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Spatial patterns of links between temperature extremes and cardiovascular mortality in the Czech Republic
Urban, Aleš ; Kyselý, Jan (advisor) ; Huth, Radan (referee) ; Dobrovolný, Petr (referee)
Name of the thesis: Spatial patterns of links between temperature extremes and cardiovascular mortality in the Czech Republic Author: Mgr. Aleš Urban Previous studies have examined relationships of high and low air temperatures to mortality due to cardiovascular diseases (CVDs) in the Czech Republic as a whole. Much less has been understood about possible regional differences in the heat and cold effects on mortality. Within four papers published in international peer-reviewed journals, the author of this thesis investigated links between extreme temperatures and CVD mortality in the Czech Republic while considering in particular differences between (i) urban and rural areas, (ii) regions with different socioeconomic status, and (iii) regions with different physical-environmental conditions. Various biometeorological approaches were compared in order to identify meteorological characteristics affecting heat- and cold-related mortality. Excess mortality was determined as differences between observed and expected daily values, the latter being adjusted for long-term changes, annual and weekly cycles, and epidemics of influenza/acute respiratory infections. Air temperature, biometeorological indices (including the Universal Thermal Climate Index, Apparent Temperature, and Physiologically Equivalent...
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Role of the FTO gene in the genetic determination of common multifactorial diseases
Dlouhá, Dana
Obesity is a risk factor for development of cardiovascular disease, diabetes type 2 and some cancers. Newly detected genetic risk factor for body weight is the FTO gene ("fat mass and obesity associated"). The aim of this thesis was determine 1) whether the presence of risk alleles correlate with BMI in Czech population and to determine 2) whether there is an association between variants in the FTO gene and risk of myocardial infarction/ acute coronary syndrome (MI/ ACS), 3) renal failure (ESRD), or 4) incidence of colorectal cancer (CRC). We analyzed polymorphisms rs17817449 (first intron) and rs17818902 (3rd intron) using by PCR-RFLP and then also RT PCR. We found an association of the first intron variant (but not the 3rd one) and BMI in Czech control population. We have detected an association of 1st intron SNP and BMI changes during the intervention study in obese children, but not in obese females. We found a correlation between the risk allele and increased risk of ACS (OR 1.49) in patients with MI. In patients with ESRD was detected association between the risk allele and the risk of disease (OR 1.37). We didn't confirmed the association between rs17817449 and the development of CRC. Representative selected groups of the Czech populations "MONICA" and "HAPPIE" were used as controls. One...
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Role of perivascular fat tissue in the development of cardiovascular diseases
Čejková, Soňa ; Ždychová, Jana (advisor) ; Pavlišová, Jana (referee)
Abnormal vascular smooth muscle cell (VSMC) proliferation is thought to play an important role in the pathogenesis of atherosclerosis. Adipocytes produce several paracrine bioactive substances that can affect VSMC growth and migration. Our study focused on the ability of epicardial adipocytes to produce bioactive substances together with studying of direct effect of these substances on the VSMC proliferation rate. The gene expression of human cytokines (IL-6, IL-8, IL-18, RANTES and MCP-1) and adipokines (leptin and adiponectin) was measured in primary cell lines of epicardial and visceral adipocytes, both in undifferentiated and mature statuses. Moreover, adipokine production (IL-6, IL-8, MCP-1, VEGF and adiponectin) in conditioned media obtained from above mentioned primary cell cultures of adipocytes was measured by a Luminex assay. The VSMC proliferation rate was measured after co-culturing with CM obtained from primary cell cultures of adipocytes. The epicardial preadipocytes showed an increased expression of IL-8 (3,25-fold, p<0,05) compared with visceral preadipocytes. The expression of the adiponectin in epicardial preadipocytes was markedly decreased in comparison of the expression in visceral preadipocytes (p< 0,0001). Moreover, the gene expression was dependent on the differentiation...
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Oxidative and carbonyl stress,microinflammation and cardiovascular risk in patiens with chronic kidney disease
Peiskerová, Martina ; Kalousová, Marta (advisor) ; Teplan, Vladimír (referee) ; Racek, Jaroslav (referee)
Short summary: Background: High cardiovascular risk in patients with chronic kidney disease is partly due to mineral dysbalance, microinflammation and oxidative stress. CKD patients accumulate traditional and non-traditional CV risk factors. FGF23, MMPs and PlGF belong among these non-traditional biomarkers of CV risk. FGF23 is a phosphaturic hormone and inhibitor of calcitriol synthesis. It is associated with vascular calcifications. Matrix-metalloproteinases (e.g. MMP-2, MMP-9) are proteolytic, proinflammatory enzymes, contributing to myocardial remodelation. Placental growth factor (PlGF) is a proangiogenic cytokine that is associated with LV hypertrophy in animal model. Plasmatic FGF23, MMPs and PlGF are elevated in CKD. Aim: We aimed to describe dynamic changes between several novel biomarkers of CV risk (FGF23, MMP-2, MMP-9 and PlGF) in CKD stages 1-5, to describe their mutual correlations and possible association with traditional CV risk markers. We studied possible association of laboratory and echocardiographic parameters in patients with CKD stages 2-4. Methods: In a cross-sectional study we evaluated 80 patiens with CKD 1-5 and 44 healthy controls. In a prospective study we evaluated echocardiographic and laboratory parameters in 62 patients with CKD 2-4 for an average study period of 36±10...
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Cardiovascular disease and smoking. Treatment of tobacco dependence and cardiovascular risk
Zvolská, Kamila ; Králíková, Eva (advisor) ; Šteflová, Alena (referee) ; Tuček, Milan (referee)
(EN) Introduction: Tobacco dependence is one of the four major risk factors (RF), cardiovascular (CV) disease (CVD). Objective: Analysis of CV risk of patients of our Center for Tobacco-Dependent. Methods: A retrospective assessment of the presence of CVD, RF for CVD and CV risk level according to the method SCORE in our patients - smokers from 2007 - 2009 (N = 1,349, 52.2% males, age range 25-64 years, mean age 44 ± 11, 7). CV risk was also evaluated one year after the baseline visit including newly diagnosed CVD RF, abstinence from smoking was validated by carbon monoxide in expired air. The results were compared to those of smokers in the study postMONICA (N = 1,122, 54.5% men, mean age 46 ± 11). Compared to the general population of smokers (postMONICA) significantly more Center patients had automatically high CV risk and CVD. The prevalence of type 2 diabetes was comparable as well as prevalence of hypertension and dyslipidemia in smokers without automatically high CV risk. Significantly fewer Center patients without automatically high CV risk were obese, family history was also significantly lower risk. Significantly more women with low RF and significantly fewer men aged 55-59 and women aged 55-64 with SCORE ≥ 5% came to the Center. Success rate of Center patients with SCORE < 5 % was 44.3 %...
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Role of the FTO gene in the genetic determination of common multifactorial diseases
Dlouhá, Dana ; Hubáček, Jaroslav (advisor) ; Černá, Marie (referee) ; Rossmeislová, Lenka (referee)
Obesity is a risk factor for development of cardiovascular disease, diabetes type 2 and some cancers. Newly detected genetic risk factor for body weight is the FTO gene ("fat mass and obesity associated"). The aim of this thesis was determine 1) whether the presence of risk alleles correlate with BMI in Czech population and to determine 2) whether there is an association between variants in the FTO gene and risk of myocardial infarction/ acute coronary syndrome (MI/ ACS), 3) renal failure (ESRD), or 4) incidence of colorectal cancer (CRC). We analyzed polymorphisms rs17817449 (first intron) and rs17818902 (3rd intron) using by PCR-RFLP and then also RT PCR. We found an association of the first intron variant (but not the 3rd one) and BMI in Czech control population. We have detected an association of 1st intron SNP and BMI changes during the intervention study in obese children, but not in obese females. We found a correlation between the risk allele and increased risk of ACS (OR 1.49) in patients with MI. In patients with ESRD was detected association between the risk allele and the risk of disease (OR 1.37). We didn't confirmed the association between rs17817449 and the development of CRC. Representative selected groups of the Czech populations "MONICA" and "HAPPIE" were used as controls. One...
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Importance of primary and secondary prevention in cardivascular disorder
Koníčková, Veronika ; Bunc, Václav (advisor) ; Skalská, Marie (referee)
1 Abstract: Title: The importance of primary and secondary prevention of cardiovascular disease Goals: Develop a theoretical basis for the selected topic. Describe the basic principles of primary and secondary prevention, and thus prepare the groundwork for creating questionnaires. Questionnaire compiled to complement the information obtained from the literature on insight into the practice. Confirm or refute the hypotheses chosen on the basis of a questionnaire. Discuss the most frequently occurring phenomena and compare them with the latest reported information. Draw conclusions and recommendations. Method: For the theoretical treatment of the retrieval method was used. I compared the information and inclined to the best proven. The theoretical part resulted in the goals and tasks of work. For the practical part was conducted by questionnaire survey, which has additional information on the issue of primary and secondary prevention. In the end I obtained data compared with information obtained from studying literature. Results: Lack of information on primary and secondary prevention is mainly for young people aged 10-15 years. This trend is accompanied by the deteriorating health situation and the occasional occurrence of the "diseases of civilization", which can produce complications in adulthood....
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Selected differences in pathophysiology of cardiovascular system in women
Yang, Shiann-Guey ; Kittnar, Otomar (advisor) ; Ošťádal, Petr (referee) ; Danzig, Vilém (referee)
(summary of doctoral dissertation) It has become increasingly apparent in recent years that there are important differences of many cardiovascular disorders including ventricular tachycardias in men and women. Gender differences have been observed in the epidemiology, pathogenesis and clinical presentation of various ventricular arrhythmias. Physiological menopause occurs as a part of a woman's normal aging process being based on the natural cessation of estradiol and progesterone production by the ovaries. The dramatic fall in circulating estrogens levels at menopause impacts many tissues including cardiovascular system. Because the incidence of coronary heart disease (CHD) rises significantly after menopause, it has been hypothesized that women's CHD advantage before menopause (in comparison to men of the same age) could be due to the protective effects of estrogens. However, controversial results have been reported since early nineties until today. While some studies found reduction in the incidence of CHD and in mortality from cardiovascular diseases some other studies failed to provide any evidence for an independent role of estradiol levels in determining CHD in postmenopausal women and some studies even found positive association of endogenous estradiol with the risk of CHD among women above...
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A nurse task in the stress test in a cardiology
FIŠEROVÁ, Andrea
The theme of this work is the role of nurses in the cardiology stress tests. The first part of this work is theoretical and the other is practical. We determine the role of nurses in the cardiology stress tests. We focused on how to nurse in the cardiology department in the ward and the nurse directly at the stress tests. We also wanted to map different types of stress tests and activity nurses. The research we selected nurses working in ergometry, spiroegometrie, stress echocardiography and positron emission scintigraphy of the myocardium. Research for this work were 3 research questions.
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