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Military Area as a Determinant of Microregion Population Development
Kusovská, Marie ; Šídlo, Luděk (advisor) ; Fialová, Ludmila (referee)
Military Area as a Determinant of Microregion Population Development Marie Kusovská Abstract The study deals with military area as a specific factor of microregion population development. The objective of the study is to describe and demonstrate the different effects of current and former military areas on neighbourhood population's demographic behaviour. The analysis is focused on the period of 1995-2010 and takes place in five current military areas: Boletice, Brdy, Březina, Hradiště and Libavá and three former military areas: Mladá (today's municipality Milovice), Ralsko and Dobrá Voda. The study examines the population development and its structure, natural and mechanical movement, including an analysis of migration directions. There is a finding that the municipality Milovice and Ralsko differs significantly from other areas in young age structure, high levels of total fertility rate and the intensity of immigration. At the level of mortality no significant differences were indicated. Therefore, it appears that a military area can be considered as a determinant of microregion population development, but it depends on the military uses of this area and in case of its cancelation it depends on the future civilian use.
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Evolutionary implications of innate immunity receptors polymorphism
Bainová, Zuzana ; Vinkler, Michal (advisor) ; Zajícová, Alena (referee)
Interactions between hosts and their parasites are considered to be one of the major forces driving animal evolution. It can be assumed that the evolutionary changes will occur especially in host molecules directly involved in these interactions. The first line of host defense is formed by innate immunity receptors among which also pattern recognition receptors (PRRs) belong. PRRs detect the presence of parasites at the beginning of their invasion by binding characteristic structures of their bodies (so called pathogen-associated molecular patterns, PAMPs, e. g. lipopolysaccharide, flagellin or peptidoglycans) or abnormal self molecules (damage-associated molecular patterns, DAMPs, e.g heat shock proteins). Although this mechanism of immune system activation is based on the recognition of ligands that are relatively evolutionarily conservative in pathogens, growing body of evidence suggests that PRRs are highly polymorphic on both interspecific and intraspecific level. High frequencies of minority alleles can be observed in most populations studied. It has been proven that particular alleles of many PRRs may associate with increased or decreased resistance to various infectious or autoimmunity diseases. Relationship between polymorphic receptor and a disease could be the main force, which shapes the...
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Actin and its regulation in clathrin endocytosis
Pešanová, Denisa ; Libusová, Lenka (advisor) ; Janštová, Vanda (referee)
4 Abstract Actin filaments and their dynamics play an important role in eukaryotic membrane remodelling. Actin regulatory proteins are required for actin dynamics control. During clathrin-mediated endocytosis actin and regulatory proteins interact with clathrin and adaptors proteins. Together they assist membrane invagination and scission of vesicles. Actin structures are fundamental for formation, internalization and movement of endocytic vesicles in yeast. In mammalian cells, actin is less involved especially in the early stage of endocytosis. Models reflecting different roles of actin in clathrin-mediated endocytosis in yeast and mammals are still lacking despite the latest imaging methods. The goal of this bachelor thesis is to offer a compact summary of controversial observations of actin regulation in endocytosis based on recent studies and simultaneously present selected mechanisms of interactions of the most important proteins, which influence actin dynamics in the clathrin-mediated endocytosis. Key words actin, clathrin-mediated endocytosis, Saccharomyces cerevisiae, regulatory proteins
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Valuation of Credit Derivatives
Davidová, Věra ; Witzany, Jiří (advisor) ; Myška, Petr (referee)
Credit derivatives are very interesting financial instrument both theoretically and practically. Their valuation has become an often discussed topic during the financial crisis since 2007. First part of this work is dedicated to standard types of credit derivatives, mainly to description of their character and to information about the historical development and also about the actual situation on the credit derivative market. However, this work is primarily focused on valuation of more complicated credit derivatives, namely Collateralized Debt Obligation (CDO), where modeling of correlation between underlying assets is required e.g. by copula functions. Then it deals with the mechanism of allocation of cash flow from underlying portfolio to CDO debt tranches, which is called financial waterfall. The goal of this work is to estimate price of a derivative by simulation methods and to examine an impact of changes in correlation structure inside portfolio, in recovery rates of assets and in other parameters of valuation. This valuation runs on real data about traded derivative, so it can be compared to its market value.
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Financial Analysis of CDO Structures
Dvořáková, Jitka ; Bartoš, Milan (referee) ; Myška, Petr (advisor)
This thesis deal with structured products which term is Collateralized Debt Obligations. Thesis describe mechanism, how this structures are working, pricing methods, which are using copula function and solve problems with choise of collateral pool, which substantially determine results of quantitative analysis of this products. Finally are these methods and results of quantitative analysis applied to the fictive collateral pool.
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Professional singer voice disorder prevention
Křemenáková, Pavla ; Hánová, Zina (advisor)
The human voice is most definitely a musical instrument at all. is given by every human being without distinction, but only some are blessed with more extreme musical talent. If they can also combine it with the correct techniqueand a morality can go to expensive professional singers. these people then for the exercise of their profession require maximum voice quality, which is voice function correctly determined without any organic or functional disorders. Each instrumentalist is familiar with the substance, mechanics and physical properties of his instrument and knowshow to maintain and nurse, so that he could rely on in the game. A similar principleapplies to professional singers. It is important to understand not only his instrument in terms of structure and physiology, but also know how to properly care for him. The situation is is more complex than the instrumental artist. Voice, especially the singing is the only one
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CUG Codon in Pathogenic Yeasts of the Genus Candida
Marečková, Lucie ; Půta, František (referee) ; Heidingsfeld, Olga (advisor)
2. Abstract In many Candida species the standard leucine CUG codon is translated as a serine, although not in 100% cases. This dual specifity of the CUG codon has evolved through a mechanism that required codon ambiguity mediated by a unique tRNACAG, which is in vitro aminoacylated more often by serine than by leucine. This codon ambiguity has been tolerated for more than 170 million years. The explanation at least for now is that the CUG codon reassignment could have generated genetic diversity that facilitated occurrence of new phenotypes resistant to stress. Beside this, an important step was to reduce negative impact of the codon ambiguity by crucial mutations in the structure of the ser-tRNACAG. Candida species became a valuable experimental model for elucidation of the genetic code changes. While consequences of the CUG codon reassignment have been extensively studied in Candida albicans, this topic has not yet been addressed in Candida parapsilosis. Solving the structure of C. parapsilosis secreted proteinase Sapp1p provided a tool to carry out a "case study" of possible effects of the CUG codon ambiguity. The SAPP1 gene contains one CUG codon, and the respective serine is located on the loop in the close proximity of the active site of the proteinase.
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Molecular simulations in structure analysis of intercalates
Veteška, Marek
The samples of hydrotalcite intercalated with pyrenetetrasulphonate acid were obtained. Their structure cannot be precisely determined by the analysis of X-ray data. The amount of water in the interlayer space and the structure of the samples differed considerably in dependence on humidity. Convenient procedures and minimization strategy were established on the base of X-ray data in the molecular mechanic and the molecular dynamic simulations. A procedure for using of the supramol software was made. This software enables deterministic searching of conformational space. Initial models from supramol were minimized in the Cerius2 software using the Universal force field and then they were eventually optimized by the molecular dynamics. The arrangement of molecules of pyrenetetrasulphonate acid and water was determined in the interlayer space of hydrotalcite for three different samples with different interlayer distances: The sample 1 prepared by RH = 0%: 9.83A; the sample 2 prepared by RH = 84%: 13.63A; the sample 3 prepared RH = 40%-50%: 11.74A a 12.81A. The results of these structures proved a large variability of the arrangement of the molecules in the interlayer space. The sample No. 3 seems to be unstable.
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International system of football: international migration of Czech football players and the role of players' agents
Musil, Petr ; Novotný, Josef (advisor) ; Flemr, Libor (referee)
The aim of the thesis is to bring more insight into the international organization of football. The scope of the analysis is the institutional framework of football and migration of professional football players. And in particular functioning and struggle between and within the world's football governing body FIFA and the EU. More stress is devoted to the process of migration of players at the global as well as European levels, and the structural development of the migration of the Czech players abroad. The former is analyzed for the last few years, while the latter between the seasons of 1993/94 and 2007/08. The focus is also given to the study of mechanism of international migration, which tries to reveal the role of the FIFA player's agents in the international transfers of the Czech players. The results of this work are based on data obtained from the internet databases containing information about foreign engagement of players and on a number of interviews with the Czech FIFA players' agents and their assistants. These were organized by the author during his original research. The analysis shows that the football's labour markets are more of regional than global character and are determined by the geographic, cultural and historical conditions. Moreover the analysis depicts that for the structure of...
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Molecular simulations in structure analysis of intercalates
Veteška, Marek ; Pospíšil, Miroslav (advisor) ; Beneš, Ludvík (referee)
The samples of hydrotalcite intercalated with pyrenetetrasulphonate acid were obtained. Their structure cannot be precisely determined by the analysis of X-ray data. The amount of water in the interlayer space and the structure of the samples differed considerably in dependence on humidity. Convenient procedures and minimization strategy were established on the base of X-ray data in the molecular mechanic and the molecular dynamic simulations. A procedure for using of the supramol software was made. This software enables deterministic searching of conformational space. Initial models from supramol were minimized in the Cerius2 software using the Universal force field and then they were eventually optimized by the molecular dynamics. The arrangement of molecules of pyrenetetrasulphonate acid and water was determined in the interlayer space of hydrotalcite for three different samples with different interlayer distances: The sample 1 prepared by RH = 0%: 9.83A; the sample 2 prepared by RH = 84%: 13.63A; the sample 3 prepared RH = 40%-50%: 11.74A a 12.81A. The results of these structures proved a large variability of the arrangement of the molecules in the interlayer space. The sample No. 3 seems to be unstable.
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