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	The role of monocytes in pathogenesis of diabetes - immunogenetic study Paukner, Karel ; Daňková, Pavlína (advisor) ; Černá, Marie (referee) Type one diabetes is an autoimmune disease. It is caused by the destruction of β cells of Langerhans' pancreatic islets. Hyperglycemia is a major symptom of β cell destruction. Monocytes play a key role during T cell activation. T cell effect can be protective (Treg) or destructive. Monocyte destroys β cells as a macrophage and generates self-tolerance as a dendritic cell. The number of patients with T1D is increasing. In the presented work I aim to summarize current information about pathogenesis of T1D and I try to propose future way of research. Detailed record
	Molekulárna charakterizácia vybraných obranných faktorov v čeľadi Lumbricidae Mančíková, Veronika ; Bilej, Martin (advisor) ; Král, Jiří (referee) Earthworms belonging to oligochaete annelids have been a model for comparative immunology for over 40 years. They possess various defense mechanisms efficiently recognizing and responding to non-self substances. Among these there are molecules with many biological activities including cytolytic, antimicrobial and proteolytic. This work is aimed to compare the immunological features of two closely related earthworm species Eisenia andrei and Eisenia fetida. Due to many morphological and life cycle similarities they have been, until recently, regarded as members of subspecies. Interestingly, their natural habitat varies considerably, and it was of particular interest to investigate how these environmental differences affect the features of innate immunity of both species. Key words: annelids, innate immunity, Eisenia andrei, Eisenia fetida, CCF, fetidin, lysenin, lysozyme Detailed record
	Searching for Toll-like receptors agonists that would interact synergistically with ligands of phagocytic receptors and that could be used in cancer immunotherapy in human medicine LENZOVÁ, Zuzana The goal of this thesis was to find agonists of Toll-like recptors that would interact with ligands of phagocytic receptors synergistically, would cause a strong suppresion of tumour growth, and could be safely used in human medicine. Detailed record
	Cancer immunotherapy based on the use of microorganisms and their parts. Role of neutrophil extracellular traps formation TOMŠOVÁ, Julie In the first part of the theses, I studied therapeutical effect of intratumoral application of various types of bacteria on melanoma B16-F10 bearing mice alone or in combination with another immunostimulatory compounds. Tumour size, metastasis and survival were monitored. The second part was focused on study of cytotoxic effect of neutrophils on melanoma cells and the role of neutrophil extracellular traps formation. Detailed record
	Study of clinically applicable cancer immunotherapy and their mechanisms GLASEROVÁ, Simona The aim of this thesis was study of replacement of LPS in innate immunity based cancer immunotherapy. Application of poly (I:C) with mixture of mannan-SMCC + R-848.HCl leads to synergy, higher reduction of tumor growth and significant prolongation of survival. The significance and mechanism of action of neutrophils have also been studied within this therapy. Detailed record
	Mechanisms of the immune response during the cancer treatment with ligands of phagocytic receptors anchored to the surface of malignant cells AUEROVÁ, Marie The aim of this thesis was to obtain some insights into mechanisms by which the immune system affects melanoma cells after anchoring agonists of phagocytic receptors (laminarin and f-MLF) to their surface. To verify the hypothesis that innate immune system plays a critical role, in vivo experiments were performed on SCID mice. To elucidate the importance of CR3, CD11b-deficient mice were used. In in vitro experiments production of inflammatory cytokines in tumor tissue was examined as well as the release of myeloperoxidase from neutrophil granules after incubation with malignant cells. Detailed record
	Cancer therapy based on the use of the anchored agonists of phagocytic receptors. The study of mechanisms using immunodeficient mice WALDMANNOVÁ, Eva The aim of this thesis was to study the mechanisms of innate imunity involved in the degradation of tumor cells on which the ligands of phagocytic receptors were installed. For this purpose both in vivo experiments using immunodeficient mice, and in vitro experiments based on monitoring the levels of inflammatory cytokines produced in the tumor tissue and on measuring the level of myeloperoxidase released during neutrophil degranulation were performed. Detailed record
	Study of cancer therapy based on the use of Zymosan A WALDMANNOVÁ, Eva The aim of this thesis was to study the efficacy of Zymosan A derived from Saccharomyces cerevisiae in anticancer therapy. For this purpose we tried to increase its anticancer influence by combining it with some other immunomodulators. Detailed record
	Anchoring of agonists of PRRs on tumor cells with the aim to cause antitumor immune reaction based on the innate immunity WACHTLOVÁ, Markéta Transduction of melanoma cells with the aim to induce avidine expression on tumor cell surface was studied. Subsequently the method enabling quantification of binding of ligands to the cell surface was developed. Detailed record
	Peptides with an antimicrobial activity isolated from the larvae of the fleshfly Neobellieria bullata Neubauerová, Tereza ; Macková, M. ; Macek, Tomáš ; Šanda, Miloslav ; Voburka, Zdeněk Short cationic peptides play an important role in the innate immunity of all living organisms. Some of the 700 peptides described so far have become a potential source of new antibiotics to combat the increasing emergence of drug-resistant bacteria. Haemolymph of larvae of the fleshfly were chosen as a source of such peptides. Detailed record

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