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Synthesis of novel cardioprotective iron chelators
Hrušková, Kateřina ; Roh, Jaroslav (referee) ; Vávrová, Kateřina (advisor)
Oxidative stress participates in patophysiology of many serious cardiovascular diseases. Free intracellular iron occurs as a catalyst of Haber-Weiss and Fenton reaction between superoxides and peroxides increasing the formation of highly toxic hydroxyl radicals, which cause cell damage. Iron chelators diminish the pool of free iron and thus become perspective agents in therapy of various diseases, e.g. anthracycline-induced cardiotoxicity. Aroylhydrazones group, such as salicylaldehyde-isonicotinoylhydrazone (SIH), appear to be highly efficient chelators. Unfortunately, pharmacokinetic studies focused on these compounds revealed their low stability in plasma. Therefore, I synthesised a series of SIH analogs in order to increase their stability together with preserving the ability to chelate free intracellular iron and to define their structure-activity relationships. A basic hypothesis in design of the novel chelators was using substituted ketone instead of aldehyde, leading potentially to an enhanced stability of hydrazone bond. SIH Two different methods were used during the reactions, a conventional heating in an oil bath and heating in a microwave reactor. The latter caused a significant shortening of the reaction time. In vitro studies of novel compounds showed their higher stability in plasma,...
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A Contribution to the Study of Early English Settlement in North America
Přívozník, František ; Kovář, Martin (advisor) ; Valkoun, Jaroslav (referee)
The Bachelor thesis describes the beginnings of English settlement in North America during the 17th century. The thesis deals with the development of the Roanoke Colony and the causes of its failure, then focuses on the economic and commercial importance of Virginia and the religious issues in this area. The thesis attempts to clarify the motives of England for founding the colonies in the broader foreign policy view, together with many aspects e.g. the social structure of settlers, local governments or relations with the natives. Keywords English Settlement, North America
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Private Equity and Venture Capital Investment
Cupák, Patrik ; Sato, Alexej (advisor) ; Černohlávková, Eva (referee) ; Baláž, Peter (referee) ; Kursová, Petra (referee)
This doctoral thesis is focused on the most progressive part of alternative financing for small business nowadays, on Private Equity and Venture Capital. Despite its undeniable importance, compared to the more traditional ways of collecting financial resources for further business development, only very little research has been done in this area from the point of view of economics sciences. The recent world financial crisis has only served to highlight the importance of Private Equity. However, the theory is still unable to provide answers to many questions raised by practice. In view of that, the main aim of the thesis is to provide detailed description of the field, examine the current trends in Private Equity investment and introduce Private Equity as one of the most perspective systems of business activity financing. The thesis is divided into three main parts. The definition of financial market, its functioning as well as the main agents are included in the first part of the dissertation. The second part deals with the comparison between the EU and its new member states represented by the region of Central and Eastern Europe, and also examines the factors that have been influencing Private Equity development in the last four years and their mutual interdependencies. In the third part, the original valuation model measuring total returns of Private Equity investments is developed. In his dissertation, the author tests the following hypotheses: 1. Private Equity can be considered as one of the most risky investments among all. Total return from PE is well above the average of any other forms of investment. 2. The total amount of Private Equity investments in CEE region is growing steadily. The largest part of this investment is constituted by Buy-outs. Both tested hypotheses are confirmed. This doctoral thesis of Patrik Cupak provides a detailed analysis of Private Equity investments development. The main contribution of the dissertation is the fact that it represents the first analysis comparing the actual situation in Private Equity investments in European and CEE region of this type. The thesis also has significant theoretical and practical contributions due to its wide content and original analysis in this field. Its findings can be thus used in both, practice as well as the academic field.
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Developement of the Russian foreign trade in the period after disintegration of the Soviet Union until the present time
Osipova, Anna ; Havel, Jiří (referee) ; Půlpán, Karel (advisor)
The thesis describes development of the foreign trade of the Russian Federation in the period after disintegration of the Soviet Union until the present time. It is concentrated particularly on the balance of trade, export and import of the RF. The objective of this thesis is the analysis of main factors that have been influencing components of Russian foreign trade and observation of their impact on the Russian foreign trade activity. Within this framework I follow the trade development of particular items of Russian production and pay attention to the main commodities such as energy resources, machinery and equipment. The thesis also analyses trade relationships between RF and other countries and coalitions. Part of the thesis outlines possible future of the Russian FT during the period 2000-2015 and defines alternatives of the Russian foreign trade activity in dependence on oil prices, since oil is one of the most important components of the Russian export.
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Contemporary Development of the Persian Gulf States
Cimpová, Jitka ; Novotná, Yvona (advisor) ; Volenec, Otakar (referee)
This thesis analyses Persian Gulf states foreign policies development and a position of the region in international relations using a collective case study. At the theoretical level the thesis works on the elements of (neo) realism, (neo) liberalism and social constructivism. The analysis is focused on security context and examines both challenges to internal security (regime and government, Shia expansion, the so called Arab spring, media) and external security (the Israeli-Palestinian conflict, Syrian conflict, terrorism, globalization and oil market developments). In the regional security complex of the Gulf are involved interests of the three main world powers, U.S.A., Russia and China. Regional cooperation in the GCC organization and mutual relations of the Gulf States are important, too. Based on the findings it is possible to assert that the development of the region is dynamic and depends on the oil rents.
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Oil as a factor in international relations of Middle East
Herbstová, Michaela ; Novotná, Yvona (advisor) ; Matějka, Zdeněk (referee)
This diploma thesis works with the hypothesis that the existence of oil, which is a non-renewable resource of energy with limited availability (geographically as well as in terms of the available amount)influenced internal formation and international relations of the Middle Eastern states, which are the primary world oil exporters. The main goal of this thesis is to analyse this assumption based on the history of oil industry and determine to what extent has the oil contributed to the current position of the Middle East in the international relations.
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Analýza obchodních vztahů mezi Evropskou unií a Latinskou Amerikou
Daza Aramayo, Lourdes Gabriela ; Krebs, Vojtěch (advisor) ; Macháček, Jaroslav (referee) ; Benáček, Vladimír (referee)
The Doctoral Thesis "Analysis of Trade Relations between the European Union and Latin America from 1995-2011" focuses on the determination Latin America's potential as a trading partner for the European Union. It will be based on an analysis of the region's trade relationships between 1995 and 2011 through different econometric models and a macroeconomic analysis. It will make recommendations for improving economic relation policies with Latin America and the European Union as well as identify the sectors which could represent great potential for trade between both regions. The research is divided into seven chapters: The first chapter covers international trade theory; this part comprises the theoretical aspects directly related to international trade. The second chapter analyzes the macroeconomic features of Latin American countries and compares them with data from the European Union. A separate, detailed analysis of 17 Latin American countries was performed and the potential of each one to make their importance known to the world and define their geopolitical position is described. The third chapter details the trade policies of the European Union and Latin America. The fourth chapter discusses trade relations between Latin America and the European Union through a look at the trade agreements that have been signed between the European Union and Latin American countries and tries to identify possible causes of failures for agreements not signed. This chapter also studies the sectorial composition of trade between the two regions, emphasizing the asymmetry between these trades flows as they enter the countries studied. The fifth chapter, the heart of this research paper, analyzes the trade relations between the EU and Latin America through a gravity model, identifying the obstacles and barriers to international trade between the two regions. The second part of this chapter discusses institutional factors, which, as a result of the conclusions from the gravity model explained earlier in the chapter, play an important role in international trade between Latin America and the European Union. This section contains a comparative analysis of the situation of the institutional factors in the 29 Latin American countries which were analyzed in the gravity model. This chapter also includes a trade simulation between the Czech Republic and Latin America with the institutional factors in Latin America showing a 10% improvement. In the sixth chapter, the competitiveness of 17 Latin American countries is calculated using the results of the barriers to international trade through a new method based on the comparison of indicators, ranked by dimension and according to the weight thereof for a period of time. The last chapter focuses on the identification of the variables determining foreign direct investment in Latin America, represented by 29 countries and over a period of time from 1995 to 2011. It considers variables traditionally not considered such as the number of patents registered, the tax rate and institutional factors, which have revealed important explanatory variables as well as those traditionally considered such as GDP, inflation, population, the share of GDP by sector, income level, etc. The last part of this research lists the conclusions reached and proposes recommendations for economic relations policy development between Latin America and the European Union.
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Sub-Saharan oil sector: significancy and foreign investment
Čítek, Rostislav ; Hnát, Pavel (advisor) ; Machytka, Daniel (referee)
The thesis focuses on definition of importance of oil resources in sub-Saharan Africa for international trade. The aim of this thesis is to define the most remarkable Sub-Saharian oil sector producers and their relations with transnational oil corporations as the main FDI sources. Emphasis is placed on relationships with Chinese national oil companies and the consequences of these relations.
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Potential of the European Neighbourhood Policy for EU energy security
Fráně, Luděk ; Dubský, Zbyněk (advisor) ; Sršeň, Radim (referee)
Relations between the EU and its neighbour countries and regions are very important for either side. One of the topics which joins them is the energy resource issue. Daily, millions of barrels of oil and billions of cubic meter of natural gas flow through this area into Europe. This diploma thesis deals exactly with this matter, e.i. European Union's energy security. It is a very topical, discussed but above all for the EU important theme. The purpose of this thesis is to connect the conception of EU's energy security through the European Neighbourhood Policy, e.i. the policy which the EU has established to create stability and prosperity with the neighbour regions of North Africa, Near East, Eastern Europe and the Caucasus states. The outcome of this paper should be to evaluate the potential of the countries in the European neighbourhood and the potential of the neighbourhood policy for strengthening the EU security policy, that means to summarize the possibilities for effective co-operation in the field of energy and to say if this co-operation could strengthen European Union's energy security.
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