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Determination of the compressibility of excipients used for formulation of tablets with theophylline.
Kousoulidou, Viktoria ; Šklubalová, Zdeňka (advisor) ; Ondrejček, Pavel (referee)
1 Abstract Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Assoc. Prof. PharmDr. Zdenka Sklubalova, Ph.D. Student: Viktoria Kousoulidou Title of Thesis: Determination of the compressibility of excipients used for formulation of tablets with theophylline The current thesis is focused on the compressibility properties of five powders used in tablet formulation: Comprecel, Spherolac, DI-CAFOS D160, DI-CAFOS A150 as excipients and Theophylline as the active substance. The particle size, moisture content, bulk density and flowability of the powders are determined. The powders are compressed and the results are evaluated by means of the parameters of the compaction equation and the force-displacement method (compression under 5, 10, 15 kN). Then, the crushing strength of tablets prepared from each powder by the force-displacement method is measured. The average values of the crushing strength are used to calculate the tensile strength of the tablets. Best compressibility is found in Comprecel and Theophylline with tensile strength values of 1.31 MPa under 5 kN, 3.31 MPa under 10 kN, 4.75 MPa under 15 kN and 1.02 MPa under 5 kN, 2.27 MPa under 10 kN, 3.09 MPa under 15 kN, respectively.
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Evaluation of compressibility of tableting mixtures containing theophylline using a compaction equation
Matyášová, Andrea ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Andrea Matyášová Title of Thesis: Evaluation of compressibility of tableting mixtures containing theophylline using a compaction equation This thesis is aimed at the evaluation and comparison of excipients used in production of tablets. The compaction process of these excipients was evaluated using the parameters of the compaction equation. The mixtures of four fillers in various ratios were evaluated. These mixtures contained also theophylline as model drug and magnesium stearate as lubricant. The used three-exponential equation was previously developed by doc. RNDr. Milan Řehula, CSc. By using this compaction equation the volume reductions, speeds of volume reductions and consumed energies were calculated and evaluated. The results of this work showed that particular used fillers have different effect on the compaction process flow. That is caused primarily by different behavior of these materials during compaction and by formation of different types of bonds. Also the need of thorough cleaning and drying of compaction aid before compaction was confirmed.
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Evaluation of tensile strength of tablets containing theophylline
Janoutová, Hana ; Šklubalová, Zdeňka (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Hana Janoutová Title of Thesis: Evaluation of tensile strength of tablets containing theophylline The aim of this thesis was to determine tensile strength of tablets containing theophylline. Tensile strength was studied as a function of the composition of mixtures of the used fillers and especially on their ratio. In the theoretical part, the used materials - lactose SpheroLac 100, microcrystalline cellulose Comprecel 102, dibasic calcium phosphate dihydrate Di-Cafos D160, anhydrous dibasic calcium phosphate Di-Cafos A150, theophylline and magnesium stearate are described. This work also evaluates force-displacement record, tensile strength and various factors that affect tensile strength. Parameters of force-displacement record and tensile strength of the tablets compressed with compresssion force 10 kN were evaluated in the experimental part. The measured results show that higher values of precompression energy (E1) and energy of plastic deformation (E2) were detected in mixtures A, C and E which contain Comprecel 102, and the lowest values were detected in mixtures B which contain Sphero-Lac 100 and Di-Cafos D160. Values of energy...
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Evaluation of disintegration time of tablets containing theophylline
Brtnová, Soňa ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Thesis supervisor: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Mgr. Pavel Ondrejček Student: Soňa Brtnová Title of Thesis: Evaluation of disintegration time of tablets containing theophylline The influence of used fillers on energetic profile of compression, especially influence on disintegration time of tablets with theophylline as a model drug, was studied in this thesis. Four tablet fillers were studied - microcrystalline cellulose Comprecel 102, lactose SpheroLac 100, calcium hydrogen phosphate anhydrous Di- Cafos A150 and calcium hydrogen phosphate dihydrate Di-Cafos D160. Tablets contained different proportion of two fillers, theophylline as a model drug and lubricant magnesium stearate. Tablets were compressed by the same compaction force 10 kN. The force- displacement record was evaluated using the particular energies of compaction process. Parameters of compaction process were influenced mostly by Comprecel 102. According to results there is no possibility to replace Di-Cafos D160 with Di-Cafos A150 in the mixtures. It was also found that SpheroLac 100 and Di-Cafos D160 shows similar behavior. Time of disintegration of tablets is mostly dependent on the used fillers. Tablets...
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Development of special protective materials for hygienically clean areas
Seják, František ; Vyhnánková, Michaela (referee) ; Drochytka, Rostislav (advisor)
The diploma thesis deals with the development of special protective materials for hygienically clean plants. The main aim of the thesis is to develop a special protective material on a polymer base usable for hygienically clean industrial plants in two quality levels (economy and premium). The first of the developed polymer protective materials is physiologically harmless (economy) – suitable for contact with eatables. Second, premium material is antibacterial, especially suitable as a floor coating in hospitals, kitchens, sanitary facilities, schools and kindergarten etc. A partial aim is the replacement currently used primary raw materials as fillers by suitable secondary raw material.
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Fillers in Czech Vocabulary
PILOUŠKOVÁ, Darina
This paper deals with defining and mapping of fillers in the Czech vocabulary. It also analyzes its problematic function in Czech language system. The analysis is divided into two parts- methodology and research. The first part is dedicated to fillers' purpose in the Czech vocabulary and classification of fillers into word classes. It also deals with other linguistic publications on this topic. The research is aiming to analyze certain authentic speeches and to specify the position of fillers in the communication of Czech speakers.
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Lift unit for paste container
Mimochodek, Martin ; Svoboda, Pavel (referee) ; Dvořáček, Jiří (advisor)
The first part deals with the sorts and a separation of the fillers which are used in the food-processing industry. The second part more deeply describes various construction variants of the lift unit rotary piston filler, especially their properties, sort of the driving mechanism and an used components. Final system design is created in Autodesk Inventor 10.
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Mechanical and Chemical Surface Endurance of polymers materials, testing and posibilities fro improvements
Vaníček, Štěpán ; Seidlová, Michaela (referee) ; Petránek, Vít (advisor)
Mechanical and chemical resistant multilayer polymeric floors are the most important characteristics of classification in the evaluation of surface and texture. Mentioned as organic binders which are used for the realization of the matrix. Further discussion on how to get fillers forming the supporting folder. Created a summary of the key test of mechanical and chemical characteristics according to current standards. The theoretical part is concluded with a reflection on the possibilities of improving the surface resistance of synthetic floors. The practical part was focused on testing the strength, resistance to impact and adhesion to the base layer. Finally, the overall evaluation of the test results in accordance with the theoretical part.
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