Original title: Mechanismy imunitní odpovědi při léčbě rakoviny kotvením ligandů fagocytárních receptorů na povrch nádorových buněk
Translated title: Mechanisms of the immune response during the cancer treatment with ligands of phagocytic receptors anchored to the surface of malignant cells
Authors: AUEROVÁ, Marie
Document type: Master’s theses
Year: 2014
Language: cze
Abstract: The aim of this thesis was to obtain some insights into mechanisms by which the immune system affects melanoma cells after anchoring agonists of phagocytic receptors (laminarin and f-MLF) to their surface. To verify the hypothesis that innate immune system plays a critical role, in vivo experiments were performed on SCID mice. To elucidate the importance of CR3, CD11b-deficient mice were used. In in vitro experiments production of inflammatory cytokines in tumor tissue was examined as well as the release of myeloperoxidase from neutrophil granules after incubation with malignant cells.
Keywords: cancer therapy; immunodeficiency; innate immunity; melanoma B16-F10; PAMPs
Citation: AUEROVÁ, Marie. Mechanismy imunitní odpovědi při léčbě rakoviny kotvením ligandů fagocytárních receptorů na povrch nádorových buněk. České Budějovice, 2014. diplomová práce (Mgr.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/32530

Permalink: http://www.nusl.cz/ntk/nusl-180584


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Master’s theses