The case reports contain introductory kinesiological analysis, progress of the therapy, checking kinesiological analysis and the therapy's evaluation. In the thesis taping and kinesiotaping are used individually despite the fact that these methods are just supplementary to the therapy. It is done in this way so as to be possible to evaluate the efficiency of these methods in selected diagnoses. Key words: taping, kinesiotaping, plastic operation LCA, knee joint after plastic operation LCA, hallux valgus, backpain, pregnancy
|
guest ::
